MIA_03894_1

Protein

Length

1,038 amino acids

Protein function

EGGNOG:	0PGZA	GCV2	glycine dehydrogenase
SGD closest match:	S000004801	GCV2	Glycine dehydrogenase (decarboxylating), mitochondrial
CGD closest match:	CAL0000198461	GCV2	Glycine cleavage system P protein

Protein alignments

	%id	Aln length
MCA_04682_1	79.671%	974	MCA_04682_1
A0A0J9X2V5_GEOCN	76.440%	972	Glycine cleavage system P protein OS=Geotrichum candidum GN=BN980_GECA01s10845g PE=3 SV=1
A0A167C0F7_9ASCO	68.937%	969	Glycine cleavage system P protein OS=Sugiyamaella lignohabitans GN=GCV2 PE=3 SV=1
A0A1E3PGI4_9ASCO	70.126%	954	Glycine cleavage system P protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26772 PE=3 SV=1
A0A060T2A4_BLAAD	66.356%	966	Glycine cleavage system P protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A06710g PE=3 SV=1
Q6CHE0_YARLI	66.496%	976	Glycine cleavage system P protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A09856g PE=3 SV=1
A0A1E4TJZ4_9ASCO	64.736%	967	Glycine cleavage system P protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_675 PE=3 SV=1
UniRef50_A0A1B8GU89	62.274%	994	Glycine cleavage system P protein n=19 Tax=leotiomyceta TaxID=716546 RepID=A0A1B8GU89_9PEZI
GCSP_YEAST	61.071%	971	Glycine dehydrogenase (decarboxylating), mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCV2 PE=1 SV=1
A0A1D8PE97_CANAL	59.692%	975	Glycine cleavage system P protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GCV2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9878
Predicted cleavage: 51

Protein family membership

Glycine cleavage system P protein (IPR020581)
- Glycine dehydrogenase (decarboxylating) (IPR003437)

Domains and repeats

Domain
78 - 511
Pyridoxal phosphate-dependent transferase (IPR015424)
536 - 965
Pyridoxal phosphate-dependent transferase (IPR015424)
1,009 - 1,032
Pyridoxal phosphate-dependent transferase (IPR015424)
Domain
160 - 409
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
410 - 516
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)
602 - 851
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
852 - 982
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)

1 100 200 300 400 500 600 700 800 900 1038

Detailed signature matches

IPR020581

Glycine cleavage system P protein
1. PF02347 (GDC-P)
  
  77 - 512
  
  Pfam
  PF02347 (GDC-P)
  
  553 - 817
  
  Pfam
  PF02347 (GDC-P)
2. cd00613 (GDC-P)
  
  128 - 512
  
  CDD
  cd00613 (GDC-P)
  
  558 - 951
  
  CDD
  cd00613 (GDC-P)
IPR003437

Glycine dehydrogenase (decarboxylating)
1. TIGR00461
  
  78 - 1,030
  
  TIGRFAMs
  TIGR00461 (TIGR00461)
2. MF_00711 (GcvP)
  
  69 - 1,036
  
  HAMAP
  MF_00711 (GcvP)
IPR015424

Pyridoxal phosphate-dependent transferase
1. SSF53383 (PLP-depen...)
  
  78 - 511
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
  
  536 - 965
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
  
  1,009 - 1,032
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
1. G3DSA:3.40.64...
  
  602 - 851
  
  GENE3D
  G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
  
  160 - 409
  
  GENE3D
  G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2
1. G3DSA:3.90.11...
  
  410 - 516
  
  GENE3D
  G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
  
  852 - 982
  
  GENE3D
  G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)

no IPR

Unintegrated signatures

Coil

1,035 - 1,038

COILS
Coil (Coil)
NON_CYTOPLASM... (N...)

36 - 1,038

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 35

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

31 - 35

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

21 - 30

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 20

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)

Residue annotation

tetramer interface...

128E

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

129S

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

133A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

134E

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

135L

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

138I

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

139A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

140S

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

141K

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

142N

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

152G

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

154F

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

156T

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

157H

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

158T

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

159P

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

160P

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

163Q

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

166I

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

174T

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

175S

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

176Y

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

178P

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

179Y

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

180Q

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

182E

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

185Q

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

186G

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

187R

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

189E

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

217A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

218A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

228F

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

242I

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

243Y

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

244P

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

245Q

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

248S

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

249V

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

251Q

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

252S

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

263V

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

293V

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

338Q

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

343P

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

344F

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

345G

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

346Y

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

347G

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

348G

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

349P

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

405Q

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

406A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

407L

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

413A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

417V

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

418Y

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

426D

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

429L

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

434L

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

436A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

444E

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

454T

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

475K

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

498E

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

499T

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

502A

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)

503S

tetramer interface
128E, 129S, 133A, 134E, 135L, 138I, 139A, 140S, 141K, 142N, 152G, 154F, 156T, 157H, 158T, 159P, 160P, 163Q, 166I, 174T, 175S, 176Y, 178P, 179Y, 180Q, 182E, 185Q, 186G, 187R, 189E, 217A, 218A, 228F, 242I, 243Y, 244P, 245Q, 248S, 249V, 251Q, 252S, 263V, 293V, 338Q, 343P, 344F, 345G, 346Y, 347G, 348G, 349P, 405Q, 406A, 407L, 413A, 417V, 418Y, 426D, 429L, 434L, 436A, 444E, 454T, 475K, 498E, 499T, 502A, 503S
CDD
cd00613 (GDC-P)
pyridoxal 5'-phosp...

151Q

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

216T

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

217A

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

220E

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

243Y

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

245Q

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

313A

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

336N

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

338Q

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)

339R

pyridoxal 5'-phosphate binding site
151Q, 216T, 217A, 220E, 243Y, 245Q, 313A, 336N, 338Q, 339R
CDD
cd00613 (GDC-P)
catalytic residue ...

339R

catalytic residue
339R
CDD
cd00613 (GDC-P)
tetramer interface...

558E

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

559T

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

563R

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

564Y

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

565M

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

568L

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

569Q

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

570S

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

571K

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

572D

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

585C

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

587M

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

589L

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

590N

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

591A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

592T

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

593T

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

596I

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

599T

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

605N

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

606I

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

607H

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

609F

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

610A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

611P

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

613D

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

616Q

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

617G

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

618Y

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

620E

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

646A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

647Q

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

657R

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

677A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

678H

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

679G

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

680T

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

683A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

684S

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

686A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

687M

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

694A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

733F

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

780H

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

786P

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

787H

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

788G

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

789G

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

790G

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

791G

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

792P

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

835S

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

836A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

837S

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

843W

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

847K

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

848L

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

856K

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

859K

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

864N

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

866N

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

874D

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

886L

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

911K

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

937E

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

938S

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

941L

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)

942A

tetramer interface
558E, 559T, 563R, 564Y, 565M, 568L, 569Q, 570S, 571K, 572D, 585C, 587M, 589L, 590N, 591A, 592T, 593T, 596I, 599T, 605N, 606I, 607H, 609F, 610A, 611P, 613D, 616Q, 617G, 618Y, 620E, 646A, 647Q, 657R, 677A, 678H, 679G, 680T, 683A, 684S, 686A, 687M, 694A, 733F, 780H, 786P, 787H, 788G, 789G, 790G, 791G, 792P, 835S, 836A, 837S, 843W, 847K, 848L, 856K, 859K, 864N, 866N, 874D, 886L, 911K, 937E, 938S, 941L, 942A
CDD
cd00613 (GDC-P)
pyridoxal 5'-phosp...

584S

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

645G

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

646A

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

649E

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

678H

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

680T

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

754D

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

778N

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

780H

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)

781K

pyridoxal 5'-phosphate binding site
584S, 645G, 646A, 649E, 678H, 680T, 754D, 778N, 780H, 781K
CDD
cd00613 (GDC-P)
catalytic residue ...

781K

catalytic residue
781K
CDD
cd00613 (GDC-P)

Protein sequence

>MIA_03894_1
MSSVGRSLLMASKAARMASRVSALRASSLVSRSSAIATTTSALQSSALRTTAATFSTSTRTLLATSSPLDPLDTFIRRHN
GSTGADVDTMLKTVGYSSVDAFISDVVPEDIRRADELQISPRNDGLSESQATAELKKIASKNKVLRSYIGQGYFGTHTPP
AIQRNILESPEWYTSYTPYQPEISQGRLESLLNFQTVVTDLTGLPIANASLLDEGTAAAEAVIMAFHFHREKRKTFYVDP
NIYPQTLSVVQSRAKLLGINLVVGLPPATSNPKEDYKDVLGAMVQYPAADGSVQQWSELADTLHQAGSLLTVASDLLALT
VLEPPAKFGADIVFGNSQRFGVPFGYGGPHAAFFATTDGEMRKMPGRLVGKSKDRLGNPAFRLALQTREQHIRREKATSN
ICTAQALLANMAAMYAVYHGPKGLKDIALRVHTLTAALATAINESSPHSVANSTYFDTLTINLANGQSADEFLAKAVQDY
EINLAKQGESTVSVSLDETVSASDLADLFKVFGAEITPEEAVSKLNLSVDGKFVAIPAEVARTSDILNYDVFNKYHTETE
LLRYMHLLQSKDISLANSMIPLGSCTMKLNATTEMIPITWPEFSNIHPFAPIDQAQGYAELTSQLEKDLAHITGFDATSL
QPNSGAQGEYTGLRVIRQYLESIGQGHRNVCLIPVSAHGTNPASAAMAGMKVVAVKCTANGELDLKDLLAKAEKNKDKLG
AIMITYPSTFGLFEPTVKKACEIVHEFGGQVYMDGANMNAQIGLTSPGTIGADVCHLNLHKTFCIPHGGGGPGVGPICVR
SHLQPFLPGHKLVDMSSSGITDKAIQSVCSAPWGSASILPIPWTYIKLTGGQGLTKATKVALLNANYMKARLADHYPILY
TNGNGLCGHEFIVDMRPFKATSGVEAIDIAKRLQDYGFHAPTMSFPVANTLMIEPTESESLAELDRFCDAMIQIRQEIKA
IEDGKIPQENNVLKNSPHTARDIIESDWSDRPYTREEAAYPLPYLKERKAWPTVARLDDTYGDLNLFCTCDPPKLDAE

GO term prediction

Biological Process

GO:0006544 glycine metabolic process
GO:0006546 glycine catabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0004375 glycine dehydrogenase (decarboxylating) activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features