Protein

MIA_03953_1

Length
847 amino acids

Browser: contig05:350149-352693-

Protein function

EGGNOG:0PGUFRRP6exosome complex exonuclease Rrp6
SGD closest match:S000005527RRP6Exosome complex exonuclease RRP6
CGD closest match:CAL0000183418RRP6Exosome nuclease subunit

Protein alignments

%idAln lengthE-value
MCA_02283_150.117%8580.0MCA_02283_1
A0A0J9X9R2_GEOCN45.120%7070.0Similar to Saccharomyces cerevisiae YOR001W RRP6 Nuclear exosome exonuclease component OS=Geotrichum candidum GN=BN980_GECA05s03563g PE=4 SV=1
UniRef50_A0A0J9X9R245.120%7070.0Similar to Saccharomyces cerevisiae YOR001W RRP6 Nuclear exosome exonuclease component n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9R2_GEOCN
A0A167FUJ0_9ASCO45.942%6161.47e-174Exosome nuclease subunit RRP6 OS=Sugiyamaella lignohabitans GN=RRP6 PE=4 SV=1
A0A060T169_BLAAD43.354%6328.01e-155ARAD1C22000p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C22000g PE=4 SV=1
A0A1D8PDF4_CANAL44.737%5329.83e-149Exosome nuclease subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RRP6 PE=4 SV=1
Q6C721_YARLI45.547%4947.63e-138YALI0E04444p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E04444g PE=4 SV=1
RRP6_YEAST41.509%5301.55e-135Exosome complex exonuclease RRP6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRP6 PE=1 SV=1
A0A1E4TMD8_9ASCO43.236%3773.87e-102Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_11487 PE=4 SV=1
A0A1E3PRC2_9ASCO43.947%3804.68e-91Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80988 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2941
Predicted cleavage: 19

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 847

Detailed signature matches

  1. Domain IPR012588
    Exosome-associated factor Rrp6, N-terminal
    1. PF08066 (PMC2NT)
  2. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  3. Domain IPR002562
    3'-5' exonuclease domain
    1. PF01612 (DNA_pol_A_...)
    2. SM00474 (35exoneu6)
  4. Domain IPR010997
    HRDC-like
    1. SSF47819 (HRDC-like)
  5. Domain IPR002121
    HRDC domain
    1. SM00341 (hrdc7)
    2. PF00570 (HRDC)
    3. PS50967 (HRDC)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.15...
  3. NON_CYTOPLASM... (N...)
  4. SIGNAL_PEPTIDE (Sig...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. cd06147 (Rrp6p_like...)
  9. mobidb-lite (disord...)

Residue annotation

  1. putative active si...
  2. catalytic site cd0...
  3. putative substrate...

Protein sequence

>MIA_03953_1
MAEKHKPVFTALQSTIRAASGVAAQDISFYRRLDKPLDQSAKKQSEKLLGLANYIMQNVAKGEVDEIAAEDTADDLTDSW
HEVNVALDTLTFKIDNCLATHKKQQKKEDSKAAVADDGEKKPGEMIKITDGRSQTSGEVKRHQFDLPKPQLQFKTPVDNS
KDKPFHPRLTEKPNAIIPFEEAVKLTEPSEENGLARPYFPQPYEREIMESPYPTTVYKKHDPVPSLPWSTTEPIWIDTPE
KLQKMIDQISSATEIALDLEHHDYRSFLGFTCLLQLSDRKSDFIVDTLALRDDLLPLNKIFTNPKIVKVLHGASMDIIWL
QRDLGLYIVSLFDTFHASKKLGLKRHALAYLLETYANFQTSKKYQLADWRMRPIPAEMLSYAQSDTHFLLNIYDQMKNQL
IDNNVLPPVLEESRKTAAQRFENPGYDTSKKALTDPFNEPLDRLIFKNNLDRKQRVFLEALYEWRDNTARRIDESPSFVM
PVHTLIALSSAMPLTVSEILHKAGPQGSRLREYSKELQKLMVAASKAAANISETEPIEAVDVTSTLSAGVVDYDSILDNL
DAYEKSFKTALGLQRSLFDEKNISKITNKLIKPVSQFWGVTLLSLPNSPEDDTQFFPIEHFPEGITLYAGSVGRSTQQSE
ETPEQQPQKTETPDDRETVFIGQSSETKALSSTMDAIREQDSKSRSADTILMPTAAELLGSGLRLLTKNEKKKIKREKRR
ADALEAGEQTASSETVTPEPEGSSNKNKNKNKRKKNKRSVSEFNNEEDHSEGTSPKKVKKDDDEPFDFATAPSVLNSIDD
GKSKKKKKAFNPYAEINPTFSGAVKKNVATQINANTSVSYKLKSHKK

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process
GO:0006396 RNA processing
GO:0044237 cellular metabolic process

Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003824 catalytic activity
GO:0008408 3'-5' exonuclease activity

Cellular Component

GO:0000176 nuclear exosome (RNase complex)
GO:0005622 intracellular