MIA_03391_1

Protein

Length

890 amino acids

Protein function

EGGNOG:	0PHNB	PGUG_03524	Multifunctional beta-oxidation protein
SGD closest match:	S000001717	FOX2	Peroxisomal hydratase-dehydrogenase-epimerase
CGD closest match:	CAL0000176075	FOX2	Bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase

Protein alignments

	%id	Aln length
MCA_03518_1	82.074%	887	MCA_03518_1
A0A0J9XH79_GEOCN	75.169%	886	Similar to Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway OS=Geotrichum candidum GN=BN980_GECA16s01759g PE=4 SV=1
F2Z6I5_YARLI	67.338%	894	YALI0E15378p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E15378g PE=4 SV=1
A0A060T2Z2_BLAAD	66.853%	893	3-hydroxy-alcyl-CoA dehydrogenase and enoyl-CoA hydratase OS=Blastobotrys adeninivorans GN=AFOX2 PE=4 SV=1
A0A167D5H7_9ASCO	66.183%	896	Bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 OS=Sugiyamaella lignohabitans GN=FOX2 PE=4 SV=1
UniRef50_I1RZ25	63.667%	900	Uncharacterized protein n=52 Tax=leotiomyceta TaxID=716546 RepID=I1RZ25_GIBZE
A0A1E4T9L4_9ASCO	62.281%	912	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_33032 PE=4 SV=1
A0A1E3PDQ2_9ASCO	62.413%	862	Multifunctional beta-oxidation enzyme OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84196 PE=4 SV=1
A0A1D8PJ13_CANAL	48.736%	870	Bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FOX2 PE=4 SV=1
FOX2_YEAST	49.717%	883	Peroxisomal hydratase-dehydrogenase-epimerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOX2 PE=2 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0380

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
4 - 254
NAD(P)-binding domain (IPR016040)
308 - 551
NAD(P)-binding domain (IPR016040)
618 - 755
HotDog domain (IPR029069)
765 - 879
HotDog domain (IPR029069)
MaoC-like domain (IPR002539)

1 100 200 300 400 500 600 700 800 890

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PR00080 (SDRFAMILY)
  
  90 - 101
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  143 - 151
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  163 - 182
  
  PRINTS
  PR00080 (SDRFAMILY)
2. PR00081 (GDHRDH)
  
  383 - 394
  
  PRINTS
  PR00081 (GDHRDH)
  
  314 - 331
  
  PRINTS
  PR00081 (GDHRDH)
  
  456 - 475
  
  PRINTS
  PR00081 (GDHRDH)
  
  430 - 446
  
  PRINTS
  PR00081 (GDHRDH)
  
  477 - 494
  
  PRINTS
  PR00081 (GDHRDH)
  
  500 - 520
  
  PRINTS
  PR00081 (GDHRDH)
3. PF00106 (adh_short)
  
  313 - 498
  
  Pfam
  PF00106 (adh_short)
  
  9 - 195
  
  Pfam
  PF00106 (adh_short)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  4 - 254
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  308 - 551
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR029069

HotDog domain
1. SSF54637 (Thioester...)
  
  618 - 755
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
  
  767 - 879
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
IPR002539

MaoC-like domain
1. PF01575 (MaoC_dehyd...)
  
  765 - 876
  
  Pfam
  PF01575 (MaoC_dehydratas)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  150 - 178
  
  PROSITE patterns
  PS00061 (ADH_SHORT)
  
  443 - 471
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

G3DSA:3.10.12...

613 - 761

GENE3D
G3DSA:3.10.129.10 (G3DSA:3.10.129.10)

763 - 890

GENE3D
G3DSA:3.10.129.10 (G3DSA:3.10.129.10)
G3DSA:3.40.50...

289 - 540

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

3 - 288

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
SM00822 (PKS_KR)

313 - 487

SMART
SM00822 (PKS_KR)
cd03448 (HDE_HSD)

767 - 883

CDD
cd03448 (HDE_HSD)
cd05353 (hydroxyacy...)

308 - 546

CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

22 - 253

CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

Residue annotation

homodimer interfac...

31K

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

106S

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

107F

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

108K

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

110L

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

111K

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

112D

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

115W

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

116D

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

119Y

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

123T

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

124Y

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

127Y

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

130A

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

131R

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

134W

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

135P

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

151A

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

152A

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

153G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

154L

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

155Y

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

156G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

157N

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

158F

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

159G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

161T

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

164S

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

165A

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

168L

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

169G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

171V

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

172G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

173F

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

175E

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

176T

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

177L

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

179K

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

180E

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

182F

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

183K

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

185N

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

208M

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

211R

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

212L

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

216Y

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

219P

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

220L

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

222G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

223Y

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

224L

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

231E

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

235I

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

236F

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

237E

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

239G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

240A

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

241G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

242F

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

243Y

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

244A

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

245K

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

246V

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

247R

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

248W

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

249E

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

250R

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

251S

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

252A

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

253G

homodimer interface
31K, 106S, 107F, 108K, 110L, 111K, 112D, 115W, 116D, 119Y, 123T, 124Y, 127Y, 130A, 131R, 134W, 135P, 151A, 152A, 153G, 154L, 155Y, 156G, 157N, 158F, 159G, 161T, 164S, 165A, 168L, 169G, 171V, 172G, 173F, 175E, 176T, 177L, 179K, 180E, 182F, 183K, 185N, 208M, 211R, 212L, 216Y, 219P, 220L, 222G, 223Y, 224L, 231E, 235I, 236F, 237E, 239G, 240A, 241G, 242F, 243Y, 244A, 245K, 246V, 247R, 248W, 249E, 250R, 251S, 252A, 253G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
NAD binding site c...

38N

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

39D

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

40L

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

42G

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

74S

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

75V

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

98N

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

99A

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

100G

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

101I

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

121V

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

122H

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

148T

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

149S

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

150S

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

163Y

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

167K

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

193P

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

194L

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

195A

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

197S

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

198R

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

199L

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

200T

NAD binding site
38N, 39D, 40L, 42G, 74S, 75V, 98N, 99A, 100G, 101I, 121V, 122H, 148T, 149S, 150S, 163Y, 167K, 193P, 194L, 195A, 197S, 198R, 199L, 200T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
active site cd05353

122H

active site
122H, 150S, 163Y, 167K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

150S

active site
122H, 150S, 163Y, 167K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

163Y

active site
122H, 150S, 163Y, 167K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

167K

active site
122H, 150S, 163Y, 167K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
homodimer interfac...

308V

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

335L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

399S

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

400F

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

401A

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

403M

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

404T

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

405D

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

408W

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

409E

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

412Y

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

416L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

417R

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

420Y

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

423T

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

424K

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

427W

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

428P

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

444T

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

445S

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

446G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

447I

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

448Y

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

449G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

450N

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

451F

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

452G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

454A

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

457A

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

458S

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

461A

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

462G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

464L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

465G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

466F

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

468R

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

469A

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

470L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

472L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

473E

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

475A

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

476K

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

478N

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

501M

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

504S

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

505F

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

509Y

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

512P

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

513L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

515T

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

516L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

517L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

524V

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

528L

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

529Y

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

530E

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

532G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

533S

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

534G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

535W

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

536V

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

537G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

538A

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

539T

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

540R

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

541W

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

542Q

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

543R

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

544S

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

545G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

546G

homodimer interface
308V, 335L, 399S, 400F, 401A, 403M, 404T, 405D, 408W, 409E, 412Y, 416L, 417R, 420Y, 423T, 424K, 427W, 428P, 444T, 445S, 446G, 447I, 448Y, 449G, 450N, 451F, 452G, 454A, 457A, 458S, 461A, 462G, 464L, 465G, 466F, 468R, 469A, 470L, 472L, 473E, 475A, 476K, 478N, 501M, 504S, 505F, 509Y, 512P, 513L, 515T, 516L, 517L, 524V, 528L, 529Y, 530E, 532G, 533S, 534G, 535W, 536V, 537G, 538A, 539T, 540R, 541W, 542Q, 543R, 544S, 545G, 546G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
NAD binding site c...

319G

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

322A

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

323G

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

324I

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

342N

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

343D

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

344F

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

346D

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

367N

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

368V

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

391N

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

392A

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

393G

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

394I

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

414V

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

415H

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

441T

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

442T

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

443S

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

456Y

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

460K

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

486P

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

487N

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

488A

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

490T

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

491A

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

492M

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

493T

NAD binding site
319G, 322A, 323G, 324I, 342N, 343D, 344F, 346D, 367N, 368V, 391N, 392A, 393G, 394I, 414V, 415H, 441T, 442T, 443S, 456Y, 460K, 486P, 487N, 488A, 490T, 491A, 492M, 493T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
active site cd05353

415H

active site
415H, 443S, 456Y, 460K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

443S

active site
415H, 443S, 456Y, 460K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

456Y

active site
415H, 443S, 456Y, 460K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

460K

active site
415H, 443S, 456Y, 460K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
dimer interaction ...

782D

dimer interaction site
782D, 785A, 788R, 789L, 793Y, 795P, 799D
CDD
cd03448 (HDE_HSD)

785A

dimer interaction site
782D, 785A, 788R, 789L, 793Y, 795P, 799D
CDD
cd03448 (HDE_HSD)

788R

dimer interaction site
782D, 785A, 788R, 789L, 793Y, 795P, 799D
CDD
cd03448 (HDE_HSD)

789L

dimer interaction site
782D, 785A, 788R, 789L, 793Y, 795P, 799D
CDD
cd03448 (HDE_HSD)

793Y

dimer interaction site
782D, 785A, 788R, 789L, 793Y, 795P, 799D
CDD
cd03448 (HDE_HSD)

795P

dimer interaction site
782D, 785A, 788R, 789L, 793Y, 795P, 799D
CDD
cd03448 (HDE_HSD)

799D

dimer interaction site
782D, 785A, 788R, 789L, 793Y, 795P, 799D
CDD
cd03448 (HDE_HSD)
substrate-binding ...

786Y

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

792D

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

794N

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

797H

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

814H

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

816L

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

819F

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

822S

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

826L

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

833F

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

836A

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

838V

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

840F

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

854A

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

863F

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

865T

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

874A

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)

880V

substrate-binding tunnel
786Y, 792D, 794N, 797H, 814H, 816L, 819F, 822S, 826L, 833F, 836A, 838V, 840F, 854A, 863F, 865T, 874A, 880V
CDD
cd03448 (HDE_HSD)
active site cd03448

787Y

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)

791G

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)

792D

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)

794N

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)

797H

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)

812I

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)

815G

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)

816L

active site
787Y, 791G, 792D, 794N, 797H, 812I, 815G, 816L
CDD
cd03448 (HDE_HSD)
catalytic site cd0...

792D

catalytic site
792D, 794N, 797H, 815G
CDD
cd03448 (HDE_HSD)

794N

catalytic site
792D, 794N, 797H, 815G
CDD
cd03448 (HDE_HSD)

797H

catalytic site
792D, 794N, 797H, 815G
CDD
cd03448 (HDE_HSD)

815G

catalytic site
792D, 794N, 797H, 815G
CDD
cd03448 (HDE_HSD)
substrate binding ...

823G

substrate binding site
823G, 826L, 833F
CDD
cd03448 (HDE_HSD)

826L

substrate binding site
823G, 826L, 833F
CDD
cd03448 (HDE_HSD)

833F

substrate binding site
823G, 826L, 833F
CDD
cd03448 (HDE_HSD)

Protein sequence

>MIA_03391_1
MTELRYDGKVVVVTGAGGGLGKAYALFFASKGASVVVNDLGGSFKGEGNSTKAADLVVEEIIKAGGKAVANYDSVEFGDK
IIETAVKAFGTVHIVINNAGILRDVSFKNLKDSDWDLIYKVHTYGSYKVARAAWPYFRKQKYGRIINTSSAAGLYGNFGQ
TNYSAAKLGLVGFTETLAKEGFKYNIFANAIAPLAASRLTETIMTKEMLDRLSPNYIVPLVGYLTHESSKETGGIFELGA
GFYAKVRWERSAGQVFKTDETFTPSAILKAWNKINDFSNPSYPTGPADFITLAEESTKTGPAAQGEPVNYNGQVVIVTGA
GAGIGRAYALLLGKLGAKVVVNDFVDPEPVVNEIKKAGGIAVGDKSNVVEGHKVVETALKAFGTIHAIINNAGILRDKSF
ANMTDDQWEAVYQVHLRGTYAVTKAAWPVLLKQKYGRIVNTTSTSGIYGNFGQANYASAKAGILGFGRALALEGAKYNIF
VNTIAPNAGTAMTKSIFTEEMLESFKPDYIAPLVTLLASDKAPVTGGLYEAGSGWVGATRWQRSGGKFYQGPPPSIETLA
KDWKNIVNFDDGRAITVSSFKETSQTILGPVLEASKPKKVDFTPVDPKDYNKLEDVADFTYTHRDVILYNLCVGAHATDL
KYSFEGAEDFQVVPTFGVIPYFATSIDFNRLVPNFNPMKLLHGEQYLEIRKWPLPTEGTLVNIARPLEVIDKGKAAVVIS
EVVTKNKATGEDIFYNVSSTFIRGSGGWGGPTRGANRGAITAANKPPARNPDFVQSYKIDADKAAYYRLCGDYNPLHIDP
AFAAVGNFPKPILHGLATFGISGKILYDKFGPFKNAKVRFSGHVFPGETVQVEAWKEGSKVIFQTRVVDRNTIAISAAAV
ELASKPSHKL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_03391_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component