MCA_03984_1

Protein

Length

854 amino acids

Gene name: MCM2

Description: DNA replication licensing factor MCM2; component of the Mcm2-7 hexameric helicase complex

Browser: contigC:1697671-1700307-

RNA-seq: read pairs 1133, FPKM 16.4, percentile rank 36.0% (100% = highest expression)

Protein function

Annotation:		MCM2	DNA replication licensing factor MCM2; component of the Mcm2-7 hexameric helicase complex
KEGG:	K02540	MCM2	DNA replication licensing factor MCM2 [EC:3.6.4.12]
EGGNOG:	0PFZA	MCM2	DNA replication licensing factor Mcm2
SGD closest match:	S000000119	MCM2	DNA replication licensing factor MCM2
CGD closest match:	CAL0000193282	MCM2	DNA helicase

Protein alignments

	%id	Aln length
MIA_03522_1	72.31%	874	MIA_03522_1
A0A0J9X2X0_GEOCN	65.39%	864	DNA helicase OS=Geotrichum candidum GN=BN980_GECA01s11318g PE=3 SV=1
A0A161HFQ0_9ASCO	63.82%	854	DNA helicase OS=Sugiyamaella lignohabitans GN=MCM2 PE=3 SV=1
A0A1E3PHH0_9ASCO	66.67%	738	DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_71360 PE=3 SV=1
A0A060T2A2_BLAAD	63.62%	789	DNA helicase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29700g PE=3 SV=1
MCM2_YEAST	59.16%	862	DNA replication licensing factor MCM2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCM2 PE=1 SV=2
UniRef50_P29469	59.16%	862	DNA replication licensing factor MCM2 n=250 Tax=Fungi TaxID=4751 RepID=MCM2_YEAST
Q5A034_CANAL	65.34%	704	DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MCM2 PE=3 SV=1
A0A1E4TKG4_9ASCO	60.73%	797	DNA helicase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_84151 PE=3 SV=1
Q6C2W1_YARLI	57.43%	801	DNA helicase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04664g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0044

Protein family membership

DNA replication licensing factor Mcm2 (IPR008045)

Mini-chromosome maintenance protein (IPR031327)

Domains and repeats

Domain
201 - 288
MCM N-terminal domain (IPR027925)
297 - 423
MCM OB domain (IPR033762)
465 - 833
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
MCM domain (IPR001208)
Domain
205 - 444
Nucleic acid-binding, OB-fold (IPR012340)

1 100 200 300 400 500 600 700 800 854

Detailed signature matches

IPR008045

DNA replication licensing factor Mcm2
1. PR01658 (MCMPROTEIN2)
  
  329 - 341
  
  PRINTS
  PR01658 (MCMPROTEIN2)
  
  364 - 378
  
  PRINTS
  PR01658 (MCMPROTEIN2)
  
  440 - 451
  
  PRINTS
  PR01658 (MCMPROTEIN2)
  
  425 - 436
  
  PRINTS
  PR01658 (MCMPROTEIN2)
  
  306 - 323
  
  PRINTS
  PR01658 (MCMPROTEIN2)
2. PF12619 (MCM2_N)
  
  44 - 185
  
  Pfam
  PF12619 (MCM2_N)
IPR031327

Mini-chromosome maintenance protein
1. SM00350 (mcm)
  
  293 - 834
  
  SMART
  SM00350 (mcm)
IPR027925

MCM N-terminal domain
1. PF14551 (MCM_N)
  
  201 - 288
  
  Pfam
  PF14551 (MCM_N)
IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  205 - 444
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR033762

MCM OB domain
1. PF17207 (MCM_OB)
  
  297 - 423
  
  Pfam
  PF17207 (MCM_OB)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  487 - 688
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  735 - 833
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR001208

MCM domain
1. PS50051 (MCM_2)
  
  477 - 683
  
  PROSITE profiles
  PS50051 (MCM_2)
2. PF00493 (MCM)
  
  465 - 833
  
  Pfam
  PF00493 (MCM)
3. PR01657 (MCMFAMILY)
  
  657 - 665
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  578 - 592
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  518 - 533
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  606 - 619
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  630 - 642
  
  PRINTS
  PR01657 (MCMFAMILY)
IPR018525

Mini-chromosome maintenance, conserved site
1. PS00847 (MCM_1)
  
  586 - 594
  
  PROSITE patterns
  PS00847 (MCM_1)

no IPR

Unintegrated signatures

Coil

46 - 66

COILS
Coil (Coil)

854 - 854

COILS
Coil (Coil)
G3DSA:2.40.50...

295 - 451

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
G3DSA:3.30.16...

182 - 294

GENE3D
G3DSA:3.30.1640.10 (G3DSA:3.30.1640.10)
G3DSA:3.40.50...

461 - 694

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd00009 (AAA)

522 - 668

CDD
cd00009 (AAA)
mobidb-lite (disord...)

1 - 49

MobiDB Lite
mobidb-lite (disorder_prediction)

129 - 149

MobiDB Lite
mobidb-lite (disorder_prediction)

690 - 733

MobiDB Lite
mobidb-lite (disorder_prediction)

80 - 103

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Walker A motif cd0...

527G

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)

528D

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)

529P

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)

530G

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)

531T

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)

532A

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)

533K

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)

534S

Walker A motif
527G, 528D, 529P, 530G, 531T, 532A, 533K, 534S
CDD
cd00009 (AAA)
ATP binding site c...

528D

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

529P

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

530G

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

531T

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

532A

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

533K

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

534S

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

535Q

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

591D

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)

635N

ATP binding site
528D, 529P, 530G, 531T, 532A, 533K, 534S, 535Q, 591D, 635N
CDD
cd00009 (AAA)
Walker B motif cd0...

587T

Walker B motif
587T, 588C, 589L, 590I, 591D, 592E
CDD
cd00009 (AAA)

588C

Walker B motif
587T, 588C, 589L, 590I, 591D, 592E
CDD
cd00009 (AAA)

589L

Walker B motif
587T, 588C, 589L, 590I, 591D, 592E
CDD
cd00009 (AAA)

590I

Walker B motif
587T, 588C, 589L, 590I, 591D, 592E
CDD
cd00009 (AAA)

591D

Walker B motif
587T, 588C, 589L, 590I, 591D, 592E
CDD
cd00009 (AAA)

592E

Walker B motif
587T, 588C, 589L, 590I, 591D, 592E
CDD
cd00009 (AAA)
arginine finger cd...

660R

arginine finger
660R
CDD
cd00009 (AAA)

Protein sequence

>MCA_03984_1
MSSNRRKRSNPEDSDDEDNRLPPSSPERNVNFLSSPPMNFDDTEERDEIREDIEDLDEMAEEADGEDLFDDNMYRDYTNK
ADDNYDLNDEQIDDADYEDDVEARQRADRELNLRDRLLRNQRGLPDAFLADDEENFGSSPRNAPTRQRYRNTYDEFATDN
ENLDSDPFNKHMTLEELADVKADSVAEWIAIPSVQQSIARELRLFLTEYSDENGLTVYGSRIRTLGEINSESLEVNYNHL
MESKATIAYFLVVAPTEILRIFDLIAMEVVQIYYPYYASIHSEIHVRITDLPTPSTLRDLRESHINKLIRVTGVVTRRTG
VFPQLKYVKFDCLKCGTVLGPFAQDSNVEVKVSFCHNCQSRGPFALNSEKTLYRNFQKITLQESPGTVPAGRLPRHRDVI
LLWDLIDSAKPGEEIDVTGIYKNSYDGNLNAKNGFPVFLTIIEAVTVRRRDADLVGEFSLSEEEERQIQSLSKQKNIIDR
IITSMAPSIYGHRDIKTALACSLFGGVSKNVANKHSIRGDINVLLLGDPGTAKSQFLKYAEKTSHRAVFATGQGASAVGL
TASVRKDPITREWTLEGGALVLADKGTCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCAIIAAANPNGGR
YNATIPFSQNVDLTEPILSRFDILCVVRDMVNPEIDEQLARFVLDSHVSAHPDKTPLENDDDMDDEDSDTEGESPIGERN
RATRAPRPKESKIVSSYTKVQEDAIPQDLLRKYIYYARTRVTPKRYNNVGEDKISNLYVTLRRESIATGSYPITVRHFES
IIRISEAFARMELRDFISESHTERAIKVVVASFIGAQKLSAKKSLQRSFAKYMI

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006270 DNA replication initiation

Molecular Function

GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0005524 ATP binding

Cellular Component

GO:0005634 nucleus
GO:0042555 MCM complex

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Entry type

Status

Per-residue features