MCA_05114_1

Protein

Length

467 amino acids

Gene name: SER3

Description: 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase

Browser: contigD:386982-388386-

RNA-seq: read pairs 8713, FPKM 230.0, percentile rank 89.6% (100% = highest expression)

Protein function

Annotation:		SER3	3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase
KEGG:	K00058	serA	D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
EGGNOG:	0PFGT	FG07468.1	d-3-phosphoglycerate dehydrogenase
SGD closest match:	S000000883	SER3	D-3-phosphoglycerate dehydrogenase 1
CGD closest match:	CAL0000190003	SER33	Phosphoglycerate dehydrogenase

Protein alignments

	%id	Aln length
MIA_03831_1	80.77%	442	MIA_03831_1
A0A0J9XJ60_GEOCN	79.73%	439	Similar to Saccharomyces cerevisiae YER081W SER3 3-phosphoglycerate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA18s01418g PE=3 SV=1
UniRef50_A3LPQ2	78.07%	424	3-phosphoglycerate dehydrogenase, serine biosynthesis n=302 Tax=Fungi TaxID=4751 RepID=A3LPQ2_PICST
Q5A3K7_CANAL	76.87%	428	Phosphoglycerate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SER33 PE=3 SV=1
A0A161HNM6_9ASCO	75.57%	442	Phosphoglycerate dehydrogenase SER33 OS=Sugiyamaella lignohabitans GN=SER33 PE=3 SV=1
A0A1E3PFB8_9ASCO	74.31%	432	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28004 PE=3 SV=1
A0A060T4U0_BLAAD	74.54%	432	ARAD1C00550p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C00550g PE=3 SV=1
SERA_YEAST	73.82%	424	D-3-phosphoglycerate dehydrogenase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SER3 PE=1 SV=1
Q6C284_YARLI	72.85%	442	YALI0F09966p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09966g PE=4 SV=1
A0A1E4TFF9_9ASCO	72.31%	437	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31443 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6552
Predicted cleavage: 46

Protein family membership

None predicted.

Domains and repeats

Domain
59 - 379
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
153 - 348
NAD(P)-binding domain (IPR016040)
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)
397 - 467
ACT domain (IPR002912)

1 50 100 150 200 250 300 350 400 467

Detailed signature matches

IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  59 - 379
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  153 - 348
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  163 - 347
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR002912

ACT domain
1. PS51671 (ACT)
  
  397 - 467
  
  PROSITE profiles
  PS51671 (ACT)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  199 - 226
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)
IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
1. PS00671 (D_2_HYDROX...)
  
  274 - 290
  
  PROSITE patterns
  PS00671 (D_2_HYDROXYACID_DH_3)
2. PS00670 (D_2_HYDROX...)
  
  245 - 267
  
  PROSITE patterns
  PS00670 (D_2_HYDROXYACID_DH_2)

no IPR

Unintegrated signatures

G3DSA:3.30.70...

381 - 466

GENE3D
G3DSA:3.30.70.260 (G3DSA:3.30.70.260)
G3DSA:3.40.50...

183 - 348

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

8 - 182

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
SSF52283 (Formate/g...)

55 - 174

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
SSF55021 (ACT-like)

392 - 466

SUPERFAMILY
SSF55021 (ACT-like)
cd04901 (ACT_3PGDH)

397 - 466

CDD
cd04901 (ACT_3PGDH)
cd12176 (PGDH_3)

57 - 368

CDD
cd12176 (PGDH_3)
mobidb-lite (disord...)

1 - 34

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ligand binding sit...

105R

ligand binding site
105R, 106S, 128C, 129I, 130G, 153N
CDD
cd12176 (PGDH_3)

106S

ligand binding site
105R, 106S, 128C, 129I, 130G, 153N
CDD
cd12176 (PGDH_3)

128C

ligand binding site
105R, 106S, 128C, 129I, 130G, 153N
CDD
cd12176 (PGDH_3)

129I

ligand binding site
105R, 106S, 128C, 129I, 130G, 153N
CDD
cd12176 (PGDH_3)

130G

ligand binding site
105R, 106S, 128C, 129I, 130G, 153N
CDD
cd12176 (PGDH_3)

153N

ligand binding site
105R, 106S, 128C, 129I, 130G, 153N
CDD
cd12176 (PGDH_3)
NAD binding site c...

129I

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

151F

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

153N

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

157V

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

203G

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

204Y

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

205G

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

206H

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

207I

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

225Y

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

226D

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

227V

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

230I

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

255H

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

256V

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

257P

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

261E

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

262T

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

265M

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

283A

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

284S

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

285R

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

309D

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

345H

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

347G

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)

348G

NAD binding site
129I, 151F, 153N, 157V, 203G, 204Y, 205G, 206H, 207I, 225Y, 226D, 227V, 230I, 255H, 256V, 257P, 261E, 262T, 265M, 283A, 284S, 285R, 309D, 345H, 347G, 348G
CDD
cd12176 (PGDH_3)
tetramer interface...

155R

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

156S

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

159E

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

160L

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

162I

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

163A

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

164E

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

166I

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

167T

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

170R

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

172L

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

175R

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

176S

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

179M

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

180H

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

182G

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

184W

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

185N

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

186K

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

187V

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

188S

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

189S

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

190K

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

191C

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

192W

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

193E

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

194I

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

195R

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

197K

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

217S

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

218M

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

311Y

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

314E

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

315P

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

318N

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

329A

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

330W

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

334L

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

335C

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

337L

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

340I

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

341I

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

342L

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

343T

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

344P

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

345H

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

346I

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

347G

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

349S

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

350T

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

351E

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

352E

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)

354Q

tetramer interface
155R, 156S, 159E, 160L, 162I, 163A, 164E, 166I, 167T, 170R, 172L, 175R, 176S, 179M, 180H, 182G, 184W, 185N, 186K, 187V, 188S, 189S, 190K, 191C, 192W, 193E, 194I, 195R, 197K, 217S, 218M, 311Y, 314E, 315P, 318N, 329A, 330W, 334L, 335C, 337L, 340I, 341I, 342L, 343T, 344P, 345H, 346I, 347G, 349S, 350T, 351E, 352E, 354Q
CDD
cd12176 (PGDH_3)
catalytic site cd1...

285R

catalytic site
285R, 314E, 345H
CDD
cd12176 (PGDH_3)

314E

catalytic site
285R, 314E, 345H
CDD
cd12176 (PGDH_3)

345H

catalytic site
285R, 314E, 345H
CDD
cd12176 (PGDH_3)
L-serine binding s...

402H

L-serine binding site
402H, 404N, 420N
CDD
cd04901 (ACT_3PGDH)

404N

L-serine binding site
402H, 404N, 420N
CDD
cd04901 (ACT_3PGDH)

420N

L-serine binding site
402H, 404N, 420N
CDD
cd04901 (ACT_3PGDH)
ACT domain interfa...

404N

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

406P

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

409L

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

410K

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

413N

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

420N

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

422E

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

423K

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

424Q

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

425Y

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

426T

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

427E

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

428S

ACT domain interface
404N, 406P, 409L, 410K, 413N, 420N, 422E, 423K, 424Q, 425Y, 426T, 427E, 428S
CDD
cd04901 (ACT_3PGDH)

Protein sequence

>MCA_05114_1
MSAPKDIASVQSTSPSNAVSSSPPSTFMGSPSFGRRRLSYTGTREKKALKPFSTGDIKVLLLENVNQTGIDIFHEQGYQV
EFYKSSLPEEELIEKIKDVHVIGIRSKTMLTEKVLKAAQNLIAIGCFCIGTNQVNLDYAASRGIAVFNSPFSNSRSVAEL
VIAEIITLARQLGDRSIEMHAGTWNKVSSKCWEIRGKTLGIIGYGHIGSQLSVLAESMGMNVIYYDVINIMGMGTAKQVP
TLEALLKAADFVTLHVPQLPETKNMISTPQLNAMKDGSYLINASRGHVVDIPALVEARKSGKLAGAALDVYPNEPAKNGV
GIFNDSLNAWASELCQLGNIILTPHIGGSTEEAQSAIGIEVGAALVKYVNEGNSTGAVNFPEVSLRALTLEEADRARVLY
VHKNVPGVLKTVNEILSAHNVEKQYTESRGEIAYLMTDISGCSESDIKDLYNQLENTPFRITTRLLY

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component