MCA_03457_1

Protein

Length

1,590 amino acids

Gene name: ARO1B

Description: Pentafunctional AROM polypeptide

Browser: contigC:26583-31456-

RNA-seq: read pairs 6342, FPKM 49.3, percentile rank 65.1% (100% = highest expression)

Protein function

Annotation:		ARO1B	Pentafunctional AROM polypeptide
KEGG:	K13830	ARO1	pentafunctional AROM polypeptide [EC:4.2.3.4 4.2.1.10 1.1.1.25 2.7.1.71 2.5.1.19]
EGGNOG:	0PG20	ARO1	The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (By similarity)
SGD closest match:	S000002534	ARO1	Pentafunctional AROM polypeptide
CGD closest match:	CAL0000177892	ARO1	Pentafunctional AROM polypeptide

Protein alignments

	%id	Aln length
MIA_03274_1	71.29%	1595	MIA_03274_1
A0A0J9XAT5_GEOCN	66.04%	1593	Pentafunctional AROM polypeptide OS=Geotrichum candidum GN=ARO1 PE=3 SV=1
A0A060T792_BLAAD	62.84%	1593	Pentafunctional AROM polypeptide OS=Blastobotrys adeninivorans GN=ARO1 PE=3 SV=1
A0A1E3PQF0_9ASCO	55.67%	1595	Pentafunctional AROM polypeptide OS=Nadsonia fulvescens var. elongata DSM 6958 GN=ARO1 PE=3 SV=1
A0A167F671_9ASCO	61.82%	1354	3-phosphoshikimate 1-carboxyvinyltransferase OS=Sugiyamaella lignohabitans GN=ARO1 PE=3 SV=1
ARO1_YARLI	55.00%	1591	Pentafunctional AROM polypeptide OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ARO1 PE=3 SV=1
UniRef50_A0A093ZYW5	53.23%	1593	Pentafunctional AROM polypeptide n=2 Tax=Pseudogymnoascus TaxID=78156 RepID=A0A093ZYW5_9PEZI
ARO1_CANAL	51.47%	1595	Pentafunctional AROM polypeptide OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARO1 PE=3 SV=2
A0A1E4TJD1_9ASCO	52.44%	1596	Pentafunctional AROM polypeptide OS=Tortispora caseinolytica NRRL Y-17796 GN=ARO1 PE=3 SV=1
ARO1_YEAST	50.68%	1626	Pentafunctional AROM polypeptide OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0787

Protein family membership

Pentafunctional AroM protein (IPR008289)

3-phosphoshikimate 1-carboxyvinyltransferase (IPR006264)

Shikimate kinase/gluconokinase (IPR031322)
- Shikimate kinase/Threonine synthase-like 1 (IPR000623)

3-dehydroquinate dehydratase type I (IPR001381)

Domains and repeats

Domain
6 - 392
3-dehydroquinate synthase domain (IPR030960)
3-dehydroquinate synthase AroB (IPR016037)
404 - 839
RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (IPR013792)
Enolpyruvate transferase domain (IPR001986)
870 - 1,018
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,294 - 1,586
Shikimate dehydrogenase, AroM-type (IPR010110)
Domain
1,047 - 1,295
Aldolase-type TIM barrel (IPR013785)
1,303 - 1,385
Shikimate dehydrogenase substrate binding, N-terminal (IPR013708)
1,399 - 1,587
NAD(P)-binding domain (IPR016040)
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase (IPR006151)

1 200 400 600 800 1000 1200 1400 1590

Detailed signature matches

IPR008289

Pentafunctional AroM protein
1. MF_03143 (Pentafunc...)
  
  3 - 1,589
  
  HAMAP
  MF_03143 (Pentafunct_AroM)
2. PIRSF000514 (Pentaf...)
  
  2 - 1,590
  
  PIRSF
  PIRSF000514 (Pentafunct_AroM)
IPR006264

3-phosphoshikimate 1-carboxyvinyltransferase
1. cd01556 (EPSP_synthase)
  
  408 - 839
  
  CDD
  cd01556 (EPSP_synthase)
2. TIGR01356
  
  408 - 839
  
  TIGRFAMs
  TIGR01356 (TIGR01356)
3. MF_00210 (EPSP_synth)
  
  403 - 843
  
  HAMAP
  MF_00210 (EPSP_synth)
IPR031322

Shikimate kinase/gluconokinase
1. PF01202 (SKI)
  
  878 - 1,020
  
  Pfam
  PF01202 (SKI)
IPR000623

Shikimate kinase/Threonine synthase-like 1
1. MF_00109 (Shikimate...)
  
  869 - 1,041
  
  HAMAP
  MF_00109 (Shikimate_kinase)
2. cd00464 (SK)
  
  871 - 1,016
  
  CDD
  cd00464 (SK)
IPR001381

3-dehydroquinate dehydratase type I
1. TIGR01093
  
  1,061 - 1,289
  
  TIGRFAMs
  TIGR01093 (TIGR01093)
2. cd00502 (DHQase_I)
  
  1,060 - 1,292
  
  CDD
  cd00502 (DHQase_I)
3. PF01487 (DHquinase_I)
  
  1,063 - 1,290
  
  Pfam
  PF01487 (DHquinase_I)
IPR030960

3-dehydroquinate synthase domain
1. PF01761 (DHQ_synthase)
  
  76 - 357
  
  Pfam
  PF01761 (DHQ_synthase)
IPR016037

3-dehydroquinate synthase AroB
1. MF_00110 (DHQ_synthase)
  
  6 - 392
  
  HAMAP
  MF_00110 (DHQ_synthase)
2. TIGR01357
  
  15 - 384
  
  TIGRFAMs
  TIGR01357 (TIGR01357)
IPR013792

RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
1. SSF55205 (EPT/RTPC-...)
  
  404 - 839
  
  SUPERFAMILY
  SSF55205 (EPT/RTPC-like)
IPR001986

Enolpyruvate transferase domain
1. G3DSA:3.65.10.10
  
  415 - 633
  
  GENE3D
  G3DSA:3.65.10.10 (G3DSA:3.65.10.10)
  
  634 - 839
  
  GENE3D
  G3DSA:3.65.10.10 (G3DSA:3.65.10.10)
2. PF00275 (EPSP_synthase)
  
  406 - 837
  
  Pfam
  PF00275 (EPSP_synthase)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  870 - 1,018
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR013785

Aldolase-type TIM barrel
1. G3DSA:3.20.20.70
  
  1,047 - 1,295
  
  GENE3D
  G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
IPR010110

Shikimate dehydrogenase, AroM-type
1. TIGR01809
  
  1,294 - 1,586
  
  TIGRFAMs
  TIGR01809 (TIGR01809)
IPR013708

Shikimate dehydrogenase substrate binding, N-terminal
1. PF08501 (Shikimate_...)
  
  1,303 - 1,385
  
  Pfam
  PF08501 (Shikimate_dh_N)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  1,399 - 1,587
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006151

Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
1. PF01488 (Shikimate_DH)
  
  1,420 - 1,512
  
  Pfam
  PF01488 (Shikimate_DH)
IPR023193

3-phosphoshikimate 1-carboxyvinyltransferase, conserved site
1. PS00104 (EPSP_SYNTH...)
  
  483 - 497
  
  PROSITE patterns
  PS00104 (EPSP_SYNTHASE_1)
2. PS00885 (EPSP_SYNTH...)
  
  750 - 768
  
  PROSITE patterns
  PS00885 (EPSP_SYNTHASE_2)
IPR018508

3-dehydroquinate dehydratase, active site
1. PS01028 (DEHYDROQUI...)
  
  1,160 - 1,188
  
  PROSITE patterns
  PS01028 (DEHYDROQUINASE_I)

no IPR

Unintegrated signatures

G3DSA:1.20.10...

182 - 390

GENE3D
G3DSA:1.20.1090.10 (G3DSA:1.20.1090.10)
G3DSA:3.40.50...

1,296 - 1,411

GENE3D
G3DSA:3.40.50.10860 (G3DSA:3.40.50.10860)
G3DSA:3.40.50...

2 - 181

GENE3D
G3DSA:3.40.50.1970 (G3DSA:3.40.50.1970)
G3DSA:3.40.50...

870 - 1,039

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
G3DSA:3.40.50...

1,412 - 1,590

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PR01100 (SHIKIMTKNASE)

944 - 953

PRINTS
PR01100 (SHIKIMTKNASE)

969 - 986

PRINTS
PR01100 (SHIKIMTKNASE)

872 - 887

PRINTS
PR01100 (SHIKIMTKNASE)

896 - 909

PRINTS
PR01100 (SHIKIMTKNASE)

924 - 932

PRINTS
PR01100 (SHIKIMTKNASE)
SSF51569 (Aldolase)

1,055 - 1,294

SUPERFAMILY
SSF51569 (Aldolase)
SSF53223 (Aminoacid...)

1,297 - 1,398

SUPERFAMILY
SSF53223 (Aminoacid dehydrogenase-like, N-terminal domain)
SSF56796 (Dehydroqu...)

10 - 375

SUPERFAMILY
SSF56796 (Dehydroquinate synthase-like)
TMhelix

106 - 128

TMHMM
TMhelix (TMhelix)
cd01065 (NAD_bind_S...)

1,398 - 1,573

CDD
cd01065 (NAD_bind_Shikimate_DH)
cd08195 (DHQS)

15 - 390

CDD
cd08195 (DHQS)

Residue annotation

active site cd08195

44D

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

113G

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

114G

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

115V

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

118D

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

121G

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

138T

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

139T

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

141L

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

160K

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

163I

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

178F

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

186E

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

193E

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

197T

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

270H

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

274H

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)

286H

active site
44D, 113G, 114G, 115V, 118D, 121G, 138T, 139T, 141L, 160K, 163I, 178F, 186E, 193E, 197T, 270H, 274H, 286H
CDD
cd08195 (DHQS)
dimer interface cd...

87R

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

94E

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

95D

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

122Y

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

125A

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

127F

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

128M

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

129R

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

151K

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

152T

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

161N

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

162L

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

163I

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

164G

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

165A

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)

166F

dimer interface
87R, 94E, 95D, 122Y, 125A, 127F, 128M, 129R, 151K, 152T, 161N, 162L, 163I, 164G, 165A, 166F
CDD
cd08195 (DHQS)
metal binding site...

193E

metal binding site
193E, 270H, 286H
CDD
cd08195 (DHQS)

270H

metal binding site
193E, 270H, 286H
CDD
cd08195 (DHQS)

286H

metal binding site
193E, 270H, 286H
CDD
cd08195 (DHQS)
hinge cd01556

411P

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)

412P

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)

413G

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)

414S

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)

641I

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)

642E

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)

643S

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)

644D

hinge
411P, 412P, 413G, 414S, 641I, 642E, 643S, 644D
CDD
cd01556 (EPSP_synthase)
active site cd01556

415K

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

416S

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

420R

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

487N

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

489G

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

490T

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

522R

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

569S

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

570S

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

571Q

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

598S

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

601Y

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

720D

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

748N

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

752K

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

753E

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

756R

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

801H

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

802R

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)

828K

active site
415K, 416S, 420R, 487N, 489G, 490T, 522R, 569S, 570S, 571Q, 598S, 601Y, 720D, 748N, 752K, 753E, 756R, 801H, 802R, 828K
CDD
cd01556 (EPSP_synthase)
ADP binding site c...

879G

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)

880A

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)

881G

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)

882K

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)

883T

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)

884S

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)

984Y

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)

991R

ADP binding site
879G, 880A, 881G, 882K, 883T, 884S, 984Y, 991R
CDD
cd00464 (SK)
magnesium binding ...

883T

magnesium binding site
883T, 899D, 901D
CDD
cd00464 (SK)

899D

magnesium binding site
883T, 899D, 901D
CDD
cd00464 (SK)

901D

magnesium binding site
883T, 899D, 901D
CDD
cd00464 (SK)
putative shikimate...

901D

putative shikimate binding site
901D, 925R, 928E, 948G, 949G, 950G, 1,005R
CDD
cd00464 (SK)

925R

putative shikimate binding site
901D, 925R, 928E, 948G, 949G, 950G, 1,005R
CDD
cd00464 (SK)

928E

putative shikimate binding site
901D, 925R, 928E, 948G, 949G, 950G, 1,005R
CDD
cd00464 (SK)

948G

putative shikimate binding site
901D, 925R, 928E, 948G, 949G, 950G, 1,005R
CDD
cd00464 (SK)

949G

putative shikimate binding site
901D, 925R, 928E, 948G, 949G, 950G, 1,005R
CDD
cd00464 (SK)

950G

putative shikimate binding site
901D, 925R, 928E, 948G, 949G, 950G, 1,005R
CDD
cd00464 (SK)

1,005R

putative shikimate binding site
901D, 925R, 928E, 948G, 949G, 950G, 1,005R
CDD
cd00464 (SK)
active site cd00502

1,064C

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,087E

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,089R

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,128R

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,187H

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,218K

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,258R

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,276A

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,277A

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)

1,280Q

active site
1,064C, 1,087E, 1,089R, 1,128R, 1,187H, 1,218K, 1,258R, 1,276A, 1,277A, 1,280Q
CDD
cd00502 (DHQase_I)
catalytic residue ...

1,218K

catalytic residue
1,218K
CDD
cd00502 (DHQase_I)
dimer interface cd...

1,230L

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)

1,234S

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)

1,259V

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)

1,260L

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)

1,264L

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)

1,285E

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)

1,289C

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)

1,292L

dimer interface
1,230L, 1,234S, 1,259V, 1,260L, 1,264L, 1,285E, 1,289C, 1,292L
CDD
cd00502 (DHQase_I)
shikimate binding ...

1,399D

shikimate binding site
1,399D, 1,535Y, 1,561L, 1,564Q
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,535Y

shikimate binding site
1,399D, 1,535Y, 1,561L, 1,564Q
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,561L

shikimate binding site
1,399D, 1,535Y, 1,561L, 1,564Q
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,564Q

shikimate binding site
1,399D, 1,535Y, 1,561L, 1,564Q
CDD
cd01065 (NAD_bind_Shikimate_DH)
NAD(P) binding sit...

1,431A

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,434T

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,454N

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,455R

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,494C

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,495V

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,496P

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,533V

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,557G

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,560M

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

1,561L

NAD(P) binding site
1,431A, 1,434T, 1,454N, 1,455R, 1,494C, 1,495V, 1,496P, 1,533V, 1,557G, 1,560M, 1,561L
CDD
cd01065 (NAD_bind_Shikimate_DH)

Protein sequence

>MCA_03457_1
MTDQVSKISILGSESIHIGYKFSNHIVSTVLSQLKSSTYVLISDDNIYRFGHVQRMEAQFLEALKQSSSSSRLLKFIVPP
GESSKTRATKAQIEDFLLKEKCTRDTVILAIGGGVIGDMIGYVAATFMRGVRFVQIPTTLLAMVDSSIGGKTAVDTPHGK
NLIGAFWQPKFIFMDLHFLETLPEREFYNGLAEVIKTAAMWDEEKFIQLEKDNEILMKYIKKRSSDGKVDLEPIIPIVRG
IVQGSASIKAEVVTLDEREGGLRNLLNFGHTIGHAYEAILTPYILHGECVSIGMVLEAEIARYLGHLSDGAVARLAKCLK
AYNLPITPNDPIVRSRSKNISTPVPKLLDIMNVDKKNDGNVKKIVMLTRIGKTLEKQATKVSDSIIQTILSEDFLITGNI
KSAPNTVEVTPPGSKSISNRALILASLGKGVCKIKNLLHSDDTQHMLTACQLLGGTTVSFEDHGEVLVVEGNGGHFLAPA
SEIYLGNAGTASRFLTTLATLVSPSGDANHVVLTGNARMKQRPIGPLVDSLNKNGCKIEYLESVGSLPLKIQSGTGFKGG
RIELEATVSSQYVSSILMAAPYASSPVTLALVGGKPISQLYIDMTISMMKTFGIEVEKSTTEANVYHIPQGTYTNPKEYV
IESDASSATYPLAFAALSGTTCTVPNIGSSSLQGDARFATDVLKPMGCTVTQTATSTTVTGPPVNTLKPIPSIDMEPMTD
AFLTASVLAAVANNNAESKTTNIYGIANQRVKECNRIDAMIHELAKFGVVTREHADGLEIDGIDISKLKVPKNGVHTYDD
HRVAMSLSLLASALEEEVLIKDRRCVEKTWPGWWDVLSRKFNISLRGFNNETEFSDSASSCGFKSPNEDKTIVLIGMRGA
GKTSLGQWVADSLGLKFVDMDQFLESNLGKSIPQVIEEQGWAGFRSEELKTLKEFLSTHPRGYVAACGGGIVETPEARDL
LKKYMSEDRIVIHIHRNVDDIVSYLNIDKTRPAFTNDIINVWEHRKGWYHECSNYIYYSLNFDIQLPNGSQAARHSLDMF
LRNITGSRDVSVHKQTDKRSAFVCLTLKDIRAFSGIKKCLVGSDAVELRVDLLKEQGQQGAIPRLEYVTEQVAYLRSVTD
LPIIFTVRTVSQGGQFPDNAEDEVEKLIRHAYRLGIEYVDLELTWSVPLVDALVKSRGHTRIIASHHNISGDLKWEGDGS
AVWEDYYERALSVGDVIKFVGMAHDLTDNLQLESFRAKHNSRKPLIAINMGDAGKLSRVLNTVLTPVTHESFPFMAAPGQ
LTVKEINQCLSLIGGLSKKEFFVCGSPVSKSKSPALHTACYKSLGLPHSYTTYESDDAEKVFEHIKSLGSKFGGASVTIP
LKLKVIPYLSELTPQAKLVGAVNTIIPLQDGKFRGDNTDWIGIVKSLESIGARKLQNSNLLEKHSALIIGAGGTSRAAIL
ACHELGFSTIYLINRTASKAQEVAKSFPTEYGVKFIDSTSDFSSLLSPLVVISCVPATIPLSDISEVVETVKKVITLKPE
NGHLPYQRCFLDVAYIPSVTPIMDFVEKVGSFRTIGGKDMLVYQGVEQFEIWTKCVAPVEEAKKAVYEQD

GO term prediction

Biological Process

GO:0009073 aromatic amino acid family biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0003855 3-dehydroquinate dehydratase activity
GO:0003856 3-dehydroquinate synthase activity
GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0004765 shikimate kinase activity
GO:0005524 ATP binding
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features