Protein

MIA_03793_1

Length
370 amino acids

Browser: contig04:2175695-2177317-

Protein function

EGGNOG:0PFWGIDH2Isocitrate dehydrogenase
SGD closest match:S000005662IDH2Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial
CGD closest match:CAL0000183793IDH2Isocitrate dehydrogenase [NAD] subunit, mitochondrial

Protein alignments

%idAln lengthE-value
MCA_03653_190.270%3700.0MCA_03653_1
A0A0J9XJW9_GEOCN85.946%3700.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Geotrichum candidum GN=BN980_GECA24s00395g PE=3 SV=1
Q6CA33_YARLI81.792%3460.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06303g PE=3 SV=1
A0A060SXH8_BLAAD80.636%3460.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03718g PE=3 SV=1
A0A1D8PGS5_CANAL80.814%3440.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IDH2 PE=3 SV=1
A0A1E4TLK4_9ASCO79.480%3460.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30738 PE=3 SV=1
A0A1E3PUA7_9ASCO79.348%3680.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81394 PE=3 SV=1
A0A161HG75_9ASCO82.622%3280.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Sugiyamaella lignohabitans GN=IDH2 PE=3 SV=1
UniRef50_A0A161HG7582.622%3280.0Isocitrate dehydrogenase [NAD] subunit, mitochondrial n=10 Tax=Opisthokonta TaxID=33154 RepID=A0A161HG75_9ASCO
IDH2_YEAST67.529%3481.92e-166Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IDH2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9924
Predicted cleavage: 23

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 370

Detailed signature matches

  1. Family IPR004434
    Isocitrate dehydrogenase NAD-dependent
    1. TIGR00175
  2. Domain IPR024084
    Isopropylmalate dehydrogenase-like domain
    1. SM01329 (Iso_dh_2)
    2. PF00180 (Iso_dh)
  3. SITE IPR019818
    Isocitrate/isopropylmalate dehydrogenase, conserved site
    1. PS00470 (IDH_IMDH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.71...
  2. SSF53659 (Isocitrat...)

Protein sequence

>MIA_03793_1
MLASRTSFLRTAAQALRAQRTYATSVASFHGKKNANGNYTVTLIEGDGIGIEISAAVKEIYAAAKVPIEWEPVDVTPILV
DGKTTIPKPAVDSVKKNLVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSVIGYKTPYENVDTVLIRENTEGEYS
GIEHVVVPGVVQSIKLITKPASERVLRYAFEYAKSIGKTKVLVVHKASIMKVSDGLFLSTANELAAEYPDIELSTELIDS
TCLRLVTDPAPYKEYVMVMPNLYGDILSDLSSGLIGGLGLTPSGNMGDQVSIFEAVHGSAPDIAGKGLANPTALLLSSVM
MLRHMGLNDSANKIEKAVLETIASGPENRTGDLKGSASTKKFTEEVIKRL

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0055114 oxidation-reduction process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.