Protein

MIA_03781_1

Length
1,759 amino acids

Browser: contig04:2143676-2149009-

Protein function

EGGNOG:0PHNIPGUG_04190protein kinase Gcn2
SGD closest match:S000002691GCN2eIF-2-alpha kinase GCN2
CGD closest match:CAL0000185174GCN2Serine/threonine-protein kinase

Protein alignments

%idAln lengthE-value
A0A060TEN3_BLAAD44.397%9460.0ARAD1D16192p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D16192g PE=4 SV=1
UniRef50_A0A060TEN344.397%9460.0ARAD1D16192p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060TEN3_BLAAD
MCA_03833_153.138%7490.0MCA_03833_1
A0A0J9XC20_GEOCN49.391%7390.0Similar to Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation OS=Geotrichum candidum GN=BN980_GECA08s03926g PE=4 SV=1
A0A1E3PN66_9ASCO40.106%9450.0Serine/threonine-protein kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_56876 PE=4 SV=1
A0A167CD00_9ASCO44.216%7780.0Serine/threonine-protein kinase GCN2 OS=Sugiyamaella lignohabitans GN=GCN2 PE=4 SV=1
Q6CEK5_YARLI42.610%7512.04e-178YALI0B14949p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14949g PE=4 SV=2
GCN2_YEAST37.976%7618.50e-149eIF-2-alpha kinase GCN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCN2 PE=1 SV=3
A0A1E4TBX8_9ASCO36.100%7236.78e-129Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16753 PE=4 SV=1
A0A1D8PQT9_CANAL34.088%7071.02e-106Serine/threonine-protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GCN2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0296

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1600 1759

Detailed signature matches

  1. Family IPR016255
    eIF-2-alpha kinase Gcn2
    1. PIRSF000660 (STPK_GCN2)
  2. Domain IPR016135
    Ubiquitin-conjugating enzyme/RWD-like
    1. SSF54495 (UBC-like)
    2. G3DSA:3.10.11...
  3. Domain IPR006575
    RWD domain
    1. SM00591 (RWD2001b)
    2. PS50908 (RWD)
    3. PF05773 (RWD)
  4. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  5. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  6. Domain IPR024435
    Histidyl tRNA synthetase-related domain
    1. PF12745 (HGTP_antic...)
  7. Domain IPR004154
    Anticodon-binding
    1. G3DSA:3.40.50...
  8. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  9. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.51...
  3. G3DSA:3.30.20...
  4. G3DSA:3.30.93...
  5. PF13393 (tRNA-synt_His)
  6. SSF55681 (Class II ...)
  7. cd14012 (PK_eIF2AK_...)
  8. mobidb-lite (disord...)

Protein sequence

>MIA_03781_1
MKRYNKKEQEKYINEAQQDEFDSLAAIYGDDFHIVKNNASAWNKSLPAFVIDLRSQMGTDNMITVSVRVEFTITYPSTSP
VVTIKKYNGLATLQIKKLNAIVSDFFKDPNNRNREIVFDLLSLVQDTINDFEDSFKEGSLEEQRTQRIKEEQEKKKQEEK
AIARKKEQEEIRLNQEKNRLLEDEKKRRQQELEIKEATENAASAIKHPAPLKKNDDTVVTFDRMISVRANGSTIKFKQVY
GKIPTEVDFLGRHYLVKPVLDMAQSDGNISFMLTEIDLEEEYWTTAEGKKQVHLLEKDLEVIRQIHHENIVTLYESKISH
LGSGGWRIALLSEYSPFSRVSYLLDTVETVSIKVTRAWANQLLDGLEHLHKCGITHKLVNVDNIYLFRNSEIGETTVKLS
RPSYGYKLLDMNARHKFTSTNIVLPERKWNPPELNVKPIPLPTKKSDIYDFGTVVCQLLEGKNIVNKFKSPFTFLESPHT
FARYKGTDIFYDLKDFLVNSFNPTPKKRYSTVELLTSKFFRDFNTNSMSSISLSPVSTSQSMRFRRRSSNNQIQRGMSNA
NGPSQLFSRYQHDFIEFQLLGRGAYGEVVKARNKLDSQFYAIKKIQSTQSKLDGIIGEVWLLSRLNHQHIVRYITAWLEE
GPSIPSENAITDSEYEDDDEDEEPSSTLPSKANSIHTRSTAPSKSPSLLNVGGLRDLSLSTPLDFSNGGPEIVFGYSSGD
GSRSGSDDDSNDSEDSDESDSDDFDSDGSELSSEAIDSTEEAEDDTTEDDGSRVNCSTIEEEDEDDDTDMSRPKSNNVKR
HISHSRPSTANRLNKSLIPVSKPLPEINTLFIQMEYCENRTLADLIKDGLSSQPDEYWRLFRQIIDALNYIHVNGVIHRD
LKPVNIFIGHGNNVKIGDFGLAKSIGQSLVTSSSSVTTPETTEELTQEVGTSLYIAPEVLNGSGTYDSKVDMYSLGIIFF
EMVFPMSTAMERVSILRGIRDPKIICPFDFLAARYEREHTLVVKLLDHNPNQRPSAMQLQSSPLVPMPREDEATEKILMK
IRNAKGDSHLISQVCNALFSKELDTISAILYDSGLDEYRKSTSDYLLLSHLTEIISCIFRNHGAVPIDDRSIIFPSPAIY
EYGNLAKLMDRSGNILQLPYDLTYPFARKLAQAPINASKSYYFGSVYRERDEGSNKSLEPRKCNEISFDIVTHHTADSIF
NESEVIKVLDDIINVLPSFKRENVSIVLNHSDILDAILKFCSIPQQLRSPALLLFGQYGLQPPSSELKDMILSQHGLTSS
SITDLELFGFRNTLENAEATILKLLRDSDPGKLFREAIEHIREVIHYLRKMGVTRPIYLAPLSHYNPEFYKGGVMFQVVA
EVNKKDQPFNFLAGGGRYDSLIRSLRCQMGLDKGVACRAVGFNLSLDFLYGSMFAFREGLIRKQNKKNDRHLDINEQLSG
WVEPRCNVLVANFQATNNLDNCLEILKMLWDEGYRTDFIQNAGSSEGVFQVAEKEGIKFVVIVKQQASYVSSKNFKPIRI
ISISTPRTDLDVSKRELISKLNILFSARERVNLKTANNNSGNTSGNGNGNSSHIGGLHVRASSGTSNSQGSAIVGGGGTS
TGSNSSGLHHHHHHFHHMDSSEMAGSGGSEPHHGIELPQNQKITVLSEGKVKGGKKNQWKIEESAQNSATNLIREIGSAP
VYSLDVKDDVLDAILATSLDQAEEWRRKVVGLSPSQKAYLMETQTALSKEVARGTPYIILYSSKTARTVIYSVSQNWGF

GO term prediction

Biological Process

GO:0000077 DNA damage checkpoint
GO:0006468 protein phosphorylation
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

None predicted.