MCA_03761_1

Protein

Length

571 amino acids

Gene name: ICL2

Description: Mitochondrial 2-methylisocitrate lyase

Browser: contigC:1004354-1006070-

RNA-seq: read pairs 1265, FPKM 27.3, percentile rank 50.1% (100% = highest expression)

Protein function

Annotation:		ICL2	Mitochondrial 2-methylisocitrate lyase
KEGG:	K01637	E4.1.3.1	isocitrate lyase [EC:4.1.3.1]
EGGNOG:	0PGND	FG00176.1	Isocitrate lyase
SGD closest match:	S000006210	ICL2	Mitochondrial 2-methylisocitrate lyase
CGD closest match:	CAL0000178151	ICL1	Isocitrate lyase

Protein alignments

	%id	Aln length	E-value
MIA_03749_1	85.69%	573	0.0	MIA_03749_1
A0A0J9X5T4_GEOCN	73.94%	564	0.0	Isocitrate lyase OS=Geotrichum candidum GN=BN980_GECA03s07754g PE=3 SV=1
A0A060T6H2_BLAAD	72.61%	544	0.0	Isocitrate lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15796g PE=3 SV=1
A0A167D5J1_9ASCO	69.83%	527	0.0	Isocitrate lyase OS=Sugiyamaella lignohabitans GN=ICL2 PE=3 SV=1
ACEB_YARLI	67.88%	551	0.0	2-methylisocitrate lyase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0F31999g PE=1 SV=1
A0A1E4THM6_9ASCO	62.82%	554	0.0	Isocitrate lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2976 PE=3 SV=1
A0A1E3PFR2_9ASCO	68.22%	494	0.0	Isocitrate lyase and phosphorylmutase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47495 PE=4 SV=1
UniRef50_A1CMM8	56.83%	542	0.0	Isocitrate lyase n=43 Tax=leotiomyceta TaxID=716546 RepID=A1CMM8_ASPCL
ACEB_YEAST	53.01%	515	0.0	Mitochondrial 2-methylisocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICL2 PE=1 SV=1
Q59RB8_CANAL	44.92%	541	1e-150	Isocitrate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ICL1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9772
Predicted cleavage: 20

Protein family membership

Isocitrate lyase (IPR006254)

Domains and repeats

Domain
38 - 554
Pyruvate/Phosphoenolpyruvate kinase-like domain (IPR015813)

1 100 200 300 400 500 571

Detailed signature matches

IPR006254

Isocitrate lyase
1. PIRSF001362 (ICL)
  
  377 - 571
  
  PIRSF
  PIRSF001362 (ICL)
  
  38 - 341
  
  PIRSF
  PIRSF001362 (ICL)
2. TIGR01346
  
  48 - 571
  
  TIGRFAMs
  TIGR01346 (TIGR01346)
3. PF00463 (ICL)
  
  48 - 571
  
  Pfam
  PF00463 (ICL)
IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain
1. SSF51621 (Phosphoen...)
  
  38 - 554
  
  SUPERFAMILY
  SSF51621 (Phosphoenolpyruvate/pyruvate domain)
IPR018523

Isocitrate lyase/phosphorylmutase, conserved site
1. PS00161 (ISOCITRATE...)
  
  242 - 247
  
  PROSITE patterns
  PS00161 (ISOCITRATE_LYASE)

no IPR

Unintegrated signatures

G3DSA:3.20.20.60

40 - 555

GENE3D
G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
cd00377 (ICL_PEPM)

92 - 509

CDD
cd00377 (ICL_PEPM)

Residue annotation

tetramer interface...

94N

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

105P

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

107H

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

108T

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

109I

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

110G

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

112V

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

113D

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

114P

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

115V

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

116Q

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

118S

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

119Q

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

122K

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

124Q

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

125E

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

132W

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

136S

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

137L

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

145S

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

146P

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

149G

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

150D

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

151Y

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

152P

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

154D

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

155T

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

158N

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

159Q

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

161D

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

162R

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

165R

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

166A

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

212G

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

218M

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

219K

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

223L

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

226E

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

256S

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

257T

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

260S

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

263N

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

264A

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

267M

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

498T

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

499N

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

500G

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

502A

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

503T

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

504A

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

506L

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

507S

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)

508E

tetramer interface
94N, 105P, 107H, 108T, 109I, 110G, 112V, 113D, 114P, 115V, 116Q, 118S, 119Q, 122K, 124Q, 125E, 132W, 136S, 137L, 145S, 146P, 149G, 150D, 151Y, 152P, 154D, 155T, 158N, 159Q, 161D, 162R, 165R, 166A, 212G, 218M, 219K, 223L, 226E, 256S, 257T, 260S, 263N, 264A, 267M, 498T, 499N, 500G, 502A, 503T, 504A, 506L, 507S, 508E
CDD
cd00377 (ICL_PEPM)
active site cd00377

128Y

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

130S

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

131G

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

132W

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

147D

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

206D

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

208D

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

235E

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

281R

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

429E

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

457N

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

459S

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)

492S

active site
128Y, 130S, 131G, 132W, 147D, 206D, 208D, 235E, 281R, 429E, 457N, 459S, 492S
CDD
cd00377 (ICL_PEPM)
Mg2+/Mn2+ binding ...

147D

Mg2+/Mn2+ binding site
147D, 206D, 208D, 235E
CDD
cd00377 (ICL_PEPM)

206D

Mg2+/Mn2+ binding site
147D, 206D, 208D, 235E
CDD
cd00377 (ICL_PEPM)

208D

Mg2+/Mn2+ binding site
147D, 206D, 208D, 235E
CDD
cd00377 (ICL_PEPM)

235E

Mg2+/Mn2+ binding site
147D, 206D, 208D, 235E
CDD
cd00377 (ICL_PEPM)

Protein sequence

>MCA_03761_1
MLHHFSKRTSALSARLPRIVSMTSSFSTISKFPYPSAEEEQKYFDNTVKEIKEWWASPRFKNITRPYPAEKVASFRGTLP
VSYPSSVQADKLFNLLSERSSKGEPVHTIGSVDPVQMSQSVKNQEIVYISGWACSSLLTTTNEVSPDFGDYPYDTVPNQV
DRIFRAQQLHDRKAWHEWVNLSPEQRAKLAAEGKGRIDYMRPIIADGDTGHGGTGAVMKLAKLFAERGAAAVHFEDQLHG
GKKCGHLAGKVLVPTSTHISRLNAARMQWDIMGTNNLLIARTDSETGNLISSSVDPSDHEYILGVNKPVKPLAQVLEEAQ
ARGASNEEIDRLEIEWTENTPLLTFNEAVVEELKAAGKSDLIESYLKEASGLSNFDARQLAKSKLGKEVFFDWDAPRSRE
GYHPFKNGIDAAVKRANAFGSYADLLWLETKKPNLQQAKDFAKRIHEKHPGKWLVYNLSPSFNWLGQGFSEQDLKDFVWE
LGKAGFTLQLISLAGLHTNGLATAQLSEGFKKDGMLAYVKNVQAKEKELNLDLLTHQKWSGANFYDDMISTVVSGSSSTS
SVGKDSTENAF

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features