Protein
MIA_03299_1
Length
321 amino acids
Browser: contig04:814423-815389-
Protein function
| EGGNOG: | 0PFY7 | MEU1 | Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) |
|---|---|---|---|
| SGD closest match: | S000004007 | MEU1 | S-methyl-5'-thioadenosine phosphorylase |
| CGD closest match: | CAL0000179927 | MEU1 | S-methyl-5'-thioadenosine phosphorylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_02526_1 | 83.280% | 311 | 6.68e-156 | MCA_02526_1 |
| A0A0J9X9N5_GEOCN | 72.115% | 312 | 3.96e-120 | S-methyl-5'-thioadenosine phosphorylase OS=Geotrichum candidum GN=MEU1 PE=3 SV=1 |
| A0A060T7G2_BLAAD | 69.903% | 309 | 2.17e-118 | S-methyl-5'-thioadenosine phosphorylase OS=Blastobotrys adeninivorans GN=MEU1 PE=3 SV=1 |
| A0A1E3PLV6_9ASCO | 68.608% | 309 | 1.32e-115 | S-methyl-5'-thioadenosine phosphorylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=MEU1 PE=3 SV=1 |
| MTAP_YARLI | 67.961% | 309 | 7.85e-115 | S-methyl-5'-thioadenosine phosphorylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MEU1 PE=3 SV=1 |
| UniRef50_Q6CES3 | 67.961% | 309 | 1.82e-111 | S-methyl-5'-thioadenosine phosphorylase n=74 Tax=Fungi TaxID=4751 RepID=MTAP_YARLI |
| A0A167FNK4_9ASCO | 63.057% | 314 | 4.11e-110 | Purine nucleoside phosphorylase OS=Sugiyamaella lignohabitans GN=MEU1 PE=3 SV=1 |
| A0A1E4TEX6_9ASCO | 62.620% | 313 | 1.66e-109 | S-methyl-5'-thioadenosine phosphorylase OS=Tortispora caseinolytica NRRL Y-17796 GN=MEU1 PE=3 SV=1 |
| MTAP_CANAL | 63.950% | 319 | 1.16e-106 | S-methyl-5'-thioadenosine phosphorylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MEU1 PE=3 SV=1 |
| MTAP_YEAST | 53.226% | 310 | 3.83e-74 | S-methyl-5'-thioadenosine phosphorylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MEU1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1993
Predicted cleavage: 12
Protein family membership
- Methylthioadenosine phosphorylase (MTAP) (IPR010044)
Domains and repeats
-
Domain
1
50
100
150
200
250
321
Detailed signature matches
-
-
PS01240 (PNP_MTAP_2)
-
no IPR
Unintegrated signatures
Protein sequence
>MIA_03299_1 MRHIGLIPRYTSSYVEPVLLGVIGGTGLYHMDSLTPVARITVDTPWGKPSSPITISRTTSGFPIAFLARHGYHHEFTPTD VPARANIAAFKKLGVRVIVAFSAVGSLQEKIRPRDFVVPNQIIDRTKGLRPSSFFGTGFVGHVGFGEPFDVELNKVISSF AKSSTPVLNNGALLHTKETNDNKDVVLICMEGPAFSTRAESVLYRSWNGSVINMSALPEAKLAKEAEIAYQMICMSTDYD AWREDEEPVTVETVVGNLKANGENANKFITALIPKLEEEIKAEKLGVSLKGSIKYSVSTSHGGIDPTLKANLNWLHPGYW E
GO term prediction
Biological Process
GO:0009116 nucleoside metabolic process
Molecular Function
GO:0003824 catalytic activity
GO:0016763 transferase activity, transferring pentosyl groups
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
Cellular Component
None predicted.