MIA_03989_1

Protein

Length

447 amino acids

Protein function

EGGNOG:	0PFCF	CEM1	3-oxoacyl- acyl-carrier-protein -synthase
SGD closest match:	S000000863	CEM1	3-oxoacyl-[acyl-carrier-protein] synthase homolog
CGD closest match:	CAL0000200784	CEM1	3-oxoacyl-[acyl-carrier-protein] synthase

Protein alignments

	%id	Aln length	E-value
MCA_02171_1	71.158%	423	0.0	MCA_02171_1
A0A0J9XK02_GEOCN	65.882%	425	0.0	3-oxoacyl-[acyl-carrier-protein] synthase OS=Geotrichum candidum GN=BN980_GECA24s00934g PE=3 SV=1
A0A167FEZ7_9ASCO	56.982%	444	2.20e-168	3-oxoacyl-[acyl-carrier-protein] synthase OS=Sugiyamaella lignohabitans GN=CEM1 PE=3 SV=1
A0A1E3PSZ5_9ASCO	56.808%	426	1.20e-167	3-oxoacyl-[acyl-carrier-protein] synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48595 PE=3 SV=1
UniRef50_Q4WHD8	53.699%	419	4.33e-160	3-oxoacyl-[acyl-carrier-protein] synthase n=16 Tax=Eurotiomycetes TaxID=147545 RepID=Q4WHD8_ASPFU
A0A060TGL6_BLAAD	61.864%	354	4.49e-154	ARAD1D31614p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D31614g PE=3 SV=1
Q6BZV1_YARLI	52.668%	431	1.68e-143	3-oxoacyl-[acyl-carrier-protein] synthase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F30679g PE=3 SV=1
Q5ANC6_CANAL	49.774%	442	9.50e-141	3-oxoacyl-[acyl-carrier-protein] synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CEM1 PE=3 SV=1
A0A1E4TK30_9ASCO	45.521%	413	1.10e-104	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20925 PE=3 SV=1
CEM1_YEAST	42.793%	444	2.59e-108	3-oxoacyl-[acyl-carrier-protein] synthase homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CEM1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6419

Protein family membership

3-oxoacyl-[acyl-carrier-protein] synthase 2 (IPR017568)

Domains and repeats

Domain
5 - 445
Thiolase-like (IPR016039)
Domain
5 - 263
Beta-ketoacyl synthase, N-terminal (IPR014030)
271 - 400
Beta-ketoacyl synthase, C-terminal (IPR014031)
Domain
7 - 447
Polyketide synthase, beta-ketoacyl synthase domain (IPR020841)

1 50 100 150 200 250 300 350 400 447

Detailed signature matches

IPR017568

3-oxoacyl-[acyl-carrier-protein] synthase 2
1. TIGR03150
  
  5 - 443
  
  TIGRFAMs
  TIGR03150 (TIGR03150)
2. PIRSF000447 (KAS_II)
  
  2 - 447
  
  PIRSF
  PIRSF000447 (KAS_II)
IPR014030

Beta-ketoacyl synthase, N-terminal
1. PF00109 (ketoacyl-synt)
  
  5 - 263
  
  Pfam
  PF00109 (ketoacyl-synt)
IPR016039

Thiolase-like
1. SSF53901 (Thiolase-...)
  
  5 - 268
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
  
  231 - 445
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
2. G3DSA:3.40.47.10
  
  7 - 276
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
  
  277 - 445
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
IPR020841

Polyketide synthase, beta-ketoacyl synthase domain
1. SM00825 (PKS_KS)
  
  7 - 447
  
  SMART
  SM00825 (PKS_KS)
IPR014031

Beta-ketoacyl synthase, C-terminal
1. PF02801 (Ketoacyl-s...)
  
  271 - 400
  
  Pfam
  PF02801 (Ketoacyl-synt_C)
IPR018201

Beta-ketoacyl synthase, active site
1. PS00606 (B_KETOACYL...)
  
  170 - 186
  
  PROSITE patterns
  PS00606 (B_KETOACYL_SYNTHASE)

no IPR

Unintegrated signatures

NON_CYTOPLASM... (N...)

26 - 447

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 25

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

19 - 25

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

7 - 18

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 6

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
TMhelix

7 - 29

TMHMM
TMhelix (TMhelix)
cd00834 (KAS_I_II)

5 - 442

CDD
cd00834 (KAS_I_II)

Residue annotation

dimer interface cd...

123G

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

130A

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

131V

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

135T

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

137F

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

138N

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

150I

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

156N

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

160G

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

164I

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

170G

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

172N

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

174S

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

175V

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

176S

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

188D

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

191N

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

192F

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

195L

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

216A

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

217G

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

220R

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

221A

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

280S

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

281G

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

282D

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

283A

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

284H

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

298R

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

434G

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)

436T

dimer interface
123G, 130A, 131V, 135T, 137F, 138N, 150I, 156N, 160G, 164I, 170G, 172N, 174S, 175V, 176S, 188D, 191N, 192F, 195L, 216A, 217G, 220R, 221A, 280S, 281G, 282D, 283A, 284H, 298R, 434G, 436T
CDD
cd00834 (KAS_I_II)
active site cd00834

179C

active site
179C, 320H, 372H
CDD
cd00834 (KAS_I_II)

320H

active site
179C, 320H, 372H
CDD
cd00834 (KAS_I_II)

372H

active site
179C, 320H, 372H
CDD
cd00834 (KAS_I_II)

Protein sequence

>MIA_03989_1
MSQLRRVVVTGLGVVSPLGVGVSHAWANLIAGKSGLVSLDSTVLANHPDVPCRVGGQVPVGSAADGKWDALEWVDKPSLR
RVPTFAQYTLAATKQALDDAQWSPATSENPLDQERTGVCVGSGIGGFEDAVTNTTAFNAGGYRKIQPLFIPRLLANMAAG
HISINHKLKGPNHSVSTACTTGAHAIGDAANFISLGMADVMVAGSGEASLHPIALAGFARAKSVATAFNDNPEAASRPFD
KRRAGFIMGEGAGIFVLEELEHAQARGAKIYAEVVGYGLSGDAHHITAPAESGDGARRSMQMAIDRSGVAPKSIGYVNAH
ATSTKLGDVAENNAICEVLLGSSNPAKASSPQKFKNSPGEINVSSSKASMGHLLGGAGSVEALFTVLALRDNVLPPTRNL
DDPEEGFECNYVPHVAQTPKEPLEYAITNSFGFGGTNASLLFKKWTN

GO term prediction

Biological Process

GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.

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Entry type

Status

Per-residue features