MCA_03833_1
Gene name: GCN2
Description: Protein kinase Gcn2; in S. cerevisiae phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation.
Browser: contigC:1219898-1225333+
RNA-seq: read pairs 1568, FPKM 10.8, percentile rank 27.3% (100% = highest expression)
Protein function
| Annotation: | GCN2 | Protein kinase Gcn2; in S. cerevisiae phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation. | |
|---|---|---|---|
| KEGG: | K16196 | EIF2AK4 | eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1] |
| EGGNOG: | 0PHNI | PGUG_04190 | protein kinase Gcn2 |
| SGD closest match: | S000002691 | GCN2 | eIF-2-alpha kinase GCN2 |
| CGD closest match: | CAL0000185174 | GCN2 | Serine/threonine-protein kinase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03781_1 | 50.31% | 958 | 0.0 | MIA_03781_1 |
| A0A0J9XC20_GEOCN | 43.57% | 918 | 0.0 | Similar to Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation OS=Geotrichum candidum GN=BN980_GECA08s03926g PE=4 SV=1 |
| UniRef50_A0A0J9XC20 | 43.57% | 918 | 0.0 | Similar to Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XC20_GEOCN |
| A0A060TEN3_BLAAD | 42.83% | 920 | 0.0 | ARAD1D16192p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D16192g PE=4 SV=1 |
| A0A167CD00_9ASCO | 41.62% | 961 | 0.0 | Serine/threonine-protein kinase GCN2 OS=Sugiyamaella lignohabitans GN=GCN2 PE=4 SV=1 |
| A0A1E3PN66_9ASCO | 39.60% | 909 | 0.0 | Serine/threonine-protein kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_56876 PE=4 SV=1 |
| Q6CEK5_YARLI | 37.83% | 920 | 0.0 | YALI0B14949p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14949g PE=4 SV=2 |
| GCN2_YEAST | 37.55% | 916 | 8e-166 | eIF-2-alpha kinase GCN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCN2 PE=1 SV=3 |
| A0A1E4TBX8_9ASCO | 33.15% | 899 | 2e-138 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16753 PE=4 SV=1 |
| A0A1D8PQT9_CANAL | 31.28% | 959 | 1e-126 | Serine/threonine-protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GCN2 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0678
Protein family membership
- eIF-2-alpha kinase Gcn2 (IPR016255)
Domains and repeats
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Domain
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Domain
Detailed signature matches
no IPR
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PF13393 (tRNA-synt_His)
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SSF55681 (Class II ...)
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cd14012 (PK_eIF2AK_...)
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mobidb-lite (disord...)
Protein sequence
>MCA_03833_1 MDSSTKLSDADIKSIQEEEIAAIEAIYGNDFHLVESKSNAWQRTTPAFIVTLIADGNTKLSASVKIEFTLTYPLSPPIVT IPTHSGLSFHQVQSIKNDIKNILSNKVYKGEIVAFVILDSVQESLYKFEAAYAKGSLEEQRLDRIAQEQQQQLEKQEALV QQREKEEIRLQEEQDTKISDELKRRQKVIEYKEATTGNKSLPISRPTSSHQNNSNSQEGYLPPDHVTFDRIVTINANGHS IKFNKVGGKIPVNVNFFGNHYIVKPIISDTTYLPTDSSSNDTNISLLLSEIDLEGEYWTSFSSKQEIHSLENELLKVMKI KHDNVLALYEANICRLKDGSWRITLLSEYSPIAGLGSMIDAIGTVNAKVAKNWATQILDGLNCIHSNGISHKLVDLDSVY LFQNPEVGESILKLAYPSYGYKLLEMNHHHNFQSPNSVNNANAYNKNKNKTRHRARSNSTSKGKNKESKLSNTLVKPQKW VPPELLKENISTPSRKTDIYDFGTLMSQLIEGRNIVSRFSSPKQYLESQDALVQYQGTPAYELLRDFLTKSFNPSPKSRF STVELLTSSFIISSIDTTFERSVPILSPKQPPARRLPTSAAVERRIYENDPLPTAPNLLRRPSSDHESVLSNGRSSSTAP AFSRYLHDFDFIQQLGKGGYGEVVKVRNKLDGQPYAIKMIHSSKFKLDKIVSEVWLLARLNHRYIVRYITAWVEEDFQSR ASELKGSQSSSDETSSEDEDESTSESKSFQIQVKPGTAAVNSISRQDSQVISTKEGLSLSTALDFSRSEKHVEITFGDSS SDDSYDDEDEDDEDDDDEDDEDDDDEDEDDDESNFTFGEDSCGDSTSFNPNDDDDDYNFVFENSLSKGKDDTPNDTTSTV DTTSKRAKSSETSVATRKSKRGKSVPKSTTLFIQMEYCENHTLSDLIHDGLCNQRDEYWRLLRQLLAALDYIHNNGIIHR DLKPVNIFIDEANNAKIGDFGLARRVGQSLISMNQPLEAGEEYTQEVGTSFYIAPEVLSSGQGVYDSKIDMYSLGIIFFE MVYPLPTAMERANVLKDIRLPQIKFPSKFLSPVYQREHDIVLQLLQHDPNKRPSAKQLQTSLLIPTPNEDELISEVLHKV TTGDTTLVNQICKGLYSQELDTIPALLYDRDHQERKTVNENLLLSQIQNTISEIFRHHGAVFSDDRSIIFPSPAIYEYGN IAKYIDKFGTILQLPYDLTFPFARKLAQAPVSFRKSYFFGSVYRESEENIHSSVEPVKCAEASFDIVDTNSAIDSNYSDA EVIKVLDEVVDRFPFFKKGKIFLVINHGHILDAVLNFCMIPPSRRMAALSLLGKNGIGPASAEVKNELLTGQILETSTLT ELEIFGFRGTIDDAVARIRRNMRDKDPGTKFHDAISSLKAIENYISLLGVKFPVYLAPLSHYNSEFYREGVMFQLMFSDK RHTEHFIAGGGRYDHLIRHLQSQMGLLKSVVHSKAVGFNLSLDIFYKSSLVFREGLIKKKKKKQSKDTSNLLWSESLFDV IVTSFHSSSRDLCLKILRLLWESGIKADFVYNPNSTEEIFSKAEQDGINFVIIVKQVLLSTSKNFNPIRIKTLPERNDVD VSLQDLIPTLSTLMPMKDKGKTTTYNTVSHHRTSSHSANMAISNGKTNIGFESDEYSRKMMDNLQPSPSSVTILPEKPIK GGKKNQWHREHEALKYSKAFMEQISRAPIYVLDVRDEILEAILSTALDQPEEWKRKVVGLSPNQKAYLMDTQVTLSKEVA RGTRYIMLSSSKTGKTVLYSISRNN
GO term prediction
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006468 protein phosphorylation
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Cellular Component
None predicted.