Protein

MCA_05999_1

Length
729 amino acids

Browser: contigD:2993903-2996269-

RNA-seq: read pairs 3191, FPKM 54.0, percentile rank 66.9% (100% = highest expression)

Protein function

KEGG:K20044PICALM phosphatidylinositol-binding clathrin assembly protein
EGGNOG:0PG0MPGUG_02515ENTH domain-containing protein
SGD closest match:S000001204YAP1801Clathrin coat assembly protein AP180A
CGD closest match:CAL0000184462orf19.4184Uncharacterized protein

Protein alignments

%idAln lengthE-value
MIA_03738_161.58%4068e-143MIA_03738_1
A0A0J9X6D0_GEOCN56.91%3763e-135Similar to Saccharomyces cerevisiae YHR161C YAP1801 Protein involved in clathrin cage assembly OS=Geotrichum candidum GN=BN980_GECA03s06445g PE=4 SV=1
UniRef50_A0A0J9XHE757.82%3774e-130Similar to Saccharomyces cerevisiae YHR161C YAP1801 Protein involved in clathrin cage assembly n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHE7_GEOCN
A0A1E3PEB8_9ASCO57.63%2627e-102ANTH-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48050 PE=4 SV=1
A0A060TBP8_BLAAD59.07%2591e-99ARAD1B10164p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B10164g PE=4 SV=1
A0A167E4S4_9ASCO66.67%2226e-96Yap1801p OS=Sugiyamaella lignohabitans GN=YAP1801 PE=4 SV=1
A0A1D8PL36_CANAL55.23%2772e-89Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4184 PE=4 SV=1
Q6CF76_YARLI49.26%2722e-80YALI0B09603p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B09603g PE=4 SV=1
A0A1E4TD15_9ASCO43.90%2465e-69Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148580 PE=4 SV=1
AP18A_YEAST36.61%2541e-46Clathrin coat assembly protein AP180A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YAP1801 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1112

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 729

Detailed signature matches

  1. Domain IPR008942
    ENTH/VHS
    1. SSF48464 (ENTH/VHS ...)
    2. G3DSA:1.25.40.90
  2. Domain IPR013809
    ENTH domain
    1. PS50942 (ENTH)
    2. SM00273 (enth_2)
  3. Domain IPR000261
    EH domain
    1. PS50031 (EH)
  4. Domain IPR011417
    AP180 N-terminal homology (ANTH) domain
    1. PF07651 (ANTH)
  5. Domain IPR014712
    Phosphoinositide-binding clathrin adaptor, domain 2
    1. G3DSA:1.20.58...
  6. Domain IPR015943
    WD40/YVTN repeat-like-containing domain
    1. G3DSA:2.130.1...
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. SSF89009 (GAT-like ...)
  3. cd03564 (ANTH_AP180...)
  4. mobidb-lite (disord...)

Residue annotation

  1. PtdIns(4,5)P2-bind...

Protein sequence

>MCA_05999_1
MASGRYDKIVKGATKVKVAAPKAKYVEPILDATNYPEDVESIIWSLSNRLKDPSWSISYKALIVIHIMIREGARDTTLDA
LGRHLHIFDYVSGNGRTHNISRYSRYLRERAAQFSKTHVDYVRSKSKNGSRLRNLSVDKGLLRECDSVLAQINALLKCKF
QEGDVDNDIVLTAFRFLVRDLLSLYQVLNEGVINVLEHYFEMTKVDAEHGLEIYKRFTKQTNEVVGFLRVAKMLEYQTKL
HVPNIKHAPVSLTQSLEDYLNDPDFEINHRQYLAEKQARDASGFGKKEPSPETKSSSKSTSGAFSTRQQQTNEQQKQASD
DTNPFKSLVQQQQQQQSQQQQQQQQQQPQVQVQLQQDPNLANIFNGSIQMQESVIPSGIIIQPNFVPVPAQQTQPFGNSQ
AVDWSNQAQIQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQ
ALQSQNTSQQPLSTMFTGAGFGGYSTSSSAILPNQNTAYTTASGTPSTLASTISSTPTPLSMQSTTSSGLSYSTEANPFR
SSMLPGQTTGNPFLKRNNTVSTPNGAFATGGVSVQRSASNPFSTAAPNTNPIPAMNTSQTHLASNPSTSYTSLPLNQQTT
GINPFRQSMTGQQQPLQYQPTMGGLENLATIPIFPQTQAHQQQQLQQLQQQQQQQQQFMLQQQMTNQQQMQGQQQQPIMF
TGAPQQTLI

GO term prediction

Biological Process

GO:0048268 clathrin coat assembly

Molecular Function

GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005545 1-phosphatidylinositol binding
GO:0030276 clathrin binding

Cellular Component

GO:0030136 clathrin-coated vesicle