Protein

MIA_03350_1

Length
536 amino acids


Browser: contig04:961666-963277+

Protein function

EGGNOG:0PFAGFG00490.1Methylmalonate-semialdehyde dehydrogenase
SGD closest match:S000005901ALD4Potassium-activated aldehyde dehydrogenase, mitochondrial
CGD closest match:CAL0000180476ALD6Ald6p

Protein alignments

%idAln lengthE-value
A0A0J9XEP4_GEOCN84.375%5120.0Similar to Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase OS=Geotrichum candidum GN=BN980_GECA11s00219g PE=4 SV=1
MCA_02904_184.302%5160.0MCA_02904_1
A0A161HIF7_9ASCO80.388%5150.0Aldehyde dehydrogenase (NADP(+)) ALD4 OS=Sugiyamaella lignohabitans GN=ALD4 PE=4 SV=1
A0A060T2X7_BLAAD78.252%5150.0ARAD1C36454p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36454g PE=4 SV=1
A0A1E3PFL1_9ASCO74.213%5080.0Methylmalonate-semialdehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83764 PE=4 SV=1
Q6CDB9_YARLI68.932%5150.0YALI0C01859p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C01859g PE=4 SV=1
A0A1E4TLP3_9ASCO69.472%5110.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_90631 PE=4 SV=1
UniRef50_A0A163FN9767.723%5050.0Methylmalonate-semialdehyde dehydrogenase (Acylating) n=1 Tax=Didymella rabiei TaxID=5454 RepID=A0A163FN97_DIDRA
A0A1D8PM94_CANAL62.648%5060.0Ald6p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ALD6 PE=4 SV=1
ALDH4_YEAST30.580%4482.45e-62Potassium-activated aldehyde dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALD4 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9834
Predicted cleavage: 35

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 500 536

Detailed signature matches

    1. cd07085 (ALDH_F6_MMSDH)
    1. SSF53720 (ALDH-like)
    1. PF00171 (Aldedh)
    1. PS00070 (ALDEHYDE_D...)
Unintegrated signatures no IPR
Unintegrated signatures

Residue annotation

  1. tetrameric interfa...
  2. NAD binding site c...
  3. catalytic residues...

Protein sequence

>MIA_03350_1
MNRATRLAQSSRQLTLLSSRMGSTRSLASFVKSHDKIENPPDTPYYTNNAFVNSATDAWIDVHDPATNYLVSRVPQNTPD
ELTAAVDAAQEAFKSFRKTSILSRQQIAFNFVRLIRENWDRLAASITLEQGKTLPDARGDVLRGLQVAETACAVTTQLTG
EFLEVSKDMETKMYREPLGVVAAICPFNFPAMIPLWSIPLTIVTGNTLILKPSERDPGAALILADLARQAGAPPGVINVV
HGAAPTVDFILDEPRIKAISFVGSDKAGKYIYTRGSANGKRVQANLGAKNHAVLLPDANKNFAINSIVGAAFGAAGQRCM
ALSALVAVGPAKHWVADIAALAANLKVSGGFVEGTDVGPVITPQSKKRIIEIIDDAERAGATILLDGRNYSNPDFPNGNF
VGPTIITGVKPGMRAYDEEIFGPVLVVVEVDTLDEAIDLINKNKYGNGSAIFTQSGSTGYKFQKEIEAGQVGINVPIPVP
LPMFSFTGNKGSFLGDLNFYGKAGVYFLTQYKTVTTHWRAEDALATKASVDMPTQS

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.