Protein

MIA_03968_1

Length
282 amino acids

Browser: contig05:374745-375594+

Protein function

EGGNOG:0PFBXMCR1May mediate the reduction of outer membrane cytochrome b5 (By similarity)
SGD closest match:S000001633MCR1NADH-cytochrome b5 reductase 2
CGD closest match:CAL0000182452MCR1NADH-cytochrome b5 reductase 2

Protein alignments

%idAln lengthE-value
UniRef50_L8GS9638.74%2533e-47NADH-cytochrome b5 reductase n=1 Tax=Acanthamoeba castellanii str. Neff TaxID=1257118 RepID=L8GS96_ACACA
MCR1_CANAL33.07%2511e-39NADH-cytochrome b5 reductase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MCR1 PE=3 SV=1
A0A060TCD8_BLAAD34.52%2521e-38NADH-cytochrome b5 reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38698g PE=3 SV=1
MCR1_YEAST31.35%2521e-35NADH-cytochrome b5 reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCR1 PE=1 SV=1
A0A1E4TD25_9ASCO30.36%2477e-35NADH-cytochrome b5 reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4288 PE=3 SV=1
MCR1_YARLI31.50%2542e-33NADH-cytochrome b5 reductase 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MCR1 PE=3 SV=1
A0A1E3PNU2_9ASCO31.73%2491e-31NADH-cytochrome b5 reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_41166 PE=3 SV=1
A0A167E869_9ASCO36.36%1763e-31Mcr1p OS=Sugiyamaella lignohabitans GN=MCR1 PE=4 SV=1
A0A0J9XBF9_GEOCN31.98%2224e-29NADH-cytochrome b5 reductase OS=Geotrichum candidum GN=BN980_GECA08s02144g PE=3 SV=1
MCA_01794_132.41%2532e-27MCA_01794_1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6881
Predicted cleavage: 40

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 282

Detailed signature matches

  1. Family IPR001834
    NADH:cytochrome b5 reductase (CBR)
    1. PR00406 (CYTB5RDTASE)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR008333
    Oxidoreductase, FAD-binding domain
    1. PF00970 (FAD_binding_6)
  5. Domain IPR001433
    Oxidoreductase FAD/NAD(P)-binding
    1. PF00175 (NAD_binding_1)
  6. Domain IPR001709
    Flavoprotein pyridine nucleotide cytochrome reductase
    1. PR00371 (FPNCR)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.30.10
  2. G3DSA:3.40.50.80
  3. NON_CYTOPLASM... (N...)
  4. SIGNAL_PEPTIDE (Sig...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SSF52343 (Ferredoxi...)
  9. cd06183 (cyt_b5_red...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. NAD binding pocket...
  4. phosphate binding ...
  5. beta-alpha-beta st...

Protein sequence

>MIA_03968_1
MITPKTIIAVGAISIVGGYAISKRCGSSKVAFSFPPYRMTPIELVEATRLTPDVQHYRFKLPSSDSPTIPVTAPMLIKTS
AGIRPFTPFYNDSDPGYINFAIKNYNRGVSKSVSDLLPGDKVKLAGPLPHVDMEGTTAKYDQVYLIGAGSGLTPLWSYLN
ATLNDPLSQTKLKLIYANKTKEDIIFKNEMEKLKAQYPDRFEVVHVLEQPDDVAKYTGRLTGDIIKKEVGLPGNNNKVLV
CGPPKFIETVAGPKKRAPPFVQGTFGGVLKDIGFIQSQVVKY

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.