MCA_03518_1

Protein

Length

894 amino acids

Gene name: FOX2

Description: Peroxisomal hydratase-dehydrogenase-epimerase

Browser: contigC:203147-205904-

RNA-seq: read pairs 2621, FPKM 36.2, percentile rank 58.0% (100% = highest expression)

Protein function

Annotation:		FOX2	Peroxisomal hydratase-dehydrogenase-epimerase
KEGG:	K14729	FOX2	multifunctional beta-oxidation protein [EC:4.2.1.- 1.1.1.-]
EGGNOG:	0PHNB	PGUG_03524	Multifunctional beta-oxidation protein
SGD closest match:	S000001717	FOX2	Peroxisomal hydratase-dehydrogenase-epimerase
CGD closest match:	CAL0000176075	FOX2	Bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase

Protein alignments

	%id	Aln length
MIA_03391_1	81.96%	887	MIA_03391_1
A0A0J9XH79_GEOCN	72.98%	892	Similar to Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway OS=Geotrichum candidum GN=BN980_GECA16s01759g PE=4 SV=1
F2Z6I5_YARLI	66.89%	903	YALI0E15378p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E15378g PE=4 SV=1
A0A167D5H7_9ASCO	66.41%	896	Bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 OS=Sugiyamaella lignohabitans GN=FOX2 PE=4 SV=1
A0A060T2Z2_BLAAD	64.88%	897	3-hydroxy-alcyl-CoA dehydrogenase and enoyl-CoA hydratase OS=Blastobotrys adeninivorans GN=AFOX2 PE=4 SV=1
A0A1E4T9L4_9ASCO	61.67%	908	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_33032 PE=4 SV=1
UniRef50_I1RZ25	62.91%	895	Uncharacterized protein n=52 Tax=leotiomyceta TaxID=716546 RepID=I1RZ25_GIBZE
A0A1E3PDQ2_9ASCO	62.19%	894	Multifunctional beta-oxidation enzyme OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84196 PE=4 SV=1
A0A1D8PJ13_CANAL	49.83%	905	Bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FOX2 PE=4 SV=1
FOX2_YEAST	50.60%	919	Peroxisomal hydratase-dehydrogenase-epimerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOX2 PE=2 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0621

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
5 - 256
NAD(P)-binding domain (IPR016040)
309 - 547
NAD(P)-binding domain (IPR016040)
621 - 761
HotDog domain (IPR029069)
770 - 885
HotDog domain (IPR029069)
MaoC-like domain (IPR002539)

1 100 200 300 400 500 600 700 800 894

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PR00080 (SDRFAMILY)
  
  91 - 102
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  144 - 152
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  457 - 476
  
  PRINTS
  PR00080 (SDRFAMILY)
2. PR00081 (GDHRDH)
  
  457 - 476
  
  PRINTS
  PR00081 (GDHRDH)
  
  431 - 447
  
  PRINTS
  PR00081 (GDHRDH)
  
  384 - 395
  
  PRINTS
  PR00081 (GDHRDH)
  
  478 - 495
  
  PRINTS
  PR00081 (GDHRDH)
  
  315 - 332
  
  PRINTS
  PR00081 (GDHRDH)
3. PF00106 (adh_short)
  
  314 - 499
  
  Pfam
  PF00106 (adh_short)
  
  10 - 195
  
  Pfam
  PF00106 (adh_short)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  309 - 547
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  5 - 256
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR029069

HotDog domain
1. SSF54637 (Thioester...)
  
  771 - 885
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
  
  621 - 761
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
IPR002539

MaoC-like domain
1. PF01575 (MaoC_dehyd...)
  
  770 - 881
  
  Pfam
  PF01575 (MaoC_dehydratas)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  151 - 179
  
  PROSITE patterns
  PS00061 (ADH_SHORT)
  
  444 - 472
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

G3DSA:3.10.12...

768 - 893

GENE3D
G3DSA:3.10.129.10 (G3DSA:3.10.129.10)

618 - 766

GENE3D
G3DSA:3.10.129.10 (G3DSA:3.10.129.10)
G3DSA:3.40.50...

4 - 284

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

285 - 541

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
SM00822 (PKS_KR)

314 - 488

SMART
SM00822 (PKS_KR)
cd03448 (HDE_HSD)

772 - 887

CDD
cd03448 (HDE_HSD)
cd05353 (hydroxyacy...)

5 - 254

CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

310 - 547

CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
mobidb-lite (disord...)

753 - 774

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

homodimer interfac...

5L

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

32R

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

107S

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

108F

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

109K

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

111M

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

112K

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

113D

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

116W

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

117D

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

120Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

124T

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

125Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

128Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

131A

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

132R

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

135W

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

136P

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

152A

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

153A

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

154G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

155L

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

156Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

157G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

158N

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

159F

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

160G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

162T

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

165S

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

166A

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

169L

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

170G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

172V

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

173G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

174F

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

176E

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

177T

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

178L

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

180K

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

181E

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

183Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

184K

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

186N

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

209L

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

212K

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

213L

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

217Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

220P

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

221M

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

223A

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

224Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

225L

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

232E

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

236I

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

237F

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

238E

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

240G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

241A

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

242G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

243F

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

244Y

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

245S

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

246K

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

247V

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

248R

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

249W

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

250E

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

251R

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

252S

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

253S

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

254G

homodimer interface
5L, 32R, 107S, 108F, 109K, 111M, 112K, 113D, 116W, 117D, 120Y, 124T, 125Y, 128Y, 131A, 132R, 135W, 136P, 152A, 153A, 154G, 155L, 156Y, 157G, 158N, 159F, 160G, 162T, 165S, 166A, 169L, 170G, 172V, 173G, 174F, 176E, 177T, 178L, 180K, 181E, 183Y, 184K, 186N, 209L, 212K, 213L, 217Y, 220P, 221M, 223A, 224Y, 225L, 232E, 236I, 237F, 238E, 240G, 241A, 242G, 243F, 244Y, 245S, 246K, 247V, 248R, 249W, 250E, 251R, 252S, 253S, 254G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
NAD binding site c...

16G

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

19G

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

20G

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

21L

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

39N

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

40D

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

41L

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

43S

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

75S

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

76V

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

99N

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

100A

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

101G

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

102I

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

122V

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

123H

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

149T

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

150S

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

151S

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

164Y

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

168K

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

194P

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

195L

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

196A

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

198S

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

199R

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

200L

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

201T

NAD binding site
16G, 19G, 20G, 21L, 39N, 40D, 41L, 43S, 75S, 76V, 99N, 100A, 101G, 102I, 122V, 123H, 149T, 150S, 151S, 164Y, 168K, 194P, 195L, 196A, 198S, 199R, 200L, 201T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
active site cd05353

123H

active site
123H, 151S, 164Y, 168K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

151S

active site
123H, 151S, 164Y, 168K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

164Y

active site
123H, 151S, 164Y, 168K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

168K

active site
123H, 151S, 164Y, 168K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
NAD binding site c...

320G

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

323A

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

324G

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

325I

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

343N

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

344D

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

345F

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

347N

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

368N

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

369V

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

392N

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

393A

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

394G

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

395I

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

415V

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

416H

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

442T

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

443T

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

444S

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

457Y

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

461K

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

487P

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

488N

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

489A

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

491T

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

492A

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

493M

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

494T

NAD binding site
320G, 323A, 324G, 325I, 343N, 344D, 345F, 347N, 368N, 369V, 392N, 393A, 394G, 395I, 415V, 416H, 442T, 443T, 444S, 457Y, 461K, 487P, 488N, 489A, 491T, 492A, 493M, 494T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
homodimer interfac...

336L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

400S

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

401F

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

402A

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

404M

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

405T

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

406D

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

409W

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

410Q

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

413Y

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

417L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

418L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

421Y

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

424T

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

425K

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

428W

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

429P

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

445T

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

446S

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

447G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

448I

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

449Y

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

450G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

451N

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

452F

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

453G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

455A

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

458A

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

459S

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

462A

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

463G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

465L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

466G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

467F

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

469R

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

470A

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

471L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

473Q

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

474E

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

476A

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

477K

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

479N

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

502M

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

505S

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

506F

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

510F

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

513P

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

514L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

516V

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

517L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

518L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

525G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

529L

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

530Y

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

531E

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

533G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

534S

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

535G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

536W

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

537I

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

538G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

539A

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

540T

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

541R

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

542W

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

543Q

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

544R

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

545S

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

546G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

547G

homodimer interface
336L, 400S, 401F, 402A, 404M, 405T, 406D, 409W, 410Q, 413Y, 417L, 418L, 421Y, 424T, 425K, 428W, 429P, 445T, 446S, 447G, 448I, 449Y, 450G, 451N, 452F, 453G, 455A, 458A, 459S, 462A, 463G, 465L, 466G, 467F, 469R, 470A, 471L, 473Q, 474E, 476A, 477K, 479N, 502M, 505S, 506F, 510F, 513P, 514L, 516V, 517L, 518L, 525G, 529L, 530Y, 531E, 533G, 534S, 535G, 536W, 537I, 538G, 539A, 540T, 541R, 542W, 543Q, 544R, 545S, 546G, 547G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
active site cd05353

416H

active site
416H, 444S, 457Y, 461K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

444S

active site
416H, 444S, 457Y, 461K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

457Y

active site
416H, 444S, 457Y, 461K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

461K

active site
416H, 444S, 457Y, 461K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
dimer interaction ...

787D

dimer interaction site
787D, 790A, 793R, 794L, 798L, 800P, 804D
CDD
cd03448 (HDE_HSD)

790A

dimer interaction site
787D, 790A, 793R, 794L, 798L, 800P, 804D
CDD
cd03448 (HDE_HSD)

793R

dimer interaction site
787D, 790A, 793R, 794L, 798L, 800P, 804D
CDD
cd03448 (HDE_HSD)

794L

dimer interaction site
787D, 790A, 793R, 794L, 798L, 800P, 804D
CDD
cd03448 (HDE_HSD)

798L

dimer interaction site
787D, 790A, 793R, 794L, 798L, 800P, 804D
CDD
cd03448 (HDE_HSD)

800P

dimer interaction site
787D, 790A, 793R, 794L, 798L, 800P, 804D
CDD
cd03448 (HDE_HSD)

804D

dimer interaction site
787D, 790A, 793R, 794L, 798L, 800P, 804D
CDD
cd03448 (HDE_HSD)
substrate-binding ...

791Y

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

797D

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

799N

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

802H

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

819H

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

821L

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

824F

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

827S

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

831L

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

838F

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

841I

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

843V

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

845F

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

859T

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

868F

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

870T

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

879A

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)

885V

substrate-binding tunnel
791Y, 797D, 799N, 802H, 819H, 821L, 824F, 827S, 831L, 838F, 841I, 843V, 845F, 859T, 868F, 870T, 879A, 885V
CDD
cd03448 (HDE_HSD)
active site cd03448

792Y

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)

796G

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)

797D

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)

799N

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)

802H

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)

817I

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)

820G

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)

821L

active site
792Y, 796G, 797D, 799N, 802H, 817I, 820G, 821L
CDD
cd03448 (HDE_HSD)
catalytic site cd0...

797D

catalytic site
797D, 799N, 802H, 820G
CDD
cd03448 (HDE_HSD)

799N

catalytic site
797D, 799N, 802H, 820G
CDD
cd03448 (HDE_HSD)

802H

catalytic site
797D, 799N, 802H, 820G
CDD
cd03448 (HDE_HSD)

820G

catalytic site
797D, 799N, 802H, 820G
CDD
cd03448 (HDE_HSD)
substrate binding ...

828G

substrate binding site
828G, 831L, 838F
CDD
cd03448 (HDE_HSD)

831L

substrate binding site
828G, 831L, 838F
CDD
cd03448 (HDE_HSD)

838F

substrate binding site
828G, 831L, 838F
CDD
cd03448 (HDE_HSD)

Protein sequence

>MCA_03518_1
MTNELRYDGKVVVITGAGGGLGKAYALFFASRGASVVVNDLGSSFKGEGANSKAADAVVEQIKKAGGKAVANYDSVENGD
KIIETAVKAFGTVHIVINNAGILRDVSFKNMKDSDWDLIYKVHTYGSYKVARAAWPYFRKQKYGRIVNTSSAAGLYGNFG
QTNYSAAKLGLVGFTETLAKEGYKYNIFANVIAPLAASRLTETIMGPELLEKLSPDYIVPMVAYLSHENTQETGGIFELG
AGFYSKVRWERSSGVVFKTDETFTPSAILKKWNKITDFSNPSYPTGPADFITYAEESAKAPKNEQGEPISFKDQVVIVTG
AGAGIGRAYALLFAKLGAKVVVNDFANPQGVVDEITKAGGTAVADKSNVVEGHKVVETALKAFGTIHVVVNNAGILRDKS
FANMTDDQWQAVYQVHLLGTYAVTKAAWPILLKQKYGRIINTTSTSGIYGNFGQANYASAKAGILGFSRALAQEGAKYNI
FVNTIAPNAGTAMTKSIFTEEMLESFKPEFIAPLVVLLGSNKAPGTGGLYESGSGWIGATRWQRSGGFTVQGPPPPVEVI
AENIDKIVNFDDGRAITVSTFKESSESILGPVLAAAGKSKKNKSSDFTPVDPKDYHKFATESDFSYDFKDSILYNLCVGA
HATDLKYSFEGDDDFQVLPTYGVIPPFSATLDYQSIVPNFNPMTLLHGEQFLEIRKWPVPTEAEVVNITKPLEILDKGKA
AVVITETVTKDKHTGEDIFYNISSTFLRGSGGFGGQTKGADRGPVTASNKPPAREPDYVEQYKIDADKAAYYRLCGDLNP
LHIDPAFAAVGKFPQPILHGLATFGISGKILYEKYGKFKNIKVRFSGHVFPGETVQVETWKEGNKVLFQTRVVERNTIAI
SAAAVELVGKDTKL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component