Protein

MIA_03551_1

Length
1,020 amino acids

Browser: contig04:1519346-1522520-

Protein function

EGGNOG:0PFCBSPT5The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre- mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene
SGD closest match:S000004470SPT5Transcription elongation factor SPT5
CGD closest match:CAL0000192268SPT5Transcription elongation factor SPT5

Protein alignments

%idAln lengthE-value
MCA_03786_164.873%9850.0MCA_03786_1
A0A0J9X8U8_GEOCN57.719%9910.0Transcription elongation factor SPT5 OS=Geotrichum candidum GN=BN980_GECA05s04311g PE=3 SV=1
A0A1E3PPX9_9ASCO54.695%8520.0Transcription elongation factor SPT5 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49922 PE=3 SV=1
A0A060SW29_BLAAD54.670%8780.0Transcription elongation factor SPT5 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A01848g PE=3 SV=1
SPT5_YARLI50.422%9480.0Transcription elongation factor SPT5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SPT5 PE=3 SV=1
UniRef50_Q6CC8450.422%9480.0Transcription elongation factor SPT5 n=6 Tax=Saccharomycetales TaxID=4892 RepID=SPT5_YARLI
A0A1E4TG98_9ASCO43.861%9530.0Transcription elongation factor SPT5 OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57216 PE=3 SV=1
A0A167DDF8_9ASCO54.323%5327.18e-171Transcription elongation factor SPT5 OS=Sugiyamaella lignohabitans GN=SPT5 PE=4 SV=1
SPT5_CANAL41.919%7611.09e-161Transcription elongation factor SPT5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPT5 PE=3 SV=1
SPT5_YEAST37.300%8742.44e-150Transcription elongation factor SPT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPT5 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0033

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 1020

Detailed signature matches

  1. Family IPR017071
    Transcription elongation factor Spt5
    1. PIRSF036945 (Spt5)
  2. Domain IPR022581
    Spt5 transcription elongation factor, N-terminal
    1. PF11942 (Spt5_N)
  3. Domain IPR006645
    NusG, N-terminal
    1. SM00738 (nusgn_4)
    2. G3DSA:3.30.70...
  4. Domain IPR005100
    Transcription elongation factor Spt5, NGN domain
    1. PF03439 (Spt5-NGN)
  5. Domain IPR005824
    KOW
    1. SM00739 (kow_9)
    2. PF00467 (KOW)
  6. Domain IPR014722
    Ribosomal protein L2 domain 2
    1. G3DSA:2.30.30.30
  7. Domain IPR008991
    Translation protein SH3-like domain
    1. SSF50104 (Translati...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. PF12815 (CTD)
  3. cd06081 (KOW_Spt5_1)
  4. cd06082 (KOW_Spt5_2)
  5. cd06083 (KOW_Spt5_3)
  6. cd06084 (KOW_Spt5_4)
  7. cd06085 (KOW_Spt5_5)
  8. cd09888 (NGN_Euk)
  9. mobidb-lite (disord...)

Residue annotation

  1. heterodimer interf...

Protein sequence

>MIA_03551_1
MPRDDEQDNYDGDGEVQETSKNNKRTYSDGEEENEIRDYVNEEDEEEEEEEEEEEEEVGHSRRKRPRREARNQFLDVEAE
VDEDEEDYEEDDEGLLREDGFIQEDDHADYDEVSATDDRLHREVDRRREAIVEEDAEKLASEYKEKYGRSTASKYRGDTG
NVPQHLLLPSVQDPNIWGIRCKPGKERELVRMILKKKINLQNTKNPLEIFSVFQRDGFMGYIYIEARKVTAVDHALKGLV
NVYGASKILVPIKEYTDLLRVNKSKEQELTPGTYVRIKRGKYQGDLAIVENLSENGLEARLKVVPRLDYGRTAALNADGK
KRPNINSAKHRPPPRLFSELDATQFDRKNMAKRGLKSYVYHNETYEDGFLIKDYKLTYLTTENVMPTLEELQRFNGANEE
GIDLSTLSQTLKNDRSHVSFQTGDNIELFTGEQAGVQGRVLSIQGDIVTLKATSGLLTGQSFDAPASNLRKRFQIGEHVR
VASGNYSGAMGMVVDISKDNVTIVSDDSKNEITVFSRDLQDVSDIGSNSNATEDYELLNLVQLNAQSVGCIIRVDRGTLS
VLTQEGAVKTVPASSIIMKIGNKRQFATDRDGQEIRVGDTVKEMYGEGRTGVILHIHRRFLFLQDRNTTENLGVFVASIN
SVTTVAVKGARVDVNKRNEFGQQQSHNSSNSFSRGNNHNGHGQRNGSGVPIKQGGRDRVIGKAVTIGAGSQYKGFKGIVK
DATEDTARVELHARNKVVTVNKQQLLFTDAHGKTVSYTDFVVPAKLRHLAQPSRGGEQGGWAGGRTPAWNAGGGGRTPGW
ADGGRTPAAAGGRTPGYRAGGMTPNWNGSKTLSWGGSGSGHKTPAYGESGRYSSWGGNNDGGRTPAWNTGSRTPGYGGGS
RSSNWDSGSRTPAAGNSGAMSTWDASSSMNSNSRSGDYGNDRARSWYDSSKGNGSHGSHGSGHGGADMTAPTPGASAATP
HFAETPGAFSAPTPGVFQNDFDTAPTPGVFDAKTPGAAPTPAAWGSAHDAETPRFEPGTP

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0032784 regulation of DNA-templated transcription, elongation

Molecular Function

None predicted.

Cellular Component

None predicted.