Protein

MIA_03454_1

Length
1,402 amino acids

Browser: contig04:1246988-1251269-

Protein function

EGGNOG:0PGYHUBP2ubiquitin carboxyl-terminal hydrolase
SGD closest match:S000005650UBP2Ubiquitin carboxyl-terminal hydrolase 2
CGD closest match:CAL0000174377CAALFM_CR05980WAUbiquitin-specific protease

Protein alignments

%idAln lengthE-value
MCA_04881_145.324%12510.0MCA_04881_1
A0A0J9X8Q9_GEOCN37.349%7473.67e-125Similar to Saccharomyces cerevisiae YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins OS=Geotrichum candidum GN=BN980_GECA06s00318g PE=3 SV=1
UniRef50_A0A0J9X8Q937.349%7477.51e-122Similar to Saccharomyces cerevisiae YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X8Q9_GEOCN
A0A060T713_BLAAD33.853%6411.63e-85ARAD1B24112p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B24112g PE=3 SV=1
A0A167ENJ7_9ASCO33.126%6431.19e-82Ubp2p OS=Sugiyamaella lignohabitans GN=UBP2 PE=3 SV=1
Q6CAE5_YARLI36.896%3932.25e-72YALI0D03531p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D03531g PE=3 SV=1
A0A1E3PMP0_9ASCO38.122%3622.70e-69Cysteine proteinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_57578 PE=3 SV=1
UBP2_YEAST39.067%3432.74e-66Ubiquitin carboxyl-terminal hydrolase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP2 PE=1 SV=2
A0A1D8PT66_CANAL37.861%3462.29e-62Ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR05980WA PE=3 SV=1
A0A1E4TE20_9ASCO35.627%4072.18e-56Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_99732 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0449

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1402

Detailed signature matches

  1. Domain IPR025305
    UCH repeated domain
    1. PF13446 (RPT)
  2. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  3. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  4. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00972 (USP_1)
    2. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.90.70.10
  3. SSF54001 (Cysteine ...)
  4. cd02666 (Peptidase_...)
  5. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02666

Protein sequence

>MIA_03454_1
MSDSNTSPPPKLSSVPSSFIIKGGVSAPRLIDDILHMVIGPRYLNNDPVTAASNLDLRRQTPWSIAISGDPRLPEFVTTS
SFLEFYSLLFSLDDPVFIHLHAEIELGAAPPENELMDFHLCKPSVESLDSDQETYEYKCSITATHLKLIFHRPVFTKEDW
ATFHTSAIAKRFQKFKHLSNNSSSVPPMPISCLHTLYKIISKPILDPTPSPIFREHFSVNVRTTPEFLIKHLYFTLKEDD
SKLYPPDIYEANSSPELREIRRDYIRKLHEVVIYANTYFPNVSNSQSAMTQSFTLKNSLPILRRLLSDTDPRLPDLSYLK
NQSFYGNKTYGSSSILPSRFDLQMYTMLGATHDLSNSAISKRYDLQAFQDPENKPYYFEALLAVAKSRQSEILETKATEL
LSLGETSASNLAQAYGQYLLNFDKTTTELPLDEDYLIDCYKHRSKEFPEEEPTLRNALLTIANHRNNARILSFLESKSMT
LPEAYSELGLTKDSNEEYIHLAYETKMQEARPEEAKLAKLALRTIAIDRKSKMLLNLYETAVKHDHDHGGIDQNMTLSEA
ITILRIPQELVDEAQTNNASHSLIVQHFEANSGNDPERILEQRQALRVLSKHLKSKKIESYLSGAPDSDFIRNSLWPVGL
ENIGNTCYLNSLLQFYFTITPLRNAVIDFCDNSTNQIDLAHAKEKRVGGRVVTKGEIVRSRQFVCYLGELFKQLIHTPLA
SIAPKKELAFLALVPSQIDPRMEEYESLVKTTEIDLNAKLTTSTQGTVVDSSILGLSKAISRSDPIYEDDEKLLSDDDES
ITAESEKGGTVIVHDMDDGSSVKCFFMADELPKVSSDDDVVMVDDVSTDSSESPKRSREALSPKFDSSARKRDRKSIDST
STSAGNEYSSIDRKESIVTVRSIDPPKTSEQKRQMDDAMAIGGQQDVTECIENVLFQIEGAFDALGYDEDGEQLDMVKEL
FYGATKQLIEDPETGKVGDSKTERFSMLIVNVEDKPQNMYEVIDTYFDDSLVELGKKQVIRHITATKLPPVLQVQIQRVQ
FDKVTQRAYKSKAPIRLLDTIYLDRYMDSDEPIMVAKRKELKQWKARISKLRKEEDEINDLVGNGITIIEALESTKTFLV
AQNAAAAEGKEALAQVSPQTVEFLEKHVIQLKYKLESIRAEIADLENKLVHQFDDMHHVGYKLHSVFIHRGQATFGHYWV
HIHDFRSNIYRMYNDKTVAEVSADEVMGIPPPGSTVLKDADATAYYVTYVREDSLDLVDAVVRDIVEVDDGKDNDDVNKN
AMAESGSNVNNEDDDEILIVGENKVEDGVAEFSTAAAAISKALAEGSVDNGDEDTSATSTSAGSTTSTTTTTTTNETTTS
KSPQPPKLSFAEIVAGKKPPPPVPSKSDKKKEDEEKENLISL

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.