Protein

MIA_03483_1

Length
413 amino acids

Browser: contig04:1311688-1312930-

Protein function

EGGNOG:0PIR0RAI1Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates
SGD closest match:S000003215RAI1Decapping nuclease RAI1
CGD closest match:CAL0000178137RAI1Decapping nuclease RAI1

Protein alignments

%idAln lengthE-value
MCA_03646_145.278%4138.79e-124MCA_03646_1
A0A0J9XEI3_GEOCN43.529%4259.91e-108Similar to Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures OS=Geotrichum candidum GN=BN980_GECA10s03013g PE=4 SV=1
UniRef50_A0A0J9XEI343.529%4252.03e-104Similar to Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XEI3_GEOCN
A0A060TD59_BLAAD40.144%4168.29e-104ARAD1B21890p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21890g PE=4 SV=1
A0A1E3PCX4_9ASCO41.422%4082.07e-102Putative suppressor of exonuclease defects OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53537 PE=4 SV=1
DXO_CANAL34.450%4181.98e-70Decapping nuclease RAI1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAI1 PE=1 SV=4
DXO_YEAST34.458%4151.48e-59Decapping nuclease RAI1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAI1 PE=1 SV=3
DXO_YARLI29.557%4061.43e-48Decapping nuclease RAI1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RAI1 PE=3 SV=3
A0A1E4TF94_9ASCO30.986%3555.51e-48Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13484 PE=4 SV=1
A0A161HJC2_9ASCO39.521%1671.97e-23Rai1p OS=Sugiyamaella lignohabitans GN=RAI1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1003

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 413

Detailed signature matches

  1. Domain IPR013961
    RAI1-like
    1. PF08652 (RAI1)

Protein sequence

>MIA_03483_1
MTQLSLETRPEKPTALRRPKQIHAYSIDKSGEQHIEDNQSLRYFYYPDTALAGRPNLSSGFSSFVKRDESTPKHLNELLR
ALTHFEKVKNDGKKVKVDIITYRGVMTKLLVLTQVLKNRFGDEDVTINATYFDGSLLMELDYTLEQQKKQGREVNKTDQE
KERDQIMTYWGYKFESLATLSMPWSQCTRDEIEGRDKTVVDNISEYCCLVRTGVGKVKMVLGAEVDGIYDYNPYDKFDLS
GDHDRKPSEKLFDDDTDKEKDIISHYVELKTTKIVTNPRSASTFLLKLLRTWAQCFLIGIPKVVYGFRDDNGYLKSVEEY
DTEDLPKLIASAKYLEDYKKWNGNECIAFYSAAVEWIKNSIPNEEGQAWRIQYKRGDNVLKLFRVSDPQEEQQLVEGMVE
KGFREWRKSTNVQ

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.