Protein

MIA_03738_1

Length
513 amino acids

Browser: contig04:2026500-2028219+

Protein function

EGGNOG:0PG0MPGUG_02515ENTH domain-containing protein
SGD closest match:S000001204YAP1801Clathrin coat assembly protein AP180A
CGD closest match:CAL0000184462orf19.4184Uncharacterized protein

Protein alignments

%idAln lengthE-value
MCA_05999_160.837%4066.59e-156MCA_05999_1
A0A0J9XHE7_GEOCN67.797%2953.80e-135Similar to Saccharomyces cerevisiae YHR161C YAP1801 Protein involved in clathrin cage assembly OS=Geotrichum candidum GN=BN980_GECA14s03233g PE=4 SV=1
UniRef50_A0A0J9XHE767.797%2957.78e-132Similar to Saccharomyces cerevisiae YHR161C YAP1801 Protein involved in clathrin cage assembly n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHE7_GEOCN
A0A1E3PEB8_9ASCO59.044%2932.18e-116ANTH-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48050 PE=4 SV=1
A0A060TBP8_BLAAD55.254%2952.45e-106ARAD1B10164p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B10164g PE=4 SV=1
A0A1D8PL36_CANAL52.632%3045.40e-96Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4184 PE=4 SV=1
Q6CF76_YARLI47.697%3045.43e-87YALI0B09603p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B09603g PE=4 SV=1
A0A167E4S4_9ASCO58.974%2342.52e-85Yap1801p OS=Sugiyamaella lignohabitans GN=YAP1801 PE=4 SV=1
A0A1E4TD15_9ASCO46.599%2943.19e-78Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148580 PE=4 SV=1
AP18A_YEAST38.321%2742.91e-50Clathrin coat assembly protein AP180A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YAP1801 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3040

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 513

Detailed signature matches

  1. Domain IPR008942
    ENTH/VHS
    1. SSF48464 (ENTH/VHS ...)
    2. G3DSA:1.25.40.90
  2. Domain IPR013809
    ENTH domain
    1. PS50942 (ENTH)
    2. SM00273 (enth_2)
  3. Domain IPR011417
    AP180 N-terminal homology (ANTH) domain
    1. PF07651 (ANTH)
  4. Domain IPR014712
    Phosphoinositide-binding clathrin adaptor, domain 2
    1. G3DSA:1.20.58...
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF89009 (GAT-like ...)
  2. cd03564 (ANTH_AP180...)
  3. mobidb-lite (disord...)

Residue annotation

  1. PtdIns(4,5)P2-bind...

Protein sequence

>MIA_03738_1
MRYDKIVKGATKIKLAAPKAKYVEPILEATGNRDDLNAVLSLLGQRMADTAWTVSYKALVVVHIMIREGARDATLAALSH
QAHIFDRVSGSGHSYNINRYARYLRERVVQYSNTHVDYVRARSRSSDRDRDRSSSASGGRLRSLTVDKGLLRECDSVLDQ
IGALLKCRFHENDVDNDIVLTAFRFLVRDLLSLYQVLNEGVINVLEHYFEMSKIDATHGLDIYKRFTKQTNDVVNFLRVA
KLLEYQTKLHVPNIKHAPVSLTQSLEDYLSDPNFETNHRQYMAEKQAREASGFGTNQPSPQSRGSSSSGQNSTAGAVSRR
KSYVSRSQSLRQQPTANGSSAAIDSTNPFRAMLQQQQTANISGPPVAQPQDPNVVAVFQGNIQVPENQIPSRIVIQPTIH
KRKHKRKHKRKHKRKHKRKHKRKHKRKHKRKHKRKHKRKHKRKHKRKHKRKHKRKHKHKHKHRRKHKRKHKHKHKHKRKH
KHKHKHKHKHKHKHKRKLRFNNFKPNTQLNNKP

GO term prediction

Biological Process

GO:0048268 clathrin coat assembly

Molecular Function

GO:0005543 phospholipid binding
GO:0005545 1-phosphatidylinositol binding
GO:0030276 clathrin binding

Cellular Component

GO:0030136 clathrin-coated vesicle