MCA_02744_1

Protein

Length

518 amino acids

Gene name: UGA2

Description: Succinate-semialdehyde dehydrogenase [NADP(+)]

Browser: contigB:2235526-2237083-

RNA-seq: read pairs 1069, FPKM 25.5, percentile rank 48.0% (100% = highest expression)

Protein function

Annotation:		UGA2	Succinate-semialdehyde dehydrogenase [NADP(+)]
KEGG:	K00135	gabD	succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
EGGNOG:	0PFH7	UGA2	succinate-semialdehyde dehydrogenase
SGD closest match:	S000000210	UGA2	Succinate-semialdehyde dehydrogenase [NADP(+)]
CGD closest match:	CAL0000192412	UGA2	Uga2p

Protein alignments

	%id	Aln length	E-value
MIA_03519_1	80.16%	489	0.0	MIA_03519_1
A0A0J9X3P0_GEOCN	69.57%	483	0.0	Similar to Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source OS=Geotrichum candidum GN=BN980_GECA01s11296g PE=4 SV=1
A0A167ESY4_9ASCO	60.44%	503	0.0	Succinate-semialdehyde dehydrogenase (NAD(P)(+)) OS=Sugiyamaella lignohabitans GN=UGA2 PE=3 SV=1
Q6C0B4_YARLI	59.96%	502	0.0	YALI0F26191p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26191g PE=3 SV=1
A0A1E3PG13_9ASCO	60.48%	496	0.0	Succinic semialdehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47537 PE=3 SV=1
UniRef50_A0A162Y620	58.30%	506	0.0	Succinate-semialdehyde dehydrogenase [NAD(P)+] n=1 Tax=Didymella rabiei TaxID=5454 RepID=A0A162Y620_DIDRA
A0A060T2P6_BLAAD	56.54%	497	0.0	ARAD1C29766p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29766g PE=3 SV=1
UGA2_YEAST	54.02%	485	0.0	Succinate-semialdehyde dehydrogenase [NADP(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UGA2 PE=1 SV=2
A0A1E4TJ66_9ASCO	53.75%	493	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_381 PE=3 SV=1
Q59T88_CANAL	54.51%	488	2e-175	Uga2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UGA2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9869
Predicted cleavage: 23

Protein family membership

Succinate semialdehyde dehydrogenase (IPR010102)

Domains and repeats

Domain
16 - 514
Aldehyde/histidinol dehydrogenase (IPR016161)
Aldehyde dehydrogenase domain (IPR015590)
Domain
30 - 301
Aldehyde dehydrogenase N-terminal domain (IPR016162)

1 50 100 150 200 250 300 350 400 450 518

Detailed signature matches

IPR010102

Succinate semialdehyde dehydrogenase
1. TIGR01780
  
  59 - 510
  
  TIGRFAMs
  TIGR01780 (TIGR01780)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  16 - 514
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR016162

Aldehyde dehydrogenase N-terminal domain
1. G3DSA:3.40.60...
  
  30 - 301
  
  GENE3D
  G3DSA:3.40.605.10 (G3DSA:3.40.605.10)
IPR015590

Aldehyde dehydrogenase domain
1. PF00171 (Aldedh)
  
  49 - 512
  
  Pfam
  PF00171 (Aldedh)
IPR029510

Aldehyde dehydrogenase, glutamic acid active site
1. PS00687 (ALDEHYDE_D...)
  
  285 - 292
  
  PROSITE patterns
  PS00687 (ALDEHYDE_DEHYDR_GLU)

no IPR

Unintegrated signatures

G3DSA:3.40.30...

302 - 498

GENE3D
G3DSA:3.40.309.10 (G3DSA:3.40.309.10)
cd07103 (ALDH_F5_SS...)

59 - 512

CDD
cd07103 (ALDH_F5_SSADH_GabD)

Residue annotation

tetramerization in...

97T

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

106R

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

147W

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

150E

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

151E

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

153P

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

154R

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

155I

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

156Y

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

157G

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

158D

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

159T

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

160I

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

161P

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

167R

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

168R

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

169M

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

174Q

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

258K

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

270K

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

274Q

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

277S

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

334Q

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

338D

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

386K

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

455K

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

457V

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

458G

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

462R

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

464A

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

467I

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

469T

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

470G

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

471M

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

472V

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

473G

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

474L

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

475N

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

481E

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

484L

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

485P

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

491E

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

496R

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

508V

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

509T

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

510K

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

511T

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)

512V

tetramerization interface
97T, 106R, 147W, 150E, 151E, 153P, 154R, 155I, 156Y, 157G, 158D, 159T, 160I, 161P, 167R, 168R, 169M, 174Q, 258K, 270K, 274Q, 277S, 334Q, 338D, 386K, 455K, 457V, 458G, 462R, 464A, 467I, 469T, 470G, 471M, 472V, 473G, 474L, 475N, 481E, 484L, 485P, 491E, 496R, 508V, 509T, 510K, 511T, 512V
CDD
cd07103 (ALDH_F5_SSADH_GabD)
NAD(P) binding sit...

182I

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

183T

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

184P

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

185W

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

186N

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

194R

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

209K

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

211A

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

212S

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

262F

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

263T

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

264G

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

265S

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

268V

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

271L

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

272L

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

286E

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

287L

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

288G

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

320C

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

420E

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

422F

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

448L

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

486F

NAD(P) binding site
182I, 183T, 184P, 185W, 186N, 194R, 209K, 211A, 212S, 262F, 263T, 264G, 265S, 268V, 271L, 272L, 286E, 287L, 288G, 320C, 420E, 422F, 448L, 486F
CDD
cd07103 (ALDH_F5_SSADH_GabD)
catalytic residues...

186N

catalytic residues
186N, 286E, 317G, 320C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

286E

catalytic residues
186N, 286E, 317G, 320C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

317G

catalytic residues
186N, 286E, 317G, 320C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

320C

catalytic residues
186N, 286E, 317G, 320C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

Protein sequence

>MCA_02744_1
MSALLNTFKQTQLLRNIITTRSMASLATPPTLKNPKLLQPKSYINGQFVSAKSGKTFDVYDPATGEKIGSPPEMSLDELK
EAITHAHNALPALRKTTGRERSRWLRKWYDLMLENKDDLATLVTWENGKVLADAVGEIAYSAGFFEWFSEEAPRIYGDTI
PSAVPGRRMYTIKQPVGVAGIITPWNFPSGMITRKVGAAIAAGCPVVVKPASETPFSATALAVLAEEAGVPAGVFNVVTG
HTSTAEFGKELCTNPLVKKVSFTGSTRVGKLLMQQSSSTLKKLSLELGGNAPYIVFEDGDMDAAIESALAAKYRGNGQVC
VSPNRFYIHSAIYQEFCDRLTAKVQEIYATPGSGFDPASKLGPLINEAAVNKVDSHVKDAVSKNGKILVGGKKLTDLGPN
FYPATVIADVNTDMLVTKEETFGPLVSIIKFDSEEDVIQKANNVDVGLAAYFFTKDVGRAYRVAEAIETGMVGLNTGLIS
EQALPFGGIKESGFGREGSKYGVDEYLVTKTVVVATNV

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0009450 gamma-aminobutyric acid catabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features