Protein

MCA_01794_1

Length
317 amino acids

Gene name: MCR1

Description: NADH-cytochrome b5 reductase 2; mitochondrial

Browser: contigA:5476052-5477130+

RNA-seq: read pairs 19653, FPKM 763.6, percentile rank 95.8% (100% = highest expression)

Protein function

Annotation:MCR1NADH-cytochrome b5 reductase 2; mitochondrial
KEGG:K00326E1.6.2.2 cytochrome-b5 reductase [EC:1.6.2.2]
EGGNOG:0PFBXMCR1May mediate the reduction of outer membrane cytochrome b5 (By similarity)
SGD closest match:S000001633MCR1NADH-cytochrome b5 reductase 2
CGD closest match:CAL0000182452MCR1NADH-cytochrome b5 reductase 2

Protein alignments

%idAln lengthE-value
MIA_02392_173.10%2902e-143MIA_02392_1
A0A0J9X4V5_GEOCN72.62%2631e-136NADH-cytochrome b5 reductase OS=Geotrichum candidum GN=BN980_GECA02s06687g PE=3 SV=1
A0A060TCD8_BLAAD61.18%2557e-114NADH-cytochrome b5 reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38698g PE=3 SV=1
A0A1E3PNU2_9ASCO55.33%2919e-113NADH-cytochrome b5 reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_41166 PE=3 SV=1
MCR1_YARLI56.45%2871e-109NADH-cytochrome b5 reductase 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MCR1 PE=3 SV=1
MCR1_CANAL57.77%2518e-99NADH-cytochrome b5 reductase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MCR1 PE=3 SV=1
UniRef50_A5E5C554.38%2745e-93NADH-cytochrome b5 reductase 2 n=15 Tax=Saccharomycetales TaxID=4892 RepID=MCR1_LODEL
A0A1E4TC39_9ASCO49.81%2677e-91Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14593 PE=4 SV=1
MCR1_YEAST47.51%2618e-84NADH-cytochrome b5 reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCR1 PE=1 SV=1
A0A167E869_9ASCO55.81%1724e-71Mcr1p OS=Sugiyamaella lignohabitans GN=MCR1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9988
Predicted cleavage: 23

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 317

Detailed signature matches

  1. Family IPR001834
    NADH:cytochrome b5 reductase (CBR)
    1. PR00406 (CYTB5RDTASE)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR008333
    Oxidoreductase, FAD-binding domain
    1. PF00970 (FAD_binding_6)
  5. Domain IPR001433
    Oxidoreductase FAD/NAD(P)-binding
    1. PF00175 (NAD_binding_1)
  6. Domain IPR001709
    Flavoprotein pyridine nucleotide cytochrome reductase
    1. PR00371 (FPNCR)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.30.10
  2. G3DSA:3.40.50.80
  3. SSF52343 (Ferredoxi...)
  4. cd06183 (cyt_b5_red...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. NAD binding pocket...
  4. phosphate binding ...
  5. beta-alpha-beta st...

Protein sequence

>MCA_01794_1
MNFGSSSLRQFARGASRSIRSYSSAASAPLKSSWGPFVAGAGAAALGAYYFYSTQSPVAAESALKGDKQWVDFKLAEVKD
LTSNTKEFVFELPADQTLGLKYTSCILAKYVTAKGNNVIRPYTPVSDINETGAFRLIIKRYETGKFGNHIFGLKLGDTVS
FQGPIPKYPYSANQHKQLGLIGGGSGITPLYQLIHAVDSNPADKTTVHLFYGNVSENDIILKKELEDIAAKKPEQFKFHF
FVDKAGPSWKGQSGFITKEYIEKNMFSPSDENVKVFVCGPPPLYNAASGNKVSPTDQGELTGFLKELGFSKDQVYKF

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.