MIA_03519_1

Protein

Length

494 amino acids

Protein function

EGGNOG:	0PFH7	UGA2	succinate-semialdehyde dehydrogenase
SGD closest match:	S000000210	UGA2	Succinate-semialdehyde dehydrogenase [NADP(+)]
CGD closest match:	CAL0000192412	UGA2	Uga2p

Protein alignments

	%id	Aln length
MCA_02744_1	80.164%	489	MCA_02744_1
A0A0J9X3P0_GEOCN	70.600%	483	Similar to Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source OS=Geotrichum candidum GN=BN980_GECA01s11296g PE=4 SV=1
A0A167ESY4_9ASCO	61.350%	489	Succinate-semialdehyde dehydrogenase (NAD(P)(+)) OS=Sugiyamaella lignohabitans GN=UGA2 PE=3 SV=1
Q6C0B4_YARLI	60.896%	491	YALI0F26191p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26191g PE=3 SV=1
UniRef50_A0A162Y620	60.575%	487	Succinate-semialdehyde dehydrogenase [NAD(P)+] n=1 Tax=Didymella rabiei TaxID=5454 RepID=A0A162Y620_DIDRA
A0A1E3PG13_9ASCO	60.373%	482	Succinic semialdehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47537 PE=3 SV=1
A0A060T3V5_BLAAD	60.460%	478	ARAD1A12386p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12386g PE=3 SV=1
A0A1E4TJ66_9ASCO	56.159%	479	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_381 PE=3 SV=1
Q59T88_CANAL	55.967%	486	Uga2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UGA2 PE=3 SV=1
UGA2_YEAST	52.653%	490	Succinate-semialdehyde dehydrogenase [NADP(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UGA2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0776

Protein family membership

Succinate semialdehyde dehydrogenase (IPR010102)

Domains and repeats

Domain
3 - 278
Aldehyde dehydrogenase N-terminal domain (IPR016162)
Domain
7 - 490
Aldehyde/histidinol dehydrogenase (IPR016161)
Aldehyde dehydrogenase domain (IPR015590)

1 50 100 150 200 250 300 350 400 450 494

Detailed signature matches

IPR010102

Succinate semialdehyde dehydrogenase
1. TIGR01780
  
  36 - 486
  
  TIGRFAMs
  TIGR01780 (TIGR01780)
IPR016162

Aldehyde dehydrogenase N-terminal domain
1. G3DSA:3.40.60...
  
  3 - 278
  
  GENE3D
  G3DSA:3.40.605.10 (G3DSA:3.40.605.10)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  7 - 490
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR015590

Aldehyde dehydrogenase domain
1. PF00171 (Aldedh)
  
  26 - 488
  
  Pfam
  PF00171 (Aldedh)
IPR029510

Aldehyde dehydrogenase, glutamic acid active site
1. PS00687 (ALDEHYDE_D...)
  
  262 - 269
  
  PROSITE patterns
  PS00687 (ALDEHYDE_DEHYDR_GLU)

no IPR

Unintegrated signatures

Coil

53 - 73

COILS
Coil (Coil)
G3DSA:3.40.30...

279 - 474

GENE3D
G3DSA:3.40.309.10 (G3DSA:3.40.309.10)
cd07103 (ALDH_F5_SS...)

36 - 488

CDD
cd07103 (ALDH_F5_SSADH_GabD)

Residue annotation

tetramerization in...

74T

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

83R

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

124W

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

127E

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

128E

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

130P

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

131R

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

132I

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

133Y

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

134G

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

135D

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

136T

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

137I

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

138P

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

144R

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

145R

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

146M

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

151Q

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

235K

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

247K

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

251S

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

254A

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

311D

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

315S

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

362K

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

431K

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

433V

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

434G

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

438R

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

440A

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

443L

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

445T

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

446G

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

447M

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

448V

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

449G

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

450V

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

451N

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

457E

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

460L

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

461P

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

467E

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

472R

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

484S

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

485I

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

486K

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

487T

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

488V

tetramerization interface
74T, 83R, 124W, 127E, 128E, 130P, 131R, 132I, 133Y, 134G, 135D, 136T, 137I, 138P, 144R, 145R, 146M, 151Q, 235K, 247K, 251S, 254A, 311D, 315S, 362K, 431K, 433V, 434G, 438R, 440A, 443L, 445T, 446G, 447M, 448V, 449G, 450V, 451N, 457E, 460L, 461P, 467E, 472R, 484S, 485I, 486K, 487T, 488V
CDD
cd07103 (ALDH_F5_SSADH_GabD)
NAD(P) binding sit...

159I

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

160T

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

161P

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

162W

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

163N

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

171R

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

186K

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

188A

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

189A

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

239F

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

240T

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

241G

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

242S

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

245V

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

248I

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

249L

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

263E

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

264L

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

265G

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

297C

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

396E

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

398F

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

424L

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

462F

NAD(P) binding site
159I, 160T, 161P, 162W, 163N, 171R, 186K, 188A, 189A, 239F, 240T, 241G, 242S, 245V, 248I, 249L, 263E, 264L, 265G, 297C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)
catalytic residues...

163N

catalytic residues
163N, 263E, 294G, 297C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

263E

catalytic residues
163N, 263E, 294G, 297C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

294G

catalytic residues
163N, 263E, 294G, 297C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

297C

catalytic residues
163N, 263E, 294G, 297C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

Protein sequence

>MIA_03519_1
MATHSVPKLKNPELLQERSFINGEFVAAKSGKTFDVYDPATGSKIAAPPEMSLDELKHAIESAHDALAVLKKTTGRQRSR
WLRKWYDLMIENQEDLATIITWENGKVLADAHGEIAYAAGFFEWFSEEAPRIYGDTIPSAVPGRRMYTIKQPVGVCGIIT
PWNFPSGMITRKIGAALAAGCPVVVKPAAETPFSALALAYLAQKAGIPAGVVNVVTADKGTIDFGRELCENPIVKKVSFT
GSTRVGKILMSQSAGTLKKLSLELGGNAPYIVFEDGDIDAAITSALAAKYRGNGQVCVSPNRFYVHEKIYDEFCSKITAK
VSSIYKPGAGFNPDVNLGPLINEAAVKKVKSHVEDVVAKNGKILTGGEPLPGLGPNFFPATVVSDVTKDMIINHEETFGP
LVSIIKFSSEEDVIAKANNVLVGLASYFFTKDVGRAYRVAEALETGMVGVNTGLISEQALPFGGVKESGFGREGSKYGVE
EYLSIKTVVVDSNV

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0009450 gamma-aminobutyric acid catabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features