Protein
MCA_03786_1
Length
994 amino acids
Gene name: SPT5
Description: Transcription elongation factor SPT5
Browser: contigC:1079163-1082273+
RNA-seq: read pairs 3579, FPKM 44.4, percentile rank 62.7% (100% = highest expression)
Protein function
| Annotation: | SPT5 | Transcription elongation factor SPT5 | |
|---|---|---|---|
| KEGG: | K15172 | SUPT5H | transcription elongation factor SPT5 |
| EGGNOG: | 0PFCB | SPT5 | The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre- mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene |
| SGD closest match: | S000004470 | SPT5 | Transcription elongation factor SPT5 |
| CGD closest match: | CAL0000192268 | SPT5 | Transcription elongation factor SPT5 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03551_1 | 64.72% | 944 | 0.0 | MIA_03551_1 |
| A0A0J9X8U8_GEOCN | 63.65% | 905 | 0.0 | Transcription elongation factor SPT5 OS=Geotrichum candidum GN=BN980_GECA05s04311g PE=3 SV=1 |
| A0A1E3PPX9_9ASCO | 54.41% | 930 | 0.0 | Transcription elongation factor SPT5 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49922 PE=3 SV=1 |
| A0A060SW29_BLAAD | 61.53% | 772 | 0.0 | Transcription elongation factor SPT5 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A01848g PE=3 SV=1 |
| SPT5_YARLI | 50.45% | 880 | 0.0 | Transcription elongation factor SPT5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SPT5 PE=3 SV=1 |
| UniRef50_Q6CC84 | 50.45% | 880 | 0.0 | Transcription elongation factor SPT5 n=6 Tax=Saccharomycetales TaxID=4892 RepID=SPT5_YARLI |
| A0A1E4TG98_9ASCO | 47.84% | 788 | 0.0 | Transcription elongation factor SPT5 OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57216 PE=3 SV=1 |
| A0A167DDF8_9ASCO | 56.57% | 525 | 4e-174 | Transcription elongation factor SPT5 OS=Sugiyamaella lignohabitans GN=SPT5 PE=4 SV=1 |
| SPT5_CANAL | 43.39% | 673 | 1e-154 | Transcription elongation factor SPT5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPT5 PE=3 SV=1 |
| SPT5_YEAST | 41.49% | 711 | 1e-145 | Transcription elongation factor SPT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPT5 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0108
Protein family membership
- Transcription elongation factor Spt5 (IPR017071)
Domains and repeats
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Domain
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Domain
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Domain
1
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994
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
heterodimer interf...
Protein sequence
>MCA_03786_1 MVSEDDYDSDLENSSKTQVKQERKRVLDDEELEEENDFPNEEEEEEEEEEEEEEEDERHSRKRRRKELRNQFLDVEAEVD DDEEDFDDDEDGLLKEDGFIQEDHIEEEDVARVDERLHREVDRRREAIVEEDAEKLASEYREKYGRSTASKYRGDTGVVP QRLLLPSVQDPNIWGVRCKPGKEKELVRLILKKKMNLQHTNTPLEIYSAFQRDGFMGYIYIEARKVSAVEFALKGFANVY FQNKILVPIKEYTDLLRVNKSKEQELTPGTYVRIKRGKYQGDLAIVENLSENGLEARLKVVPRLDYGKSAALNGENKRRP NANSAKNRPAPRLFSELDAVQNDQQYLVKRGPKSFIYHNEQYEDGFLIKDYKLSYLITENVMPTLEELQRFNNASEEGID LTSLSQTLKQDRNNATFQNGDHIQVVSGEQAGVTGRVISTQGDIVTVKASSGPLNGQVFDLPAANLRKKFMLGDHVRVVS GNYSGETGMIVHVEKDSVIILSDLSKTEVTVFARDLKEASDIGGANIIGEYELLDLVQLNAETVGCIIKIDRDSVGVLTQ DGDIRNVSPSSINMKIAGANRSFATDKDGNEIRVGDTVKEMHGKGRPGVILYIHRRYLFLQDRNSSMENLGVFVATINNV TTIAVKGARVDTNKRGNANPNGGPGGNNRWGQGGQRNGPVPIKQGGRDRIIGQFVTIGRGSQYKGLKGIVKDTTDDTARI ELDSRGKMVTVDKTKLLFKGPNGQSISYTEFVVPRRLLHLAQPGGGRGPNDRRGWNGDGGRTPAWGSSGGHGGRTPGWAD GGRTPSMRGGRTPGWRPENTPNWNGSKTPAYGDGGRTPAWNAASRTPGWNAGSRTPGYGSSGNSGRSSTWDTGARTPGRM STWDANSSAQAANSSSSSSSRDYGSSDNRSRSWYDSKTPAPMSDMTAPTPGAASAPTPGFPATPGAFSAPTPGGFQNDGY DTAPTPGVYDAKTPGAAPTPAPWNSSMDSETPGY
GO term prediction
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0032784 regulation of DNA-templated transcription, elongation
Molecular Function
GO:0005515 protein binding
Cellular Component
None predicted.