Protein
MIA_03554_1
Length
990 amino acids
Browser: contig04:1529305-1532331+
Protein function
| EGGNOG: | 0PFGE | ADE3 | C-1-tetrahydrofolate synthase |
|---|---|---|---|
| SGD closest match: | S000000288 | MIS1 | C-1-tetrahydrofolate synthase, mitochondrial |
| CGD closest match: | CAL0000181460 | MIS11 | Trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9YH90_GEOCN | 83.929% | 952 | 0.0 | Similar to Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase OS=Geotrichum candidum GN=BN980_GECA01s00912g PE=3 SV=1 |
| MCA_03201_1 | 79.897% | 975 | 0.0 | MCA_03201_1 |
| A0A1E3PST5_9ASCO | 76.165% | 944 | 0.0 | C1-THFS protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_30651 PE=3 SV=1 |
| A0A167DXR6_9ASCO | 73.069% | 984 | 0.0 | Trifunctional formate-tetrahydrofolate ligase OS=Sugiyamaella lignohabitans GN=MIS1 PE=3 SV=1 |
| A0A060T747_BLAAD | 73.502% | 951 | 0.0 | ARAD1C25828p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25828g PE=3 SV=1 |
| Q6BZU8_YARLI | 73.361% | 961 | 0.0 | YALI0F30745p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F30745g PE=3 SV=1 |
| A0A1E4TJX2_9ASCO | 72.175% | 938 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_603 PE=3 SV=1 |
| UniRef50_A0A1V8U155 | 70.701% | 942 | 0.0 | C-1-tetrahydrofolate synthase, cytoplasmic n=1 Tax=Rachicladosporium sp. CCFEE 5018 TaxID=1974281 RepID=A0A1V8U155_9PEZI |
| Q59SM8_CANAL | 70.148% | 948 | 0.0 | Trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MIS11 PE=3 SV=1 |
| C1TM_YEAST | 67.055% | 944 | 0.0 | C-1-tetrahydrofolate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MIS1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9257
Predicted cleavage: 49
Protein family membership
- Tetrahydrofolate dehydrogenase/cyclohydrolase (IPR000672)
- Formate-tetrahydrofolate ligase, FTHFS (IPR000559)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
900
990
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
homodimer interfac...
-
NADP binding site ...
-
substrate binding ...
-
Cesium cation bind...
-
Potassium binding ...
Protein sequence
>MIA_03554_1 MFSSSLRSLRAVRAERVVPKLRHLAATKSSVPLVFSAMRSFSHAARLLDAEKIDGKAIAKLIREEVHTEIDSLKASTPSF KPNLVIIQVGSRPDSSAYVRMKLKAAKEADILCEHINLPEDITETQLLHRIEKLNDDPSVHGVLVQLPLPKSINETTITN AVVTEKDVDGFGPINVGELAKRGGSPLFVPCTPKGVMVLLERSGVDIRGKRAVVVGRSDIVGNPASYLLRNADATVTVCH SRTQNLPDVIREADIVVAAIGKPEFVKGDWIKPGAVVIDVGINYIPDATKKSGKRLVGDVEYTSAAKVASKITPVPGGVG PMTVAMLIKNVLDSAKRSLDVESHRHITPLPLELKSPVPSDIAISRAQEPKHVRTVAKEIGITEHEFEPYGAYKGKVSLD VLDRLNDRVDGKYVLVAGITPTPLGEGKSTTTVGLVQALGAHLNKMAFATVRQPSMGPTFGIKGGAAGGGYSQVIPMDEF NMHLTGDIHAISAANNLLAAAIDTRMFHENSQKDAALYKRLVPVKNGVRKFTPSMLRRLKKLGIDKTDPNSLTPEEITKF ARLDIDPDTITWRRVVDCNDRMLRTITIGEGKAEKGQTRVTGFDISVASECMAILALSSSLKDMRERLGHMVVASNKQGE PVTCEDIGAGGALTALLKDAIKPNLMQTLEGTPVFVHAGPFANISIGASSILADKIALKLAGTHEGEDRKEKAGYVVTEA GFDFTMGGERFFNIKCRTSGLRPDAVVIVATVRALKLHGGGPDVKPGASLPEVYRTENVELVKNGARSNLRKQIENAKSY GSPVVVAINRFVTDTDAELEAIREAALEAGAFDAVPTNHWEQGGLGAIDLAQAVIKATDSPKATEKINLLYSTDGTSPEE KLNIIAQKMYGAAGVELSEVAKKKIETYTKQGFGNLPICIAKTQYSLSHDPALKGAPTGFTVPIRDLRASVGGGYLYALA AEIMTIPGLPTHAGFMNVEVNEDGEIEGLF
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0003824 catalytic activity
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
Cellular Component
None predicted.