Protein

MCA_03387_1

Length
644 amino acids

Gene name: SGV1

Description: Cyclin-dependent serine/threonine protein kinase SGV1; In S. cerevisiae cyclin (Bur2p)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation.

Browser: contigB:4283373-4285308+

RNA-seq: read pairs 867, FPKM 16.6, percentile rank 36.4% (100% = highest expression)

Protein function

Annotation:SGV1Cyclin-dependent serine/threonine protein kinase SGV1; In S. cerevisiae cyclin (Bur2p)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation.
KEGG:K15562BUR1 serine/threonine-protein kinase BUR1 [EC:2.7.11.22 2.7.11.23]
EGGNOG:0PHPDBUR1Serine threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2 RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity)
SGD closest match:S000006365SGV1Serine/threonine-protein kinase BUR1
CGD closest match:CAL0000191033CRK1Serine/threonine-protein kinase BUR1

Protein alignments

%idAln lengthE-value
MIA_03905_166.13%4340.0MIA_03905_1
A0A0J9X2S2_GEOCN69.94%3462e-175Similar to Saccharomyces cerevisiae YPR161C SGV1 Cyclin (Bur2p)-dependent protein kinase OS=Geotrichum candidum GN=BN980_GECA01s09657g PE=4 SV=1
UniRef50_A0A0J9X2S269.94%3463e-172Similar to Saccharomyces cerevisiae YPR161C SGV1 Cyclin (Bur2p)-dependent protein kinase n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X2S2_GEOCN
A0A060TBJ1_BLAAD58.08%3653e-136ARAD1B08228p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08228g PE=3 SV=1
A0A167DX62_9ASCO61.54%3387e-134Cyclin-dependent serine/threonine protein kinase SGV1 OS=Sugiyamaella lignohabitans GN=SGV1 PE=4 SV=1
A0A1E3PJG7_9ASCO55.27%3515e-133Pkinase-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_24507 PE=3 SV=1
BUR1_YARLI55.12%3617e-127Serine/threonine-protein kinase BUR1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=BUR1 PE=3 SV=1
A0A1E4TJQ9_9ASCO55.72%3413e-129Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22937 PE=3 SV=1
BUR1_CANAL49.32%3672e-111Serine/threonine-protein kinase BUR1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CRK1 PE=3 SV=3
BUR1_YEAST48.01%3521e-99Serine/threonine-protein kinase BUR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SGV1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0072

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 644

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd07866 (STKc_BUR1)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd07866
  3. CDK/cyclin interfa...
  4. polypeptide substr...
  5. activation loop (A...

Protein sequence

>MCA_03387_1
MNDEKEQNLSNHEQINHLDQKSINSPNSHDSETLKKQSKSNSNEASSNGNENGKKTTNNLNDENSTKPNPRSPNADSQTK
ELSRDKQPFDDKPIKDSKNGIGSKESSNGNSNIKNTQIRFLSAATDPNVAASNTRLISKASSPRSPGNLTPKKGGHWTFY
GCSHVSSEYRMLDKLGEGTFGEVHKAEQISTGYIVALKRIFLHNEKEGFPITALREIRILKSLDHPNIIPIIDMATQRGD
RAQRKRGSVYMVTPYMEHDLAGLLGNPSVRLKLPHIKCYMKQMFEGMKYLHDQKFLHRDIKSANILIDNMGNLRIADFGL
ARHYEEPAPKPGSGAGKGKRSYTGMVVTRWYRAPELVLGESHYTTAIDMWGIGCVFGEMFKKSPILQGNSDSDQAHCIFK
LVGSPTEESMPGYSKLPGGLVEYSYRRTLEERFQELDPTSMSLLSAMLRLDPQRRITAVDALSHPFFTADPKPCLPEELP
KYNDSHELDARKSRKERNAKAEQDFYLHDTGNQHYQNNQRHSQPSHNNYYDSHSNNNYRNSHRPQPPYRSRMPISESNHA
PINGSRNHHPSRSSRPMPPYRNQSLNYSDSSSPYPKGPYRRNSNSNSNPHSNSNSTSTSRTGTPQGVHHTASLPPRPRHN
DEKN

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.