MIA_03749_1

Protein

Length

572 amino acids

Browser: contig04:2054954-2056673-

Protein function

EGGNOG:	0PGND	FG00176.1	Isocitrate lyase
SGD closest match:	S000006210	ICL2	Mitochondrial 2-methylisocitrate lyase
CGD closest match:	CAL0000178151	ICL1	Isocitrate lyase

Protein alignments

	%id	Aln length	E-value
MCA_03761_1	85.689%	573	0.0	MCA_03761_1
A0A0J9X5T4_GEOCN	73.951%	572	0.0	Isocitrate lyase OS=Geotrichum candidum GN=BN980_GECA03s07754g PE=3 SV=1
A0A167D5J1_9ASCO	71.128%	523	0.0	Isocitrate lyase OS=Sugiyamaella lignohabitans GN=ICL2 PE=3 SV=1
A0A060T6H2_BLAAD	69.558%	565	0.0	Isocitrate lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15796g PE=3 SV=1
ACEB_YARLI	65.091%	550	0.0	2-methylisocitrate lyase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0F31999g PE=1 SV=1
A0A1E4THM6_9ASCO	62.996%	554	0.0	Isocitrate lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2976 PE=3 SV=1
A0A1E3PFR2_9ASCO	68.219%	494	0.0	Isocitrate lyase and phosphorylmutase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47495 PE=4 SV=1
UniRef50_A0A0L1HVA1	60.311%	514	0.0	Isocitrate lyase n=1 Tax=Stemphylium lycopersici TaxID=183478 RepID=A0A0L1HVA1_9PLEO
ACEB_YEAST	53.107%	531	0.0	Mitochondrial 2-methylisocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICL2 PE=1 SV=1
Q59RB8_CANAL	44.972%	527	2.57e-152	Isocitrate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ICL1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9852
Predicted cleavage: 28

Protein family membership

Isocitrate lyase (IPR006254)

Domains and repeats

Domain
39 - 555
Pyruvate/Phosphoenolpyruvate kinase-like domain (IPR015813)

1 100 200 300 400 500 572

Detailed signature matches

IPR006254

Isocitrate lyase
1. PIRSF001362 (ICL)
  
  384 - 572
  
  PIRSF
  PIRSF001362 (ICL)
  
  40 - 316
  
  PIRSF
  PIRSF001362 (ICL)
2. PF00463 (ICL)
  
  49 - 572
  
  Pfam
  PF00463 (ICL)
3. TIGR01346
  
  49 - 572
  
  TIGRFAMs
  TIGR01346 (TIGR01346)
IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain
1. SSF51621 (Phosphoen...)
  
  39 - 555
  
  SUPERFAMILY
  SSF51621 (Phosphoenolpyruvate/pyruvate domain)
IPR018523

Isocitrate lyase/phosphorylmutase, conserved site
1. PS00161 (ISOCITRATE...)
  
  243 - 248
  
  PROSITE patterns
  PS00161 (ISOCITRATE_LYASE)

no IPR

Unintegrated signatures

G3DSA:3.20.20.60

41 - 556

GENE3D
G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
cd00377 (ICL_PEPM)

93 - 510

CDD
cd00377 (ICL_PEPM)

Residue annotation

tetramer interface...

95N

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

106P

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

108H

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

109T

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

110I

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

111G

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

113I

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

114D

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

115P

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

116V

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

117Q

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

119S

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

120Q

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

123K

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

125Q

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

126E

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

133W

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

137S

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

138V

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

146S

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

147P

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

150G

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

151D

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

152Y

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

153P

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

155D

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

156T

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

159N

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

160Q

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

162D

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

163R

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

166R

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

167A

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

213G

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

219M

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

220K

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

224L

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

227E

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

257S

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

258T

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

261S

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

264N

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

265A

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

268M

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

499T

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

500N

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

501G

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

503A

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

504T

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

505A

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

507L

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

508S

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)

509E

tetramer interface
95N, 106P, 108H, 109T, 110I, 111G, 113I, 114D, 115P, 116V, 117Q, 119S, 120Q, 123K, 125Q, 126E, 133W, 137S, 138V, 146S, 147P, 150G, 151D, 152Y, 153P, 155D, 156T, 159N, 160Q, 162D, 163R, 166R, 167A, 213G, 219M, 220K, 224L, 227E, 257S, 258T, 261S, 264N, 265A, 268M, 499T, 500N, 501G, 503A, 504T, 505A, 507L, 508S, 509E
CDD
cd00377 (ICL_PEPM)
active site cd00377

129Y

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

131S

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

132G

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

133W

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

148D

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

207D

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

209D

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

236E

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

282R

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

430E

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

458N

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

460S

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)

493S

active site
129Y, 131S, 132G, 133W, 148D, 207D, 209D, 236E, 282R, 430E, 458N, 460S, 493S
CDD
cd00377 (ICL_PEPM)
Mg2+/Mn2+ binding ...

148D

Mg2+/Mn2+ binding site
148D, 207D, 209D, 236E
CDD
cd00377 (ICL_PEPM)

207D

Mg2+/Mn2+ binding site
148D, 207D, 209D, 236E
CDD
cd00377 (ICL_PEPM)

209D

Mg2+/Mn2+ binding site
148D, 207D, 209D, 236E
CDD
cd00377 (ICL_PEPM)

236E

Mg2+/Mn2+ binding site
148D, 207D, 209D, 236E
CDD
cd00377 (ICL_PEPM)

Protein sequence

>MIA_03749_1
MLSSISKRSALSARINPRILMTSTAQLSTISKFPYPSADEEKAYYDKTVQEIKEWWASPRFKNITRPYPAEKVATFRGTL
PVSYPSSTQADKLFNLLTERSKQGAPVHTIGSIDPVQMSQSVKNQEIVYISGWACSSVLTTTNEVSPDFGDYPYDTVPNQ
VDRIFRAQQLHDRKSWHEWINLSEEERAKRTVEGKGRIDYLRPIIADGDTGHGGTGAVMKLAKLFAERGAAAVHLEDQLH
GGKKCGHLSGKVLVPTSTHISRLNATRMQWDIMGTSNLVIARTDSETGNLISSSVDPADHEFILGVNKPVKPLAQVLEEA
QGAGKSNEEIDALELEWTKNTPLMTFNDAVVAELKEAGKADQVDAYLAAAKGLSNFDARALAKKTLGKEVFFDWDAPRTR
EGYHAFKNGMDAAIKRAVAFGPFADLLWLETKKPNLEQAKAFAAEIHKHHPGKWLVYNLSPSFNWLGQGFSEKDLKDFVW
ELGKAGFTLQLISLAGIHTNGLATAQLSEGFKKDGMLAYVKNVQAKEKEIGIDLLTHQKWSGANFYDDMISTVVSGSSST
SSVGKDSTEHAF

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features