Protein
MCA_02904_1
Length
540 amino acids
Gene name: ALD4B
Description: Potassium-activated aldehyde dehydrogenase, mitochondrial
Browser: contigB:2701357-2702980-
RNA-seq: read pairs 1834, FPKM 41.9, percentile rank 61.3% (100% = highest expression)
Protein function
| Annotation: | ALD4B | Potassium-activated aldehyde dehydrogenase, mitochondrial | |
|---|---|---|---|
| KEGG: | K00140 | mmsA | malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] |
| EGGNOG: | 0PFAG | FG00490.1 | Methylmalonate-semialdehyde dehydrogenase |
| SGD closest match: | S000005901 | ALD4 | Potassium-activated aldehyde dehydrogenase, mitochondrial |
| CGD closest match: | CAL0000180476 | ALD6 | Ald6p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9XEP4_GEOCN | 81.48% | 540 | 0.0 | Similar to Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase OS=Geotrichum candidum GN=BN980_GECA11s00219g PE=4 SV=1 |
| MIA_03350_1 | 82.28% | 536 | 0.0 | MIA_03350_1 |
| A0A161HIF7_9ASCO | 78.42% | 533 | 0.0 | Aldehyde dehydrogenase (NADP(+)) ALD4 OS=Sugiyamaella lignohabitans GN=ALD4 PE=4 SV=1 |
| A0A060T2X7_BLAAD | 78.10% | 516 | 0.0 | ARAD1C36454p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36454g PE=4 SV=1 |
| A0A1E3PFL1_9ASCO | 72.36% | 521 | 0.0 | Methylmalonate-semialdehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83764 PE=4 SV=1 |
| Q6CDB9_YARLI | 70.53% | 526 | 0.0 | YALI0C01859p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C01859g PE=4 SV=1 |
| A0A1E4TLP3_9ASCO | 69.69% | 518 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_90631 PE=4 SV=1 |
| UniRef50_A0A163FN97 | 65.12% | 539 | 0.0 | Methylmalonate-semialdehyde dehydrogenase (Acylating) n=1 Tax=Didymella rabiei TaxID=5454 RepID=A0A163FN97_DIDRA |
| A0A1D8PM94_CANAL | 60.30% | 539 | 0.0 | Ald6p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ALD6 PE=4 SV=1 |
| ALDH4_YEAST | 31.47% | 448 | 1e-59 | Potassium-activated aldehyde dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALD4 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9983
Predicted cleavage: 39
Protein family membership
- Methylmalonate-semialdehyde dehydrogenase (IPR010061)
Domains and repeats
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Domain
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Domain
1
50
100
150
200
250
300
350
400
450
500
540
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
tetrameric interfa...
-
NAD binding site c...
-
catalytic residues...
Protein sequence
>MCA_02904_1 MASKHLLNVSRRLAMRSPVLPRVYISQMRTITDFIKSHDKIENPSTTKYFINNEALESKTTQWIDVHDPATNNLVSRVPQ STPEELTAAVDAAEAAFKTFKNTSILSRQQIAFNFVKLIRENWDKLAAAITLEQGKTFADAKGDVLRGLQVAESACGITS QLTGEFLEVSKDMETKMYREPLGVVAAIYPFNFPAMIPLWSIPLVIVTGNTLVLKPSERDPGCAVLLAELAKQAGAPPGV INIVHGAAPTVDFILDEPRIKAISFVGSDSAGKYIYTRGTANGKRVQANLGAKNHAVLLPDANKNFALNSIVGAAFGAAG QRCMALSVLVTVGETKEWVSEVAERAKALKVSGGFVEGTDVGPVITPQAKKRIIEIIDDAEKAGATILLDGRNYTNPDFP NGNFVGPTVITGVKPGMRAYDEEIFGPVLVVVEVDTLDDAISLINRNKYGNGTSIFTQNGSTGYRFQKEVEAGQVGINVP IPVPLPMFSFTGNKGSFLGDLNFYGKAGLYFLTQYKTVTTHWRAEDASSSKATVNMPTQS
GO term prediction
Biological Process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0016491 oxidoreductase activity
Cellular Component
None predicted.