MIA_03880_1

Protein

Length

332 amino acids

Browser: contig05:118312-119311+

Protein function

EGGNOG:	0PFIW	ZTA1	Quinone oxidoreductase
SGD closest match:	S000000250	ZTA1	Probable quinone oxidoreductase
CGD closest match:	CAL0000175885	orf19.2262	NADPH:quinone reductase

Protein alignments

	%id	Aln length	E-value
MCA_03423_1	71.83%	323	2e-162	MCA_03423_1
A0A0J9X5L3_GEOCN	57.80%	327	1e-120	Similar to Saccharomyces cerevisiae YBR046C ZTA1 NADPH-dependent quinone reductase OS=Geotrichum candidum GN=BN980_GECA02s05213g PE=4 SV=1
UniRef50_A0A0J9X5L3	57.80%	327	2e-117	Similar to Saccharomyces cerevisiae YBR046C ZTA1 NADPH-dependent quinone reductase n=72 Tax=Dikarya TaxID=451864 RepID=A0A0J9X5L3_GEOCN
A0A060TAN2_BLAAD	58.59%	326	2e-119	ARAD1D20988p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20988g PE=4 SV=1
QOR_YEAST	52.73%	330	3e-104	Probable quinone oxidoreductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZTA1 PE=1 SV=1
A0A167EY42_9ASCO	55.02%	329	2e-103	Zta1p OS=Sugiyamaella lignohabitans GN=ZTA1 PE=4 SV=1
Q59Z38_CANAL	53.17%	331	8e-101	NADPH:quinone reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2262 PE=4 SV=1
A0A1E3PMT2_9ASCO	51.19%	336	4e-100	NAD(P)-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82990 PE=4 SV=1
A0A1E4TC10_9ASCO	45.82%	323	2e-83	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_137045 PE=4 SV=1
Q6CEW4_YARLI	30.00%	230	5e-20	YALI0B12386p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12386g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1612

Protein family membership

None predicted.

Domains and repeats

Domain
9 - 157
GroES-like (IPR011032)
Alcohol dehydrogenase, N-terminal (IPR013154)
159 - 284
Alcohol dehydrogenase, C-terminal (IPR013149)
Domain
19 - 329
Polyketide synthase, enoylreductase domain (IPR020843)
Domain
119 - 286
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 332

Detailed signature matches

IPR011032

GroES-like
1. SSF50129 (GroES-like)
  
  9 - 157
  
  SUPERFAMILY
  SSF50129 (GroES-like)
IPR020843

Polyketide synthase, enoylreductase domain
1. SM00829 (PKS_ER_nam...)
  
  19 - 329
  
  SMART
  SM00829 (PKS_ER_names_mod)
IPR013154

Alcohol dehydrogenase, N-terminal
1. PF08240 (ADH_N)
  
  38 - 95
  
  Pfam
  PF08240 (ADH_N)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  119 - 286
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR013149

Alcohol dehydrogenase, C-terminal
1. PF00107 (ADH_zinc_N)
  
  159 - 284
  
  Pfam
  PF00107 (ADH_zinc_N)
IPR002364

Quinone oxidoreductase/zeta-crystallin, conserved site
1. PS01162 (QOR_ZETA_C...)
  
  148 - 169
  
  PROSITE patterns
  PS01162 (QOR_ZETA_CRYSTAL)

no IPR

Unintegrated signatures

G3DSA:3.90.18...

1 - 332

GENE3D
G3DSA:3.90.180.10 (G3DSA:3.90.180.10)
cd05286 (QOR2)

11 - 331

CDD
cd05286 (QOR2)

Residue annotation

NADP binding site ...

50N

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

51F

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

55Y

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

130L

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

134T

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

137T

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

155A

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

158G

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

159G

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

160T

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

179V

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

180S

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

184K

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

199Y

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

223G

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

224V

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

245F

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

246G

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

247N

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

248A

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

249S

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

269R

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

270P

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

271T

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

272L

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

319F

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)

321G

NADP binding site
50N, 51F, 55Y, 130L, 134T, 137T, 155A, 158G, 159G, 160T, 179V, 180S, 184K, 199Y, 223G, 224V, 245F, 246G, 247N, 248A, 249S, 269R, 270P, 271T, 272L, 319F, 321G
CDD
cd05286 (QOR2)
dimer interface cd...

142A

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

238R

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

239K

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

252V

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

253P

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

254P

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

255V

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

256S

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

257L

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

264N

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

265L

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

266K

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

267I

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

268L

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

269R

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

270P

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

271T

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

274N

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

275Y

dimer interface
142A, 238R, 239K, 252V, 253P, 254P, 255V, 256S, 257L, 264N, 265L, 266K, 267I, 268L, 269R, 270P, 271T, 274N, 275Y
CDD
cd05286 (QOR2)

Protein sequence

>MIA_03880_1
MSAPTIPATQKAIRIHETGDFDVVKYDTDVAVPEVSDTQILVKNAYAGINFIENYFRIGLYPASYPLTLGREGSGEVVKV
GSKVTKFAVGDKVTYINPNAYAQYIVLEEAAKVLKNPEGVDLKLGAASLLQGLTALTFVKEAYEVKAGDYILVHAAAGGT
GSILVQLASHFGAHVIGTVSTPEKAKIAKENGAEYIINYKTEDTVERVKEITKGQGVIAVFDGVGKSTFETSLAALARKG
TFVSFGNASGAVPPVSLLSLSAKNLKILRPTLFNYIYTADEWKHYSELLFKLIADKVVRISVSHVYPLEKTRDGLRDLFE
GKTTGKLLVEIE

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity

Cellular Component