Protein

MIA_03971_1

Length
2,410 amino acids

Browser: contig05:381234-388467-

Protein function

EGGNOG:0PHSRPRP8factor 8
SGD closest match:S000001208PRP8Pre-mRNA-splicing factor 8
CGD closest match:CAL0000198077PRP8U4/U6-U5 snRNP complex subunit

Protein alignments

%idAln lengthE-value
MCA_02165_288.575%23370.0MCA_02165_2
A0A0J9XBM7_GEOCN84.489%23080.0Similar to Saccharomyces cerevisiae YHR165C PRP8 Component of the U4/U6-U5 snRNP complex OS=Geotrichum candidum GN=BN980_GECA07s01220g PE=4 SV=1
A0A060T7Z1_BLAAD78.393%23280.0ARAD1D03102p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D03102g PE=4 SV=1
A0A1E3PKA9_9ASCO75.645%23240.0PROCN-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51141 PE=4 SV=1
Q6CCC5_YARLI71.102%23220.0YALI0C10648p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C10648g PE=4 SV=2
UniRef50_Q6CCC571.102%23220.0YALI0C10648p n=25 Tax=cellular organisms TaxID=131567 RepID=Q6CCC5_YARLI
A0A1E4TB19_9ASCO68.675%23240.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_65636 PE=4 SV=1
Q5A322_CANAL67.364%23410.0U4/U6-U5 snRNP complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRP8 PE=4 SV=1
PRP8_YEAST64.959%23430.0Pre-mRNA-splicing factor 8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP8 PE=1 SV=1
A0A167EEA5_9ASCO82.392%18060.0U4/U6-U5 snRNP complex component PRP8 OS=Sugiyamaella lignohabitans GN=PRP8 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5317
Predicted cleavage: 52

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 500 1000 1500 2000 2410

Detailed signature matches

  1. Domain IPR012591
    PRO8NT domain
    1. PF08082 (PRO8NT)
    2. PD149576
  2. Domain IPR012592
    PROCN domain
    1. PF08083 (PROCN)
  3. Domain IPR019582
    RNA recognition motif, spliceosomal PrP8
    1. PF10598 (RRM_4)
  4. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
  5. Domain IPR019581
    Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
    1. PF10597 (U5_2-snRNA...)
  6. Domain IPR019580
    Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
    1. PF10596 (U6-snRNA_bdg)
  7. Domain IPR021983
    PRP8 domain IV core
    1. cd13838 (RNase_H_li...)
    2. PF12134 (PRP8_domainIV)
  8. Domain IPR000555
    JAB1/MPN/MOV34 metalloenzyme domain
    1. SM00232 (pad1_6)
    2. PF01398 (JAB)
  9. Domain IPR012984
    PROCT domain
    1. PF08084 (PROCT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd08056 (MPN_PRP8)
  2. mobidb-lite (disord...)

Residue annotation

  1. active site cd13838

Protein sequence

>MIA_03971_1
MSRAPPPPGWNRRATGPPPPPPGASRSSGPPPPPPPSASRPPPPPKSSNRTVPGPPPGAPPSAPPGAPPPPPKPPAPTTG
VDPKQLDARADQLSERKKKWIQLQKRRYGEQKGKSTYVHQAKIEMPPEHLRKIINDHGDMSTRKVAADKRSYLGALKYMP
HAVIKLLENMPQPWEQVREVRVLYHITGAITFVNETPRVIEPIYKAQWAVMWIAMRREKRDRRHFKRMNFPPFDDEEPPI
NWSENIEISEPSEAIELELNEEEDGAVIEWFYDHQPLIDDKKYVNGPSYRTWKLGLPEMAALHRLATPLLTDKTDRNYFY
LFNKEAFFTAKALNSAIPGGPKFEPLYKDVNPEDEDFGEFNTIDRIIFRRVIRTEYKVMYPHLYNSLPRSVHLTWYHDPQ
TCFKPAEDPELPPFYFHPTYEPISSRTVSAYRDEIPSFEEFDEEDDDDFTMPEDFETFLEEDTLATENTPSAINLWWAPY
PFNRRSGRTVRAEDVALVKHWYLEHPNTDYPVKVRVSYQKLLKTYVLNSLKTRPPANQRKRSLLKSLGNTKFFQETTIDW
VEAGLQLCRQGFTMLNLLIHRKGLTYLHLDYNFNLKPIKTLTTKERKRSRFGNAFHLMREILRIIKLIVDAHVQYRLGNV
DAYQLADGIYYILNHLGHLTGIHRYKYRVMHQIRTCKDLKHVVYYKFNVAIGKGPGAGFWQPAWRVWIFFLRGIIPLLER
WLGNLLARQFEGRHSKGIAKTITKQRVESYYDLELRTQVLSDIMDMIPEGIKQSKSKTILQHLSEAWRCWKANIPWKVPG
LPKPIEDIILRYIKAKADGWISVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKSEQERQYNFSKDGPYVSPEEAVAIY
SAMVKWLESRKFAPIPFPPLSYKHDTKLLVLALEGLKDSYNVKGRLNQSEREELALIEQAYDNPHECLSRIKRFLLTQRV
FKEVGLDMMDHYTHITPIYEVDPLEKITDAYLDQYLWYEGDRRNIFPNWVKPSDSEVPPLLVYKWCQGINNLKDVWDVSE
GQCNVMFQTTLSKVAEKIDFTLLNRLLRLIVDSNIADYITAKNNVNLSYKDMNHVNQYGLVRGLQFSSFVFQYYGLVLDI
ILLGLERASELAGPPSQPNDFLQFSDEETETSHPIRMYARYIDKIFIFYRFTAEEAKELNQRFLIENPDPNFENIIGYNN
KKCWPRDARMRLMRHDVNLGRAVFWQVRNSLPRSLTTINWEDTFASVYSKDNPNLLFSMVGFEVRILPKIRAEDMNLQTQ
DSVWDLIDEETKERTAYAFLRVSEEDIAKFRNRIRQILMSSGSTTFTKIANKWNTALISIFTYFREAAVATEELLDALVR
CETKIQTRVKIGLNSKMPSRFPPVVFYTPKELGGLGMLSASHILIPTSDLRWSKQTDTGITHFRAGMSHEEDQLIPNIFR
YLTSWESEFKDSQRVWAEYAMKRQEALQQNRRLTLEDLEDSWDRGLPRINTLFQKDRHTLAYDKGHRIRTEFRQYSIARV
NPFWWTSQRHDGKLWNLNAYRTDVIQALGGIETILEHTLFKGTGFDNWEGLFWEKAAGFEDSLKFKKLTNAQRSGLNQIP
NRRFTLWWSPTINRANVYVGFLVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVIFDLASVLDEEMDTLQIESVQ
KETIHPRKSYKMNSSTADIVVFSAYRWSVCKPSLLNDSKDNMDFATTNKFWIDVQLRYGDYDSHDISRYTRAKFLDYTSD
GISVYPSSTGIMIGIDLAYNMYDAYGNWFPGLKPLVKQAMSKIMKANPSLFVLRERIRKGLQLYQSQPQEAFLNSQNYSE
LFGKDIQFFVDDSNVYRVVTHKTYEGNMATKPINGALFIFNPRTGQLFLKIIHTSVWAGQKRMIQLSKWKTAEEVAALVR
TLPREEQPKQIIVTRKGMLDPLEVHMLDFPNISIRPSELQLPFSAAIKIEKLADQILKATEPEMLLYNLYDDWLIDNKTE
PGTAFSRLVLILRALHVNNEKAKIILRPDRTVVTQTYHLWPSYTIEQWVNVENQLSDLILNDYGKKNNVDPASLTQQEIR
DIILGQDIKAPSLRRQEIARIEQQEQEQSQLTAVKTRTQNVHGDEMVVVTTSNYEQQAFQSKTEWRSRAISTTNLHLRAK
HIFVSSEDIQDDDIHFTYVMPKNILKKFIQISDLRAQVAGLLYGLSPADNSKVKEIKAIALIPQLGNAHSVQLASHLPDP
SDPLLEGLEPLGWLHTQAQEQPFLSPVDVTAQAKLMNENPSWGANAITMTVSFTPGSVSLAAFSLSSEGLAWGAQNKDIF
SPSPEGFSTKFGEKCQLLLSDRIKGFFLVPDTNLWNFAFVGAGWSPSTKYDLKIDIPLPFYHELHRPIHFTTFTELENND
IGVDREDVYA

GO term prediction

Biological Process

GO:0000398 mRNA splicing, via spliceosome

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030623 U5 snRNA binding

Cellular Component

None predicted.