Protein

MIA_03905_1

Length
785 amino acids

Browser: contig05:214643-217241-

Protein function

EGGNOG:0PHPDBUR1Serine threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2 RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity)
SGD closest match:S000006365SGV1Serine/threonine-protein kinase BUR1
CGD closest match:CAL0000191033CRK1Serine/threonine-protein kinase BUR1

Protein alignments

%idAln lengthE-value
MCA_03387_161.914%4910.0MCA_03387_1
A0A0J9X2S2_GEOCN66.571%3502.47e-166Similar to Saccharomyces cerevisiae YPR161C SGV1 Cyclin (Bur2p)-dependent protein kinase OS=Geotrichum candidum GN=BN980_GECA01s09657g PE=4 SV=1
UniRef50_A0A0J9X2S266.571%3505.05e-163Similar to Saccharomyces cerevisiae YPR161C SGV1 Cyclin (Bur2p)-dependent protein kinase n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X2S2_GEOCN
A0A167DX62_9ASCO57.967%3647.42e-140Cyclin-dependent serine/threonine protein kinase SGV1 OS=Sugiyamaella lignohabitans GN=SGV1 PE=4 SV=1
BUR1_YARLI54.648%3552.32e-130Serine/threonine-protein kinase BUR1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=BUR1 PE=3 SV=1
A0A060TBJ1_BLAAD58.140%3441.33e-132ARAD1B08228p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08228g PE=3 SV=1
A0A1E3PJG7_9ASCO54.972%3622.32e-132Pkinase-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_24507 PE=3 SV=1
A0A1E4TJQ9_9ASCO56.305%3415.93e-132Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22937 PE=3 SV=1
BUR1_CANAL49.462%3724.40e-107Serine/threonine-protein kinase BUR1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CRK1 PE=3 SV=3
BUR1_YEAST49.438%3561.33e-98Serine/threonine-protein kinase BUR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SGV1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1179

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 785

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd07866 (STKc_BUR1)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd07866
  3. CDK/cyclin interfa...
  4. polypeptide substr...
  5. activation loop (A...

Protein sequence

>MIA_03905_1
MSKGRLENRSTASRRDSFKQKKNDSEDDLMPHVLENTRASDRDQRLKPYSPSHEDDVQERETIQNSGSEKVFSFKNASVS
SSKLKSNIENDSQEDLKAKSPSSENNNKAEPQSNLVNEPNSSKRDSPHESKFPSISPSYQSTTRESNENNIDINKPHKIS
STNEAKKSLTSSTDADSSAPLKEQNRHDSPDGKTDSSSTPSAREFKFLSAASEKNSTPPTHSNDTPPSFTNTSSGASTPV
NRCPWTFYGCSNVTSEYRMFDKLGEGTFGEVHKGEKQSNGLKVALKRIFLHNEKEGFPITALREIRILKSLDHPNIIPIL
DMAVQHGDRTRKQRGSVYMVTPYMDHDLAGLLGNPNVHLELPHIKCYMKQLLEGMKYLHDQQYLHRDIKSANILIDNWGN
LRIADFGLARSYIEPHPVKGSGPGKGTRTYTSMVVTRWYRAPELVLGESKYTTSVDMWGVGCVFSEMFVRRPILQGTSDS
DQAHCIFKLLGTPTQETMPGFDKLPGGQINFTYRRTLEQRFNELDVPTISLLSNLLRLDPLKRITAVDALDHVFFRSDPK
PCRPQDLPKYNDSHEMDTRKSASEKNRQEQRPPVPHSQNSHLEPHSNFSPPRNSQQAQGPPYESSNGYQRLQPPYKQHQH
QKHPHAPFRSQPPLPPSAPYDRPLPPYRKSQQPEYSDSDRGNRKSRLHAQEKSPFYGNQGSNLTPRKRRSSLENTSFSGD
EAPVSSAPHLPPKPHIETSRLQKRSRPSSNEDEKNHQEIKPIEESSKESFSNPKKDNDKNDEQDS

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.