MIA_03274_1

Protein

Length

1,562 amino acids

Protein function

EGGNOG:	0PG20	ARO1	The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (By similarity)
SGD closest match:	S000002534	ARO1	Pentafunctional AROM polypeptide
CGD closest match:	CAL0000177892	ARO1	Pentafunctional AROM polypeptide

Protein alignments

	%id	Aln length
MCA_03457_1	70.836%	1591	MCA_03457_1
A0A0J9XAT5_GEOCN	67.875%	1572	Pentafunctional AROM polypeptide OS=Geotrichum candidum GN=ARO1 PE=3 SV=1
A0A060T792_BLAAD	60.369%	1572	Pentafunctional AROM polypeptide OS=Blastobotrys adeninivorans GN=ARO1 PE=3 SV=1
A0A1E3PQF0_9ASCO	58.455%	1579	Pentafunctional AROM polypeptide OS=Nadsonia fulvescens var. elongata DSM 6958 GN=ARO1 PE=3 SV=1
A0A167F671_9ASCO	62.733%	1339	3-phosphoshikimate 1-carboxyvinyltransferase OS=Sugiyamaella lignohabitans GN=ARO1 PE=3 SV=1
ARO1_YARLI	55.499%	1573	Pentafunctional AROM polypeptide OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ARO1 PE=3 SV=1
ARO1_YEAST	52.185%	1602	Pentafunctional AROM polypeptide OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO1 PE=1 SV=1
UniRef50_P08566	52.185%	1602	Pentafunctional AROM polypeptide n=204 Tax=Ascomycota TaxID=4890 RepID=ARO1_YEAST
ARO1_CANAL	53.792%	1569	Pentafunctional AROM polypeptide OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARO1 PE=3 SV=2
A0A1E4TJD1_9ASCO	52.221%	1576	Pentafunctional AROM polypeptide OS=Tortispora caseinolytica NRRL Y-17796 GN=ARO1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1004

Protein family membership

Pentafunctional AroM protein (IPR008289)

3-phosphoshikimate 1-carboxyvinyltransferase (IPR006264)

Shikimate kinase/gluconokinase (IPR031322)
- Shikimate kinase/Threonine synthase-like 1 (IPR000623)

3-dehydroquinate dehydratase type I (IPR001381)

Domains and repeats

Domain
6 - 391
3-dehydroquinate synthase domain (IPR030960)
3-dehydroquinate synthase AroB (IPR016037)
402 - 839
RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (IPR013792)
Enolpyruvate transferase domain (IPR001986)
861 - 1,013
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,039 - 1,271
Aldolase-type TIM barrel (IPR013785)
1,279 - 1,361
Shikimate dehydrogenase substrate binding, N-terminal (IPR013708)
1,375 - 1,559
NAD(P)-binding domain (IPR016040)
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase (IPR006151)
Domain
1,270 - 1,559
Shikimate dehydrogenase, AroM-type (IPR010110)

1 200 400 600 800 1000 1200 1400 1562

Detailed signature matches

IPR008289

Pentafunctional AroM protein
1. MF_03143 (Pentafunc...)
  
  3 - 1,562
  
  HAMAP
  MF_03143 (Pentafunct_AroM)
2. PIRSF000514 (Pentaf...)
  
  2 - 1,562
  
  PIRSF
  PIRSF000514 (Pentafunct_AroM)
IPR006264

3-phosphoshikimate 1-carboxyvinyltransferase
1. cd01556 (EPSP_synthase)
  
  406 - 835
  
  CDD
  cd01556 (EPSP_synthase)
2. TIGR01356
  
  407 - 837
  
  TIGRFAMs
  TIGR01356 (TIGR01356)
3. MF_00210 (EPSP_synth)
  
  401 - 838
  
  HAMAP
  MF_00210 (EPSP_synth)
IPR031322

Shikimate kinase/gluconokinase
1. PF01202 (SKI)
  
  869 - 1,021
  
  Pfam
  PF01202 (SKI)
IPR000623

Shikimate kinase/Threonine synthase-like 1
1. MF_00109 (Shikimate...)
  
  860 - 1,027
  
  HAMAP
  MF_00109 (Shikimate_kinase)
2. cd00464 (SK)
  
  862 - 1,006
  
  CDD
  cd00464 (SK)
IPR001381

3-dehydroquinate dehydratase type I
1. TIGR01093
  
  1,048 - 1,264
  
  TIGRFAMs
  TIGR01093 (TIGR01093)
2. cd00502 (DHQase_I)
  
  1,047 - 1,266
  
  CDD
  cd00502 (DHQase_I)
3. PF01487 (DHquinase_I)
  
  1,049 - 1,265
  
  Pfam
  PF01487 (DHquinase_I)
IPR030960

3-dehydroquinate synthase domain
1. PF01761 (DHQ_synthase)
  
  76 - 356
  
  Pfam
  PF01761 (DHQ_synthase)
IPR016037

3-dehydroquinate synthase AroB
1. MF_00110 (DHQ_synthase)
  
  6 - 391
  
  HAMAP
  MF_00110 (DHQ_synthase)
2. TIGR01357
  
  15 - 384
  
  TIGRFAMs
  TIGR01357 (TIGR01357)
IPR013792

RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
1. SSF55205 (EPT/RTPC-...)
  
  402 - 835
  
  SUPERFAMILY
  SSF55205 (EPT/RTPC-like)
IPR001986

Enolpyruvate transferase domain
1. G3DSA:3.65.10.10
  
  413 - 627
  
  GENE3D
  G3DSA:3.65.10.10 (G3DSA:3.65.10.10)
  
  628 - 839
  
  GENE3D
  G3DSA:3.65.10.10 (G3DSA:3.65.10.10)
2. PF00275 (EPSP_synthase)
  
  406 - 832
  
  Pfam
  PF00275 (EPSP_synthase)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  861 - 1,013
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR013785

Aldolase-type TIM barrel
1. G3DSA:3.20.20.70
  
  1,039 - 1,271
  
  GENE3D
  G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
IPR010110

Shikimate dehydrogenase, AroM-type
1. TIGR01809
  
  1,270 - 1,559
  
  TIGRFAMs
  TIGR01809 (TIGR01809)
IPR013708

Shikimate dehydrogenase substrate binding, N-terminal
1. PF08501 (Shikimate_...)
  
  1,279 - 1,361
  
  Pfam
  PF08501 (Shikimate_dh_N)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  1,375 - 1,559
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006151

Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
1. PF01488 (Shikimate_DH)
  
  1,401 - 1,477
  
  Pfam
  PF01488 (Shikimate_DH)
IPR023193

3-phosphoshikimate 1-carboxyvinyltransferase, conserved site
1. PS00104 (EPSP_SYNTH...)
  
  481 - 495
  
  PROSITE patterns
  PS00104 (EPSP_SYNTHASE_1)
2. PS00885 (EPSP_SYNTH...)
  
  745 - 763
  
  PROSITE patterns
  PS00885 (EPSP_SYNTHASE_2)
IPR018508

3-dehydroquinate dehydratase, active site
1. PS01028 (DEHYDROQUI...)
  
  1,140 - 1,168
  
  PROSITE patterns
  PS01028 (DEHYDROQUINASE_I)

no IPR

Unintegrated signatures

G3DSA:1.20.10...

182 - 389

GENE3D
G3DSA:1.20.1090.10 (G3DSA:1.20.1090.10)
G3DSA:3.40.50...

1,272 - 1,386

GENE3D
G3DSA:3.40.50.10860 (G3DSA:3.40.50.10860)
G3DSA:3.40.50...

2 - 181

GENE3D
G3DSA:3.40.50.1970 (G3DSA:3.40.50.1970)
G3DSA:3.40.50...

844 - 1,011

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
G3DSA:3.40.50...

1,387 - 1,562

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PR01100 (SHIKIMTKNASE)

863 - 878

PRINTS
PR01100 (SHIKIMTKNASE)

887 - 900

PRINTS
PR01100 (SHIKIMTKNASE)

935 - 944

PRINTS
PR01100 (SHIKIMTKNASE)

960 - 977

PRINTS
PR01100 (SHIKIMTKNASE)

915 - 923

PRINTS
PR01100 (SHIKIMTKNASE)
SSF51569 (Aldolase)

1,041 - 1,270

SUPERFAMILY
SSF51569 (Aldolase)
SSF53223 (Aminoacid...)

1,273 - 1,374

SUPERFAMILY
SSF53223 (Aminoacid dehydrogenase-like, N-terminal domain)
SSF56796 (Dehydroqu...)

10 - 388

SUPERFAMILY
SSF56796 (Dehydroquinate synthase-like)
TMhelix

106 - 128

TMHMM
TMhelix (TMhelix)
cd01065 (NAD_bind_S...)

1,374 - 1,547

CDD
cd01065 (NAD_bind_Shikimate_DH)
cd08195 (DHQS)

15 - 389

CDD
cd08195 (DHQS)

Residue annotation

active site cd08195

44D

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

113G

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

114G

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

115V

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

118D

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

121G

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

138T

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

139T

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

141L

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

160K

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

163I

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

178F

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

186E

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

193E

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

197T

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

269H

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

273H

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)

285H

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 269H, 273H, 285H
CDD
cd08195 (DHQS)
dimer interface cd...

87R

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

94E

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

95D

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

122Y

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

125A

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

127F

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

128M

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

129R

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

151K

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

152T

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

161N

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

162L

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

163I

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

164G

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

165A

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

166F

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)
metal binding site...

193E

metal binding site
193E, 269H, 285H
CDD
cd08195 (DHQS)

269H

metal binding site
193E, 269H, 285H
CDD
cd08195 (DHQS)

285H

metal binding site
193E, 269H, 285H
CDD
cd08195 (DHQS)
hinge cd01556

409P

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)

410P

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)

411G

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)

412S

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)

637I

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)

638E

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)

639S

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)

640D

hinge
409P, 410P, 411G, 412S, 637I, 638E, 639S, 640D
CDD
cd01556 (EPSP_synthase)
active site cd01556

413K

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

414S

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

418R

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

485N

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

487G

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

488T

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

520R

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

567S

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

568S

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

569Q

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

596S

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

599Y

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

716D

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

743N

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

747K

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

748E

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

751R

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

796H

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

797R

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)

823K

active site
413K, 414S, 418R, 485N, 487G, 488T, 520R, 567S, 568S, 569Q, 596S, 599Y, 716D, 743N, 747K, 748E, 751R, 796H, 797R, 823K
CDD
cd01556 (EPSP_synthase)
ADP binding site c...

870G

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)

871A

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)

872G

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)

873K

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)

874T

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)

875F

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)

975Y

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)

982R

ADP binding site
870G, 871A, 872G, 873K, 874T, 875F, 975Y, 982R
CDD
cd00464 (SK)
magnesium binding ...

874T

magnesium binding site
874T, 890D, 892D
CDD
cd00464 (SK)

890D

magnesium binding site
874T, 890D, 892D
CDD
cd00464 (SK)

892D

magnesium binding site
874T, 890D, 892D
CDD
cd00464 (SK)
putative shikimate...

892D

putative shikimate binding site
892D, 916R, 919E, 939G, 940G, 941G, 996R
CDD
cd00464 (SK)

916R

putative shikimate binding site
892D, 916R, 919E, 939G, 940G, 941G, 996R
CDD
cd00464 (SK)

919E

putative shikimate binding site
892D, 916R, 919E, 939G, 940G, 941G, 996R
CDD
cd00464 (SK)

939G

putative shikimate binding site
892D, 916R, 919E, 939G, 940G, 941G, 996R
CDD
cd00464 (SK)

940G

putative shikimate binding site
892D, 916R, 919E, 939G, 940G, 941G, 996R
CDD
cd00464 (SK)

941G

putative shikimate binding site
892D, 916R, 919E, 939G, 940G, 941G, 996R
CDD
cd00464 (SK)

996R

putative shikimate binding site
892D, 916R, 919E, 939G, 940G, 941G, 996R
CDD
cd00464 (SK)
active site cd00502

1,051C

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,074E

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,076R

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,108R

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,167H

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,195K

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,234R

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,252A

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,253A

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)

1,256Q

active site
1,051C, 1,074E, 1,076R, 1,108R, 1,167H, 1,195K, 1,234R, 1,252A, 1,253A, 1,256Q
CDD
cd00502 (DHQase_I)
catalytic residue ...

1,195K

catalytic residue
1,195K
CDD
cd00502 (DHQase_I)
dimer interface cd...

1,207I

dimer interface
1,207I, 1,211Q, 1,235V, 1,236L, 1,240L, 1,261E, 1,265A
CDD
cd00502 (DHQase_I)

1,211Q

dimer interface
1,207I, 1,211Q, 1,235V, 1,236L, 1,240L, 1,261E, 1,265A
CDD
cd00502 (DHQase_I)

1,235V

dimer interface
1,207I, 1,211Q, 1,235V, 1,236L, 1,240L, 1,261E, 1,265A
CDD
cd00502 (DHQase_I)

1,236L

dimer interface
1,207I, 1,211Q, 1,235V, 1,236L, 1,240L, 1,261E, 1,265A
CDD
cd00502 (DHQase_I)

1,240L

dimer interface
1,207I, 1,211Q, 1,235V, 1,236L, 1,240L, 1,261E, 1,265A
CDD
cd00502 (DHQase_I)

1,261E

dimer interface
1,207I, 1,211Q, 1,235V, 1,236L, 1,240L, 1,261E, 1,265A
CDD
cd00502 (DHQase_I)

1,265A

dimer interface
1,207I, 1,211Q, 1,235V, 1,236L, 1,240L, 1,261E, 1,265A
CDD
cd00502 (DHQase_I)
shikimate binding ...

1,375D

shikimate binding site
1,375D, 1,509Y, 1,534L, 1,537Q
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,509Y

shikimate binding site
1,375D, 1,509Y, 1,534L, 1,537Q
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,534L

shikimate binding site
1,375D, 1,509Y, 1,534L, 1,537Q
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,537Q

shikimate binding site
1,375D, 1,509Y, 1,534L, 1,537Q
CDD
cd01065 (NAD_bind_Shikimate_DH)
NAD(P) binding sit...

1,405A

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,408T

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,428N

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,429R

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,469C

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,470V

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,471P

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,507V

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,530G

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,533M

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,534L

NAD(P) binding site
1,405A, 1,408T, 1,428N, 1,429R, 1,469C, 1,470V, 1,471P, 1,507V, 1,530G, 1,533M, 1,534L
CDD
cd01065 (NAD_bind_Shikimate_DH)

Protein sequence

>MIA_03274_1
MTSEITKISILGTESIHIGYHFSSHIVSTVLKELKSTTYVLISDDNIFKFGHVQRLEAEFAQAIKDSNSSSRLLKYIIPP
GESSKNRTTKAEIEDFLLKERCTRDTVILAIGGGVIGDMIGYVAATFMRGVRFVQIPTTLLAMVDSSIGGKTAVDTPLGK
NLIGAFWQPKFIFMDLTFLETLPEREFINGLAEVIKTAAMWDEEKFIELENNNEILLKYIKQRKNGRVDLEPIIEIVRKI
VYGSASIKAEVVTLDEREGGLRNLLNFGHTIGHAYEAILTPHILHGECVSIGMVFEAEVARFLGHLSDGAVARLSKCLAA
YELPITPNDAIVRRRSRNIATPVDQLLDIMNVDKKNDGNVKKIVMLTRIGKTLEKQATKVSDDVIRTVLSESFLVGSFKN
APESVSVIPPGSKSISNRALVLASLGEGVCRISNLLHSDDTEHMLNAVQILGGTKVNWENHGEILVVEGNGGKFKAPSCE
IYLGNAGTASRFLTTVATLVQPSSEADHVVLTGNARMKQRPIGPLVDSLRENGSEVEYQESTGSLPLKIKAGLGFKGGLI
ELKATVSSQYVSSILMCAPYAESPVTLSLVGGKPISQLYIDMTIAMMETFGVKVTKGEGHVYHIPKATYKNPAEYVIESD
ASSATYPLAFAAISGTSVTIPNIGSSSLQGDARFAVDVLRPMGCEVVQTATSTTVTGPPVNGLKSIPMIDMEPMTDAFLT
AAVLAAVAKDGENKTTRIYGIANQRVKECNRIDAMIHELAKFGVTTREHADGLEIDGVDIAKLTVPKGGVSTYDDHRVAM
SFSLLASALPEPVLIKERRCVEKTWPGWWDILNRVFKVGLEAYEDSVAQAQEHRRTPNEDKTIVVVGMRGAGKTFMGRWV
ANSLGLKFVDLDQYLEAKLEKSIPEIIKESGWEGFRKEELTVLREFLEKHPRGWVAACGGGIVETPEARTILKDYMASGR
IVLHVHRNIENIVSYLEVDKTRPAYTSDIFSVWKRREQWYFECSNYFYFASNFSNSSESASVHRSLDLFLKTITGTRGLS
DVPKGRSAFVCLTFDDVREFTGIKESLEGSSAVELRVDLLKDWSLEYVAEQIGYIRLNTDLPIIFTVRTKSQGGKFPDNG
EEEAEKLIRLAYKLGVEYVDLELTWSVGFVDNLVKDKGYSKVIASHHDISGKHGWTSAVWEDYYQRALAVGDVVKFVGTA
KSLQDNIALEQFRAVHTRKPFVAINMGEAGKLSRVLNEVLTPVTHESFPVAAAPGQLTVREINGALAAIGGLPAKEFFVC
GGPAAQSKSPALHNALYKALNLPHKYTYLATESAEEVFAKIGELGDKFGGASVTIPLKLAVLPFLSELTPAAKAIGAVNT
IIPLGGGKFKGDNTDWIGIVKSFEAIGLSSSGKKAGDVAGVVIGAGGTSRAAIEALHALGYQTIYLANRTEASAREVAGA
FSPEYGVQVIVDEEEFKASGKRAEAVVSCVPASAPLDEKLARLVDGVLSGVVALGGGSNTGRYFLDVAYMPVVTPLAEKA
KAQGYATIGGRDMLVYQGVAQFDEWTGQAGPVGAAMTAVYQE

GO term prediction

Biological Process

GO:0009073 aromatic amino acid family biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0003855 3-dehydroquinate dehydratase activity
GO:0003856 3-dehydroquinate synthase activity
GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0004765 shikimate kinase activity
GO:0005524 ATP binding
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features