Protein

MIA_03495_1

Length
553 amino acids

Browser: contig04:1361004-1362666-

Protein function

EGGNOG:0PFA5COX10Converts protoheme IX and farnesyl diphosphate to heme O (By similarity)
SGD closest match:S000006093COX10Protoheme IX farnesyltransferase, mitochondrial
CGD closest match:CAL0000197403orf19.3167Protoheme IX farnesyltransferase, mitochondrial

Protein alignments

%idAln lengthE-value
MCA_05764_166.017%4620.0MCA_05764_1
A0A0J9X4M7_GEOCN65.743%3971.79e-179Protoheme IX farnesyltransferase, mitochondrial OS=Geotrichum candidum GN=BN980_GECA03s01209g PE=3 SV=1
A0A161HHW8_9ASCO65.252%3774.79e-167Protoheme IX farnesyltransferase, mitochondrial OS=Sugiyamaella lignohabitans GN=COX10 PE=3 SV=1
A0A060T4H2_BLAAD61.140%3861.06e-158Protoheme IX farnesyltransferase, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B03476g PE=3 SV=1
COX10_YARLI67.901%3241.21e-156Protoheme IX farnesyltransferase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=COX10 PE=3 SV=1
UniRef50_Q6C0L267.901%3242.80e-153Protoheme IX farnesyltransferase, mitochondrial n=24 Tax=Saccharomycetales TaxID=4892 RepID=COX10_YARLI
A0A1E3PP24_9ASCO58.883%3949.28e-155Protoheme IX farnesyltransferase, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81747 PE=3 SV=1
COX10_YEAST54.774%3989.02e-145Protoheme IX farnesyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COX10 PE=3 SV=1
A0A1D8PNE8_CANAL53.299%3942.11e-137Protoheme IX farnesyltransferase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3167 PE=3 SV=1
A0A1E4TGJ5_9ASCO47.977%3461.18e-105Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_25060 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5717

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR000537
    UbiA prenyltransferase family
    1. PF01040 (UbiA)
  2. Family IPR006369
    Protohaem IX farnesyltransferase
    1. MF_00154 (CyoE_CtaB)
    2. cd13957 (PT_UbiA_Cox10)
    3. TIGR01473
  3. Family IPR016315
    Protohaem IX farnesyltransferase, mitochondria
    1. PIRSF001773 (COX10)
  4. SITE IPR030470
    UbiA prenyltransferase conserved site
    1. PS00943 (UBIA)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. mobidb-lite (disord...)

Protein sequence

>MIA_03495_1
MLLKSRATGFANQQLLSFSIGYSAVVFADIESCARTRRFYVSQNRSPVRRRTFSSSGTLASVASSGLASSPSSSSSKPFD
FLSNSFLQIALSSTSSTPNNSESSQTPIPRTANSTEDAAAKYESLAEDAALNPFPTPIRVSLSPDSKPVVDFATKAFSCV
DKDQTTKSSISNASKATTESVPPPFVMTPVDAATRKSVSKTKTQSPFAPYIALTKPRLSALVVLSAMSAYALTPNHATLS
QLLFLTIGTTLASGSANAINMGREYQYDALMTRTRTRPVVRGLITPNQAFSFAAISGVVGVSSLYWGVNPTVAFLGASNI
ILYGIIYTTLKRKSISNTWVGAVVGAIPPLMGWAASSSLADPGAWCLAALLYAWQFPHFNALSHSIRDEYKNAGYVMAAW
TNPALNARVALRYSVLMFPICICMSYFNITDWVFAFDSSLVNGWLAYWAYKFWVEQRSVKPIADRNGILHQTGLPFNMNS
NGSGQGSYSSSAKCNGFARKLFWGSVIHLPAVLLLAMIHKKGQWDWLFGSGEDEEDEDGTVKLNESGQSVLQS

GO term prediction

Biological Process

GO:0006783 heme biosynthetic process
GO:0048034 heme O biosynthetic process

Molecular Function

GO:0008495 protoheme IX farnesyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups

Cellular Component

GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane