Protein

MIA_03522_1

Length
873 amino acids

Browser: contig04:1433522-1436197+

Protein function

EGGNOG:0PFZAMCM2DNA replication licensing factor Mcm2
SGD closest match:S000000119MCM2DNA replication licensing factor MCM2
CGD closest match:CAL0000193282MCM2DNA helicase

Protein alignments

%idAln lengthE-value
MCA_03984_172.623%8730.0MCA_03984_1
A0A0J9X2X0_GEOCN64.302%8740.0DNA helicase OS=Geotrichum candidum GN=BN980_GECA01s11318g PE=3 SV=1
A0A1E3PHH0_9ASCO62.485%8130.0DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_71360 PE=3 SV=1
A0A161HFQ0_9ASCO63.041%8090.0DNA helicase OS=Sugiyamaella lignohabitans GN=MCM2 PE=3 SV=1
A0A060T2A2_BLAAD62.000%8000.0DNA helicase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29700g PE=3 SV=1
MCM2_YEAST58.229%8810.0DNA replication licensing factor MCM2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCM2 PE=1 SV=2
UniRef50_P2946958.229%8810.0DNA replication licensing factor MCM2 n=250 Tax=Fungi TaxID=4751 RepID=MCM2_YEAST
Q5A034_CANAL60.591%8120.0DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MCM2 PE=3 SV=1
A0A1E4TKG4_9ASCO59.925%8010.0DNA helicase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_84151 PE=3 SV=1
Q6C2W1_YARLI57.036%8030.0DNA helicase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04664g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0754
Predicted cleavage: 11

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 873

Detailed signature matches

  1. Family IPR008045
    DNA replication licensing factor Mcm2
    1. PF12619 (MCM2_N)
    2. PR01658 (MCMPROTEIN2)
  2. Family IPR031327
    Mini-chromosome maintenance protein
    1. SM00350 (mcm)
  3. Domain IPR027925
    MCM N-terminal domain
    1. PF14551 (MCM_N)
  4. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  5. Domain IPR033762
    MCM OB domain
    1. PF17207 (MCM_OB)
  6. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  7. Domain IPR001208
    MCM domain
    1. PS50051 (MCM_2)
    2. PF00493 (MCM)
    3. PR01657 (MCMFAMILY)
  8. SITE IPR018525
    Mini-chromosome maintenance, conserved site
    1. PS00847 (MCM_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:1.10.8.300
  4. G3DSA:2.40.50...
  5. G3DSA:3.30.16...
  6. G3DSA:3.40.50...
  7. NON_CYTOPLASM... (N...)
  8. TRANSMEMBRANE (Tran...)
  9. cd00009 (AAA)
  10. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...
  3. Walker B motif cd0...
  4. arginine finger cd...

Protein sequence

>MIA_03522_1
MPSSLRRKRSDSIDSNESNGDNDVRRLPPSSPQGHYPPSSPPAAFFDDSENREDEIRDEDDIDELEELAEEVEGEDLYGD
NMYKDYQARDDDNYDLNDEQIDDANYEDDPEARRKAEQQLEYRDRLLQRTRQGLPDAFVPMEEEEKDLYGGTLPTTRRHR
YRYEDDGTDGLDEEGLTPQLISLEAIADVKANTVAEWISIPIVNNSIARELRKFLVELTDENNESVYGSRIRTLGEQNSE
SLEVDYNHLMESRATLAIFLSLAPAEMLRIFDVVAMGVVLIQYPQYASIHSEIHVRITGLREVLTLRDLREAHINKLVRV
TGVVTRRTGVFPQLKYVKFNCVKCNTVLGPFVQDSNSEVKVSFCHSCSSRGPFVLNSEKTLYRNFQKITLQESPGTVPAG
RLPRHRDVILLWDLIDSAKPGEEVDIIGIYKNSYDGSLNAKNGFPVFSTVIEANSVKRRDAGRVGEFNLSGEEERRIHNL
SKQRGIIDKIITSMAPSIYGHRDIKTAIACSLFGGVSKNVGNKHSIRGDINVLLLGDPGTAKSQFLKYAEKTSHRAVFAT
GQGASAVGLTASVRKDPITREWTLEGGALVLADKGTCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCAII
AAANPNGGRYNATLPFSQNVDLTEPILSRFDILCVVRDMVNPEIDEQLASFVLDSHMTAHPDGDDDDYDDEEEDEDDIAK
AKDKAMEENETTQPSQRSASTGTGLSQDSINPKSKYAEVQENAIPQDILCKYIYYARTRVTPMMYNNSYEDKLKDLYAAL
RRESIATGSYPITVRHFESIIRIAEAFARMELRDFITEYHIERAIKVTTQSFIGAQKLSVRRSLQQSFAKYTL

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006270 DNA replication initiation

Molecular Function

GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0005524 ATP binding

Cellular Component

GO:0005634 nucleus
GO:0042555 MCM complex