Protein

MIA_03718_1

Length
1,717 amino acids


Browser: contig04:1962166-1967372+

Protein function

EGGNOG:0PG8VTOP2Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity)
SGD closest match:S000005032TOP2DNA topoisomerase 2
CGD closest match:CAL0000175071TOP2DNA topoisomerase 2

Protein alignments

%idAln lengthE-value
MCA_03577_180.463%11670.0MCA_03577_1
A0A0J9X495_GEOCN73.464%11720.0DNA topoisomerase 2 OS=Geotrichum candidum GN=BN980_GECA02s07776g PE=3 SV=1
A0A060TAB6_BLAAD67.119%11800.0DNA topoisomerase 2 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D22572g PE=3 SV=1
A0A1E3PNV1_9ASCO66.778%11980.0DNA topoisomerase 2 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21822 PE=3 SV=1
UniRef50_W1Q6Y463.425%12030.0DNA topoisomerase 2 n=8 Tax=Dikarya TaxID=451864 RepID=W1Q6Y4_OGAPD
Q6C7Z9_YARLI61.661%11920.0DNA topoisomerase 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23969g PE=3 SV=1
A0A1D8PMM1_CANAL61.686%11980.0DNA topoisomerase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TOP2 PE=3 SV=1
TOP2_YEAST61.304%11810.0DNA topoisomerase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP2 PE=1 SV=2
A0A1E4TJ76_9ASCO59.231%11970.0DNA topoisomerase 2 OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30135 PE=3 SV=1
A0A167CGU8_9ASCO66.699%10300.0DNA topoisomerase 2 OS=Sugiyamaella lignohabitans GN=TOP2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0180

Protein family membership

Domains and repeats

Detailed signature matches

    1. PR00418 (TPI2FAMILY)
    2. SM00433 (topII5)
    1. PR01158 (TOPISMRASEII)
    1. PF02518 (HATPase_c)
    2. SSF55874 (ATPase do...)
    1. SSF54211 (Ribosomal...)
    1. PF00204 (DNA_gyraseB)
    1. SSF56719 (Type II D...)
    1. PF01751 (Toprim)
    2. PS50880 (TOPRIM)
    1. cd03365 (TOPRIM_Top...)
    1. PF16898 (TOPRIM_C)
    1. SM00434 (topIV4)
    2. PF00521 (DNA_topoisoIV)
    1. PS00177 (TOPOISOMER...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00075 (HATPase_c)
  2. cd00187 (TOP4c)
  3. cd03481 (TopoIIA_Tr...)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075
  4. dimer interface cd...
  5. ATP binding cd03481
  6. putative metal-bin...
  7. active site cd03365
  8. CAP-like domain cd...
  9. Active site cd00187
  10. primary dimer inte...

Protein sequence

>MIA_03718_1
MGYFSESDDGGPSLKFTTTRRRGVKSKSYVVSDEDDDMGNFVDNFSDDDDSDFGVTSAKPTSSGSSKAKKTNSVTKPTAA
PKPPRAKKAAAKPLVETSANEISSEESKSILDHFPQEANDKENKPADGSTPKSKKDASSQYQKLTQLEHILKRPDTYIGS
VEPTEMKLWVFDPVSKDMEFKDVTIVPGLYKIFDEILVNAADNKIRDPSMNLLEVNIDADTNTISIYNGGKGIPIEIHKK
EKIYIPELIFGNLLTSSNYDDNEKKVTGGRNGYGAKLCNIFSTEFTVETADKSTNQVYKQTWTKNMSQVGKPQITKNTKH
QEYTKITFKPDLSLFHMEKIDNDLLGVLYRRVYDVAGCMTECKVLLNHVRLHIKNFKSYTEMFVKALEKTAKENSVPGED
AEANKSPVIVYEKINDRWEVAFAVSDGSFNQVSFVNSIATTSGGTHVNYIADQIVNKITEQIKKAKIPIKNFQVKNNMFL
FVNCLIENPAFTSQTKEQLTTRATAFGSKCVLPPEFLKKVLKTPILDRVRDIATRNADNQIRKTDGGKTRRIKGMAKLED
ANKAGTREGYKCTLVLTEGDSAMALAVAGLAVVGRDYYGVFPLRGKLLNVREASHDQIMKNTEIQSIKQIMGLQHKKQYT
STKELRYGHIMIMTDQDHDGSHIKGLIINFLESTFPGLLEIPGFLVEFITPIVKVSILRGKKVVEVIPFYTMPEYESWRE
TTGKECTWKKKYYKGLGTSDPTEGREYFSRLDKHLKTFHELEAEDKPLIELAFSKKKADERKDWLRQFRPGTHLDPDLDN
IPISEFINKELILFSIADNMRSIPSVMDGLKPGQRKVMYGCFKRNLVNEIKVAQLAGYISEHTGYHHGEPSLVSTIVNLA
QNFVGSNNLYLLMPKGSFGSRAAGGKDSSAPRYIHTELNPITKSIFHPADESIYNYLEDDEATVEPEWYAPVIPMILVNG
SEGIGTGWSTNIPPFNPEDIVTNIRHLMNGEEMDPLIPWYRGWTGTVERLPDNKFRASGIVNQISDTELEITELPPHTWT
INMRDFLLNQLRDKRDNKAGWIEDFTEDHGLGVKFNITLTPEEMEKTLKVGPLNRFKLTSPINLNNMVAFDPQNRIKKYS
SPEEMINDFYYVRLECYQKRKNFWSNLLKNQLIKLTQQARFVKMIIDKEFVVTNRKKADIIEDLQKHKFPSFGKDGTPNY
SQISDDDSLDENEIPDDVEDPRKNKPSYDYLLGMAIWSLTRERYERLLNERDNKETELNILLGKTPKDLWNEDLDVFLEK
WEVFLEEDREQRESLIPNKKRGKGKGKGKTTRKAPAKSKRKRDDSDGEDDDDDDDDDFVVSTKKKKTGGDTKAAPAKRAT
RTKKPTATSTLDGFITKLEEEEEGDKKDITKTATSNNTSSTTSGSLKHTSEFDKSPEDLFSALSSFSPGSKTKEPKKKET
SDADTKPKRRVLSKAPSATPAKSSFISNILDDSDDDIFSFSSVKKSVKPKKEEISSPVKAESPKPTVVKSSANPGTKSAG
SGRANSRQLSADIIEDSDEDANYDLNNEMKEREEERKREELKEEEVKPKKRAAPKSRKKAASPIFMIEEDKDSDIEMEEE
KPAPKKRGSTKAVTKPAAKSVRKKADVSDVEDLPAPKTNAKTKGATAAKSRKKKDEDDEVVGLDLDSMADDQQEKEEVVG
RSRSSRRARGAAPKRYAFDSDEGGEDDDDDMFVVEDD

GO term prediction

Biological Process

GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005524 ATP binding

Cellular Component

None predicted.