Protein

MCA_03786_1

Length
994 amino acids


Gene name: SPT5

Description: Transcription elongation factor SPT5

Browser: contigC:1079163-1082273+

RNA-seq: read pairs 3579, FPKM 44.4, percentile rank 62.7% (100% = highest expression)

Protein function

Annotation:SPT5Transcription elongation factor SPT5
KEGG:K15172SUPT5H transcription elongation factor SPT5
EGGNOG:0PFCBSPT5The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre- mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene
SGD closest match:S000004470SPT5Transcription elongation factor SPT5
CGD closest match:CAL0000192268SPT5Transcription elongation factor SPT5

Protein alignments

%idAln lengthE-value
MIA_03551_164.72%9440.0MIA_03551_1
A0A0J9X8U8_GEOCN63.65%9050.0Transcription elongation factor SPT5 OS=Geotrichum candidum GN=BN980_GECA05s04311g PE=3 SV=1
A0A1E3PPX9_9ASCO54.41%9300.0Transcription elongation factor SPT5 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49922 PE=3 SV=1
A0A060SW29_BLAAD61.53%7720.0Transcription elongation factor SPT5 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A01848g PE=3 SV=1
SPT5_YARLI50.45%8800.0Transcription elongation factor SPT5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SPT5 PE=3 SV=1
UniRef50_Q6CC8450.45%8800.0Transcription elongation factor SPT5 n=6 Tax=Saccharomycetales TaxID=4892 RepID=SPT5_YARLI
A0A1E4TG98_9ASCO47.84%7880.0Transcription elongation factor SPT5 OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57216 PE=3 SV=1
A0A167DDF8_9ASCO56.57%5254e-174Transcription elongation factor SPT5 OS=Sugiyamaella lignohabitans GN=SPT5 PE=4 SV=1
SPT5_CANAL43.39%6731e-154Transcription elongation factor SPT5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPT5 PE=3 SV=1
SPT5_YEAST41.49%7111e-145Transcription elongation factor SPT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPT5 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0108

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 994

Detailed signature matches

    1. PF11942 (Spt5_N)
    1. SM00738 (nusgn_4)
    1. PF03439 (Spt5-NGN)
    1. SM00739 (kow_9)
    2. PF00467 (KOW)
    1. SSF50104 (Translati...)
    1. SM01104 (CTD_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF12815 (CTD)
  2. cd06081 (KOW_Spt5_1)
  3. cd06082 (KOW_Spt5_2)
  4. cd06083 (KOW_Spt5_3)
  5. cd06084 (KOW_Spt5_4)
  6. cd06085 (KOW_Spt5_5)
  7. cd09888 (NGN_Euk)
  8. mobidb-lite (disord...)

Residue annotation

  1. heterodimer interf...

Protein sequence

>MCA_03786_1
MVSEDDYDSDLENSSKTQVKQERKRVLDDEELEEENDFPNEEEEEEEEEEEEEEEDERHSRKRRRKELRNQFLDVEAEVD
DDEEDFDDDEDGLLKEDGFIQEDHIEEEDVARVDERLHREVDRRREAIVEEDAEKLASEYREKYGRSTASKYRGDTGVVP
QRLLLPSVQDPNIWGVRCKPGKEKELVRLILKKKMNLQHTNTPLEIYSAFQRDGFMGYIYIEARKVSAVEFALKGFANVY
FQNKILVPIKEYTDLLRVNKSKEQELTPGTYVRIKRGKYQGDLAIVENLSENGLEARLKVVPRLDYGKSAALNGENKRRP
NANSAKNRPAPRLFSELDAVQNDQQYLVKRGPKSFIYHNEQYEDGFLIKDYKLSYLITENVMPTLEELQRFNNASEEGID
LTSLSQTLKQDRNNATFQNGDHIQVVSGEQAGVTGRVISTQGDIVTVKASSGPLNGQVFDLPAANLRKKFMLGDHVRVVS
GNYSGETGMIVHVEKDSVIILSDLSKTEVTVFARDLKEASDIGGANIIGEYELLDLVQLNAETVGCIIKIDRDSVGVLTQ
DGDIRNVSPSSINMKIAGANRSFATDKDGNEIRVGDTVKEMHGKGRPGVILYIHRRYLFLQDRNSSMENLGVFVATINNV
TTIAVKGARVDTNKRGNANPNGGPGGNNRWGQGGQRNGPVPIKQGGRDRIIGQFVTIGRGSQYKGLKGIVKDTTDDTARI
ELDSRGKMVTVDKTKLLFKGPNGQSISYTEFVVPRRLLHLAQPGGGRGPNDRRGWNGDGGRTPAWGSSGGHGGRTPGWAD
GGRTPSMRGGRTPGWRPENTPNWNGSKTPAYGDGGRTPAWNAASRTPGWNAGSRTPGYGSSGNSGRSSTWDTGARTPGRM
STWDANSSAQAANSSSSSSSRDYGSSDNRSRSWYDSKTPAPMSDMTAPTPGAASAPTPGFPATPGAFSAPTPGGFQNDGY
DTAPTPGVYDAKTPGAAPTPAPWNSSMDSETPGY

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0032784 regulation of DNA-templated transcription, elongation

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.