Protein

MIA_03749_1

Length
572 amino acids


Browser: contig04:2054954-2056673-

Protein function

EGGNOG:0PGNDFG00176.1Isocitrate lyase
SGD closest match:S000006210ICL2Mitochondrial 2-methylisocitrate lyase
CGD closest match:CAL0000178151ICL1Isocitrate lyase

Protein alignments

%idAln lengthE-value
MCA_03761_185.689%5730.0MCA_03761_1
A0A0J9X5T4_GEOCN73.951%5720.0Isocitrate lyase OS=Geotrichum candidum GN=BN980_GECA03s07754g PE=3 SV=1
A0A167D5J1_9ASCO71.128%5230.0Isocitrate lyase OS=Sugiyamaella lignohabitans GN=ICL2 PE=3 SV=1
A0A060T6H2_BLAAD69.558%5650.0Isocitrate lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15796g PE=3 SV=1
ACEB_YARLI65.091%5500.02-methylisocitrate lyase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0F31999g PE=1 SV=1
A0A1E4THM6_9ASCO62.996%5540.0Isocitrate lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2976 PE=3 SV=1
A0A1E3PFR2_9ASCO68.219%4940.0Isocitrate lyase and phosphorylmutase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47495 PE=4 SV=1
UniRef50_A0A0L1HVA160.311%5140.0Isocitrate lyase n=1 Tax=Stemphylium lycopersici TaxID=183478 RepID=A0A0L1HVA1_9PLEO
ACEB_YEAST53.107%5310.0Mitochondrial 2-methylisocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICL2 PE=1 SV=1
Q59RB8_CANAL44.972%5272.57e-152Isocitrate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ICL1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9852
Predicted cleavage: 28

Protein family membership

Domains and repeats

1 100 200 300 400 500 572

Detailed signature matches

    1. PF00463 (ICL)
    1. SSF51621 (Phosphoen...)
    1. PS00161 (ISOCITRATE...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00377 (ICL_PEPM)

Residue annotation

  1. tetramer interface...
  2. active site cd00377
  3. Mg2+/Mn2+ binding ...

Protein sequence

>MIA_03749_1
MLSSISKRSALSARINPRILMTSTAQLSTISKFPYPSADEEKAYYDKTVQEIKEWWASPRFKNITRPYPAEKVATFRGTL
PVSYPSSTQADKLFNLLTERSKQGAPVHTIGSIDPVQMSQSVKNQEIVYISGWACSSVLTTTNEVSPDFGDYPYDTVPNQ
VDRIFRAQQLHDRKSWHEWINLSEEERAKRTVEGKGRIDYLRPIIADGDTGHGGTGAVMKLAKLFAERGAAAVHLEDQLH
GGKKCGHLSGKVLVPTSTHISRLNATRMQWDIMGTSNLVIARTDSETGNLISSSVDPADHEFILGVNKPVKPLAQVLEEA
QGAGKSNEEIDALELEWTKNTPLMTFNDAVVAELKEAGKADQVDAYLAAAKGLSNFDARALAKKTLGKEVFFDWDAPRTR
EGYHAFKNGMDAAIKRAVAFGPFADLLWLETKKPNLEQAKAFAAEIHKHHPGKWLVYNLSPSFNWLGQGFSEKDLKDFVW
ELGKAGFTLQLISLAGIHTNGLATAQLSEGFKKDGMLAYVKNVQAKEKEIGIDLLTHQKWSGANFYDDMISTVVSGSSST
SSVGKDSTEHAF

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity

Cellular Component

None predicted.