MCA_02171_1

Protein

Length

444 amino acids

Gene name: CEM1

Description: 3-oxoacyl-[acyl-carrier-protein] synthase homolog

Browser: contigB:464426-465761-

RNA-seq: read pairs 1487, FPKM 41.3, percentile rank 61.0% (100% = highest expression)

Protein function

Annotation:		CEM1	3-oxoacyl-[acyl-carrier-protein] synthase homolog
KEGG:	K09458	fabF	3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
EGGNOG:	0PFCF	CEM1	3-oxoacyl- acyl-carrier-protein -synthase
SGD closest match:	S000000863	CEM1	3-oxoacyl-[acyl-carrier-protein] synthase homolog
CGD closest match:	CAL0000200784	CEM1	3-oxoacyl-[acyl-carrier-protein] synthase

Protein alignments

	%id	Aln length	E-value
MIA_03989_1	71.08%	446	0.0	MIA_03989_1
A0A0J9XK02_GEOCN	62.50%	440	0.0	3-oxoacyl-[acyl-carrier-protein] synthase OS=Geotrichum candidum GN=BN980_GECA24s00934g PE=3 SV=1
A0A1E3PSZ5_9ASCO	57.40%	446	0.0	3-oxoacyl-[acyl-carrier-protein] synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48595 PE=3 SV=1
A0A167FEZ7_9ASCO	54.85%	443	4e-173	3-oxoacyl-[acyl-carrier-protein] synthase OS=Sugiyamaella lignohabitans GN=CEM1 PE=3 SV=1
UniRef50_K0KAB1	54.71%	446	3e-167	3-oxoacyl-[acyl-carrier-protein] synthase n=14 Tax=Saccharomycetales TaxID=4892 RepID=K0KAB1_WICCF
Q6BZV1_YARLI	53.18%	440	2e-158	3-oxoacyl-[acyl-carrier-protein] synthase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F30679g PE=3 SV=1
Q5ANC6_CANAL	50.00%	458	6e-150	3-oxoacyl-[acyl-carrier-protein] synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CEM1 PE=3 SV=1
A0A060TGL6_BLAAD	61.25%	351	9e-150	ARAD1D31614p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D31614g PE=3 SV=1
CEM1_YEAST	45.55%	461	2e-120	3-oxoacyl-[acyl-carrier-protein] synthase homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CEM1 PE=1 SV=1
A0A1E4TK30_9ASCO	44.99%	429	5e-106	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20925 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3620

Protein family membership

3-oxoacyl-[acyl-carrier-protein] synthase 2 (IPR017568)

Domains and repeats

Domain
1 - 273
Thiolase-like (IPR016039)
229 - 442
Thiolase-like (IPR016039)
Domain
5 - 260
Beta-ketoacyl synthase, N-terminal (IPR014030)
269 - 397
Beta-ketoacyl synthase, C-terminal (IPR014031)
Domain
7 - 444
Polyketide synthase, beta-ketoacyl synthase domain (IPR020841)

1 50 100 150 200 250 300 350 400 444

Detailed signature matches

IPR017568

3-oxoacyl-[acyl-carrier-protein] synthase 2
1. TIGR03150
  
  5 - 440
  
  TIGRFAMs
  TIGR03150 (TIGR03150)
2. PIRSF000447 (KAS_II)
  
  2 - 444
  
  PIRSF
  PIRSF000447 (KAS_II)
IPR016039

Thiolase-like
1. SSF53901 (Thiolase-...)
  
  5 - 264
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
  
  229 - 442
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
2. G3DSA:3.40.47.10
  
  1 - 273
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
  
  274 - 442
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
IPR014030

Beta-ketoacyl synthase, N-terminal
1. PF00109 (ketoacyl-synt)
  
  5 - 260
  
  Pfam
  PF00109 (ketoacyl-synt)
IPR020841

Polyketide synthase, beta-ketoacyl synthase domain
1. SM00825 (PKS_KS)
  
  7 - 444
  
  SMART
  SM00825 (PKS_KS)
IPR014031

Beta-ketoacyl synthase, C-terminal
1. PF02801 (Ketoacyl-s...)
  
  269 - 397
  
  Pfam
  PF02801 (Ketoacyl-synt_C)
IPR018201

Beta-ketoacyl synthase, active site
1. PS00606 (B_KETOACYL...)
  
  167 - 183
  
  PROSITE patterns
  PS00606 (B_KETOACYL_SYNTHASE)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 6

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
NON_CYTOPLASM... (N...)

27 - 444

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

7 - 26

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

7 - 26

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd00834 (KAS_I_II)

5 - 439

CDD
cd00834 (KAS_I_II)

Residue annotation

dimer interface cd...

110S

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

127C

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

128V

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

132T

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

134F

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

135N

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

147V

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

153N

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

157G

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

161I

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

167G

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

169N

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

171S

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

172P

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

173S

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

185D

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

188N

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

189L

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

192L

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

213A

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

214G

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

217R

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

218A

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

278S

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

279G

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

280D

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

281G

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

282H

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

296R

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

431G

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)

433T

dimer interface
110S, 127C, 128V, 132T, 134F, 135N, 147V, 153N, 157G, 161I, 167G, 169N, 171S, 172P, 173S, 185D, 188N, 189L, 192L, 213A, 214G, 217R, 218A, 278S, 279G, 280D, 281G, 282H, 296R, 431G, 433T
CDD
cd00834 (KAS_I_II)
active site cd00834

176C

active site
176C, 318H, 369H
CDD
cd00834 (KAS_I_II)

318H

active site
176C, 318H, 369H
CDD
cd00834 (KAS_I_II)

369H

active site
176C, 318H, 369H
CDD
cd00834 (KAS_I_II)

Protein sequence

>MCA_02171_1
MNPSRRVVITGIGIVSPLGVGLSHVWKALIAGQSGIVSLDKTILANHPDVPCRIGGQVPLGSKSEGKWDASEWIEKAQLR
RLPLFAQYAIAATQQALEDSNWFPQDYEDSILTGVSVGSGIGGFEDCVQNVTAFNSGGYKKVSPLFVPRLLCNMAAGNIS
IKYGFKGPNISPSTACTTGAHAIGDAANLISLGMADVMVAGSSEASLHPLSLAGFSRAKSVSTHFNDTPTQASRPFDKQR
NGFVMGEGAGVMILEELEHAKARGVQTIYGEVVGYGMSGDGHHITAPPEDGDGARRSMQMAIKRAGIKPSQVGYVNAHAT
STKIGDVAENAAICKVLMGNEEQQKALPGYFKQSPKEINISSSKGSIGHLLGGAGAVEAIFTAMALKDNVLPPTLNLEEP
EDGFECNYVPKESQVPETPIEYAMSNSFGFGGTNASLLLKRWEA

GO term prediction

Biological Process

GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.

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Entry type

Status

Per-residue features