Protein

MIA_03720_1

Length
620 amino acids

Browser: contig04:1968860-1971280-

Protein function

EGGNOG:0PH6VVMA1vacuolar atp synthase catalytic subunit a
SGD closest match:S000002344VMA1V-type proton ATPase catalytic subunit A
CGD closest match:CAL0000187512TFP1V-type proton ATPase catalytic subunit A

Protein alignments

%idAln lengthE-value
MCA_04826_289.968%6180.0MCA_04826_2
UniRef50_Q5AJB182.553%6190.0V-type proton ATPase catalytic subunit A n=342 Tax=Eukaryota TaxID=2759 RepID=VATA_CANAL
VATA_CANAL82.553%6190.0V-type proton ATPase catalytic subunit A OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TFP1 PE=1 SV=2
A0A1E3PJX0_9ASCO82.068%6190.0Vacuolar ATP synthase catalytic subunit A OS=Nadsonia fulvescens var. elongata DSM 6958 GN=VMA1 PE=3 SV=1
A0A167DBW4_9ASCO84.974%5790.0H(+)-transporting V1 sector ATPase subunit A OS=Sugiyamaella lignohabitans GN=VMA1 PE=3 SV=1
Q6CHD8_YARLI80.261%6130.0YALI0A09900p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A09900g PE=3 SV=1
A0A060T2N6_BLAAD81.174%5790.0ARAD1C29436p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29436g PE=3 SV=1
A0A0J9X536_GEOCN85.841%3390.0Similar to Saccharomyces cerevisiae YDL185W VMA1 Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase OS=Geotrichum candidum GN=BN980_GECA02s07754g PE=4 SV=1
VATA_YEAST78.371%3560.0V-type proton ATPase catalytic subunit A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VMA1 PE=1 SV=3
A0A1E4TBF3_9ASCO77.119%3540.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_53321 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1688

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 620

Detailed signature matches

  1. Family IPR022878
    V-type ATP synthase catalytic alpha chain
    1. MF_00309 (ATP_synth...)
  2. Family IPR005725
    ATPase, V1 complex, subunit A
    1. TIGR01042
  3. Domain IPR004100
    ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
    1. SSF50615 (N-termina...)
    2. PF02874 (ATP-synt_ab_N)
  4. Domain IPR031686
    ATPsynthase alpha/beta subunit, N-terminal extension
    1. PF16886 (ATP-synt_a...)
  5. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  6. Domain IPR000194
    ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
    1. PF00006 (ATP-synt_ab)
  7. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  8. Domain IPR024034
    ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
    1. G3DSA:1.10.11...
  9. SITE IPR020003
    ATPase, alpha/beta subunit, nucleotide-binding domain, active site
    1. PS00152 (ATPASE_ALP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SSF47917 (C-termina...)
  3. cd01134 (V_A-ATPase_A)

Residue annotation

  1. Walker A motif/ATP...
  2. Walker B motif cd0...

Protein sequence

>MIA_03720_1
MRVAGAIENARKELKNLNIDDIAESQYGSIYSVSGPVVVAENMIGSAMYELVKVGHDNLVGEVIRIDGDKCTIQVYEETA
GVTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIQEKSQSIYIPRGIDAPALSRTVKYDFTAAPGLKVGDHVTGGD
ILGSVFENSLMSSHHILLPPKGKGTITYIAAPGSYTVDEKIVEVEFAGTKYEYSMFHTWPVREPRPVANKLTANYPLLTG
QRVLDALFPVVQGGTTCIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMAEVLMEFPELFTVVEGRKEPIMKRTT
LVANTSNMPVAAREASIYTGITIAEYFRDQGKNVAMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAG
KATALGSPDREGSVSIVAAVSPPGGDFSDPVTMSTLSITQVFWGLDKKLAQRKHFPSVNTSVSYSKYTNVLNKYYESSYP
EFPSLRDKVKGILSNAEELEQVVQLVGKSALSDSDKITLDVSSLIKDDFLQQNGYSTYDAFCPIWKTNAMLKAFVTYFEE
AQKAVSTGAPWARIAEATADVKHSVSSAKFFEPSRGEEELKVEFDKLQNDIVEKFANAAE

GO term prediction

Biological Process

GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0046034 ATP metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0046961 proton-transporting ATPase activity, rotational mechanism

Cellular Component

GO:0033180 proton-transporting V-type ATPase, V1 domain