Protein

MIA_03831_1

Length
459 amino acids

Browser: contig04:2259970-2261350+

Protein function

EGGNOG:0PFGTFG07468.1d-3-phosphoglycerate dehydrogenase
SGD closest match:S000001336SER33D-3-phosphoglycerate dehydrogenase 2
CGD closest match:CAL0000190003SER33Phosphoglycerate dehydrogenase

Protein alignments

%idAln lengthE-value
MCA_05114_179.476%4580.0MCA_05114_1
A0A0J9XJ60_GEOCN74.336%4520.0Similar to Saccharomyces cerevisiae YER081W SER3 3-phosphoglycerate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA18s01418g PE=3 SV=1
Q5A3K7_CANAL70.370%4590.0Phosphoglycerate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SER33 PE=3 SV=1
A0A060T4U0_BLAAD68.980%4610.0ARAD1C00550p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C00550g PE=3 SV=1
UniRef50_A3LPQ268.913%4600.03-phosphoglycerate dehydrogenase, serine biosynthesis n=302 Tax=Fungi TaxID=4751 RepID=A3LPQ2_PICST
A0A161HNM6_9ASCO68.410%4590.0Phosphoglycerate dehydrogenase SER33 OS=Sugiyamaella lignohabitans GN=SER33 PE=3 SV=1
A0A1E3PFB8_9ASCO66.739%4630.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28004 PE=3 SV=1
SER33_YEAST67.699%4520.0D-3-phosphoglycerate dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SER33 PE=1 SV=1
Q6C284_YARLI67.756%4590.0YALI0F09966p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09966g PE=4 SV=1
A0A1E4TFF9_9ASCO64.135%4740.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31443 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6504
Predicted cleavage: 38

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 459

Detailed signature matches

  1. Domain IPR006139
    D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
    1. PF00389 (2-Hacid_dh)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR006140
    D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
    1. PF02826 (2-Hacid_dh_C)
  4. Domain IPR002912
    ACT domain
    1. PS51671 (ACT)
  5. SITE IPR029752
    D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
    1. PS00065 (D_2_HYDROX...)
  6. SITE IPR029753
    D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
    1. PS00671 (D_2_HYDROX...)
    2. PS00670 (D_2_HYDROX...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.70...
  2. G3DSA:3.40.50...
  3. SSF52283 (Formate/g...)
  4. SSF55021 (ACT-like)
  5. cd04901 (ACT_3PGDH)
  6. cd12176 (PGDH_3)
  7. mobidb-lite (disord...)

Residue annotation

  1. ligand binding sit...
  2. NAD binding site c...
  3. tetramer interface...
  4. catalytic site cd1...
  5. L-serine binding s...
  6. ACT domain interfa...

Protein sequence

>MIA_03831_1
MSSPINVVSTSPAQGSHVGSPSGSFGRRRLSYTGTREHRALKPFSTSDIKVLLLENVHQNAVEAFKSQGYQVEFYKSALP
EEDLIDKIKDVHVVGIRSKTQLNEKVLKAAQNLIVIGCFCIGTNQVALDFAASKGIAVFNSPFSNSRSVAELVIAEIITL
ARQLGDRSIEMHAGTWNKVSAKCYEIRGKTLGIVGYGHIGSQLSVLAEAMGMTVIYYDVITIMPLGSAKQVPTLEALLRQ
ADFVTLHVPQLPETFKMISTAQFDVMKEGSYLINASRGNVVDIPALIAAKNSGKLAGAALDVYPNEPAKNGVGLFNDSLN
DWASSLCQLSNIILTPHIGGSTSEAQASISIEVSDKLSRYVNEGSTNGAVNFPEVSLRSSPSDDSDKARVLYVHQNVPGV
LKTVNEILSHHNIEKQYTESHGEIAYLMADVSNVSESGIKELYDQLEQTPFKITTRILY

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.