Protein

MIA_03722_1

Length
419 amino acids

Browser: contig04:1974964-1976224+

Protein function

EGGNOG:0QDVDEND3Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)
SGD closest match:S000005028END3Actin cytoskeleton-regulatory complex protein END3
CGD closest match:CAL0000174035END3Actin cytoskeleton-regulatory complex protein END3

Protein alignments

%idAln lengthE-value
MCA_04824_170.843%4390.0MCA_04824_1
A0A060T292_BLAAD57.314%4176.25e-168ARAD1C29370p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29370g PE=4 SV=1
A0A167DBU4_9ASCO59.524%4201.11e-165End3p OS=Sugiyamaella lignohabitans GN=END3 PE=4 SV=1
A0A0J9X531_GEOCN61.005%4184.88e-165Similar to Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis OS=Geotrichum candidum GN=BN980_GECA02s07655g PE=4 SV=1
END3_YARLI52.998%4172.69e-151Actin cytoskeleton-regulatory complex protein END3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=END3 PE=3 SV=1
A0A1E3PMN6_9ASCO54.306%4184.97e-147Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51356 PE=4 SV=1
A0A1E4T9U1_9ASCO47.733%4195.27e-123Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_124246 PE=4 SV=1
UniRef50_Q6BY7747.255%4191.88e-117Actin cytoskeleton-regulatory complex protein END3 n=26 Tax=Saccharomycetales TaxID=4892 RepID=END3_DEBHA
END3_CANAL42.654%4222.99e-110Actin cytoskeleton-regulatory complex protein END3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=END3 PE=2 SV=1
END3_YEAST38.889%2526.60e-44Actin cytoskeleton-regulatory complex protein END3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=END3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0112

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 419

Detailed signature matches

  1. Family IPR025604
    Actin cytoskeleton-regulatory complex protein End3
    1. PF12761 (End3)
  2. Domain IPR011992
    EF-hand domain pair
    1. SSF47473 (EF-hand)
  3. Domain IPR000261
    EH domain
    1. SM00027 (eh_3)
    2. PF12763 (EF-hand_4)
    3. PS50031 (EH)
  4. Domain IPR002048
    EF-hand domain
    1. PS50222 (EF_HAND_2)
    2. SM00054 (efh_1)
  5. SITE IPR018247
    EF-Hand 1, calcium-binding site
    1. PS00018 (EF_HAND_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.23...
  3. cd00052 (EH)
  4. mobidb-lite (disord...)

Residue annotation

  1. pseudo EF-hand loo...
  2. peptide binding po...
  3. Ca2+ binding site ...

Protein sequence

>MIA_03722_1
MPQIEQWEVQKYWEIFSGLKPTPAGLLSGDKVATVFKNSQLSEDKLAKIWDLADVDQDGNLDFEEFCIAMRIIYDIVNGV
YSDPPETLPQWLVPQSKSYLVEANQAISGNGPPPSSSRRSSSNSYDEDEDLSLSSDFDWYISPSQRNEYSAIYTANADYH
GLISFDALTELYQTLDNIPRTDISSAWNLVNPRSNEKIDKEQCIVFLHILSTRSKGFRIPRSVPASLRATFEKSAPEYSL
NSSQSIVRRGNSDDQDYSSSSSNNKKSFANDYLTRLGLGGRAKSGIDNAQGTDFSSTRDTDWEEVRLKRQLADLEDLIKK
AEAATERRKRGIEDFNSSKTGLVKRELEQLLAYKEKQLLSLRNGSLKSGSSANDSENRALQDSQEEIDLLTIQIDSLKQH
HTKRLHELETLRQQVEAAR

GO term prediction

Biological Process

GO:0006897 endocytosis
GO:0007015 actin filament organization

Molecular Function

GO:0005509 calcium ion binding
GO:0005515 protein binding

Cellular Component

None predicted.