Protein
MCA_02526_1
Length
313 amino acids
Gene name: MEU1
Description: S-methyl-5'-thioadenosine phosphorylase
Browser: contigB:1561734-1562923-
RNA-seq: read pairs 4890, FPKM 192.4, percentile rank 87.7% (100% = highest expression)
Protein function
| Annotation: | MEU1 | S-methyl-5'-thioadenosine phosphorylase | |
|---|---|---|---|
| KEGG: | K00772 | mtaP | 5'-methylthioadenosine phosphorylase [EC:2.4.2.28] |
| EGGNOG: | 0PFY7 | MEU1 | Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) |
| SGD closest match: | S000004007 | MEU1 | S-methyl-5'-thioadenosine phosphorylase |
| CGD closest match: | CAL0000179927 | MEU1 | S-methyl-5'-thioadenosine phosphorylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03299_1 | 83.28% | 311 | 1e-176 | MIA_03299_1 |
| A0A060T7G2_BLAAD | 72.35% | 311 | 2e-146 | S-methyl-5'-thioadenosine phosphorylase OS=Blastobotrys adeninivorans GN=MEU1 PE=3 SV=1 |
| A0A0J9X9N5_GEOCN | 70.16% | 315 | 2e-140 | S-methyl-5'-thioadenosine phosphorylase OS=Geotrichum candidum GN=MEU1 PE=3 SV=1 |
| MTAP_YARLI | 69.68% | 310 | 2e-139 | S-methyl-5'-thioadenosine phosphorylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MEU1 PE=3 SV=1 |
| UniRef50_Q6CES3 | 69.68% | 310 | 6e-136 | S-methyl-5'-thioadenosine phosphorylase n=74 Tax=Fungi TaxID=4751 RepID=MTAP_YARLI |
| A0A1E3PLV6_9ASCO | 66.99% | 309 | 3e-136 | S-methyl-5'-thioadenosine phosphorylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=MEU1 PE=3 SV=1 |
| A0A1E4TEX6_9ASCO | 63.29% | 316 | 3e-133 | S-methyl-5'-thioadenosine phosphorylase OS=Tortispora caseinolytica NRRL Y-17796 GN=MEU1 PE=3 SV=1 |
| MTAP_CANAL | 64.91% | 322 | 2e-132 | S-methyl-5'-thioadenosine phosphorylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MEU1 PE=3 SV=1 |
| A0A167FNK4_9ASCO | 62.86% | 315 | 1e-128 | Purine nucleoside phosphorylase OS=Sugiyamaella lignohabitans GN=MEU1 PE=3 SV=1 |
| MTAP_YEAST | 52.04% | 319 | 5e-96 | S-methyl-5'-thioadenosine phosphorylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MEU1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0554
Protein family membership
- Methylthioadenosine phosphorylase (MTAP) (IPR010044)
Domains and repeats
-
Domain
1
50
100
150
200
250
313
Detailed signature matches
-
-
PS01240 (PNP_MTAP_2)
-
no IPR
Unintegrated signatures
Protein sequence
>MCA_02526_1 MSDLPNTFDEPVTLGIIGGTGLYHMDSLTPVARITMDTPWGKPSSPITISKTSTGFPIAFLARHGYHHQYTPTDVPSRAN IAAFKKLGVKAIVAFSAVGSLQEKIRPRDFVIPNQIIDRTKGLRPSSFFESGFVGHVGFGEPFDVELNKLLSTFGESALK NGSLLHTKYNNEDKKDVVLICMEGPAFSTRAESHLYRSWNGAVINMSALPESKLAKEAEIAYQMVCMSTDYDAWREDEEP VTVETVVGNLKANGENANNFICALIPKLEEELKAGKIGEAIAGSMKFAVSTSHGGINPTLKEKLNWLHPGYWE
GO term prediction
Biological Process
GO:0009116 nucleoside metabolic process
Molecular Function
GO:0003824 catalytic activity
GO:0016763 transferase activity, transferring pentosyl groups
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
Cellular Component
None predicted.