MIA_03199_1

Protein

Length

1,962 amino acids

Protein function

EGGNOG:	0PGN8	SWR1	Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling
SGD closest match:	S000002742	SWR1	Helicase SWR1
CGD closest match:	CAL0000190429	SWR1	Helicase SWR1

Protein alignments

	%id	Aln length
MCA_02918_1	67.928%	1163	MCA_02918_1
A0A0J9X4J6_GEOCN	67.171%	926	Similar to Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex OS=Geotrichum candidum GN=BN980_GECA03s00582g PE=4 SV=1
UniRef50_A0A0J9X4J6	67.171%	926	Similar to Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X4J6_GEOCN
A0A167ERA9_9ASCO	59.524%	966	Chromatin-remodeling protein SWR1 OS=Sugiyamaella lignohabitans GN=SWR1 PE=4 SV=1
A0A1E3PTU2_9ASCO	59.105%	983	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20676 PE=4 SV=1
A0A060SXZ3_BLAAD	66.924%	777	ARAD1A08426p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A08426g PE=4 SV=1
SWR1_YARLI	57.676%	964	Helicase SWR1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SWR1 PE=3 SV=1
SWR1_CANAL	54.180%	945	Helicase SWR1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SWR1 PE=3 SV=2
SWR1_YEAST	57.665%	848	Helicase SWR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWR1 PE=1 SV=1
A0A1E4THK7_9ASCO	60.230%	782	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_121715 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0563

Protein family membership

None predicted.

Domains and repeats

Domain
678 - 750
Helicase/SANT-associated domain (IPR014012)
1,015 - 1,297
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,299 - 1,367
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,431 - 1,447
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,641 - 1,819
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Domain
1,059 - 1,260
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
Domain
1,078 - 1,363
SNF2-related, N-terminal domain (IPR000330)
1,650 - 1,803
Helicase, C-terminal (IPR001650)

1 200 400 600 800 1000 1200 1400 1600 1800 1962

Detailed signature matches

IPR014012

Helicase/SANT-associated domain
1. SM00573 (bromneu2)
  
  679 - 750
  
  SMART
  SM00573 (bromneu2)
2. PS51204 (HSA)
  
  678 - 750
  
  PROSITE profiles
  PS51204 (HSA)
3. PF07529 (HSA)
  
  687 - 749
  
  Pfam
  PF07529 (HSA)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,299 - 1,367
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,641 - 1,819
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,431 - 1,447
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,015 - 1,297
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  1,075 - 1,240
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  1,059 - 1,260
  
  SMART
  SM00487 (ultradead3)
IPR000330

SNF2-related, N-terminal domain
1. PF00176 (SNF2_N)
  
  1,078 - 1,363
  
  Pfam
  PF00176 (SNF2_N)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  1,650 - 1,803
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  1,679 - 1,762
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  1,650 - 1,762
  
  Pfam
  PF00271 (Helicase_C)
IPR002464

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
1. PS00690 (DEAH_ATP_H...)
  
  1,186 - 1,195
  
  PROSITE patterns
  PS00690 (DEAH_ATP_HELICASE)

no IPR

Unintegrated signatures

Coil

1,920 - 1,940

COILS
Coil (Coil)

583 - 603

COILS
Coil (Coil)

723 - 751

COILS
Coil (Coil)
G3DSA:3.40.50...

1,033 - 1,296

GENE3D
G3DSA:3.40.50.10810 (G3DSA:3.40.50.10810)
G3DSA:3.40.50...

1,640 - 1,800

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd00046 (DEXDc)

1,083 - 1,222

CDD
cd00046 (DEXDc)
cd00079 (HELICc)

1,639 - 1,770

CDD
cd00079 (HELICc)
mobidb-lite (disord...)

505 - 534

MobiDB Lite
mobidb-lite (disorder_prediction)

342 - 465

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 274

MobiDB Lite
mobidb-lite (disorder_prediction)

619 - 647

MobiDB Lite
mobidb-lite (disorder_prediction)

1,863 - 1,947

MobiDB Lite
mobidb-lite (disorder_prediction)

882 - 1,049

MobiDB Lite
mobidb-lite (disorder_prediction)

804 - 869

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,091G

ATP binding site
1,091G, 1,092L, 1,093G, 1,094K, 1,095T
CDD
cd00046 (DEXDc)

1,092L

ATP binding site
1,091G, 1,092L, 1,093G, 1,094K, 1,095T
CDD
cd00046 (DEXDc)

1,093G

ATP binding site
1,091G, 1,092L, 1,093G, 1,094K, 1,095T
CDD
cd00046 (DEXDc)

1,094K

ATP binding site
1,091G, 1,092L, 1,093G, 1,094K, 1,095T
CDD
cd00046 (DEXDc)

1,095T

ATP binding site
1,091G, 1,092L, 1,093G, 1,094K, 1,095T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

1,191D

putative Mg++ binding site
1,191D, 1,192E, 1,193A, 1,194H
CDD
cd00046 (DEXDc)

1,192E

putative Mg++ binding site
1,191D, 1,192E, 1,193A, 1,194H
CDD
cd00046 (DEXDc)

1,193A

putative Mg++ binding site
1,191D, 1,192E, 1,193A, 1,194H
CDD
cd00046 (DEXDc)

1,194H

putative Mg++ binding site
1,191D, 1,192E, 1,193A, 1,194H
CDD
cd00046 (DEXDc)
nucleotide binding...

1,673Q

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,674M

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,675T

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,676R

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,696D

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,697G

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,724T

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,725R

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)

1,726S

nucleotide binding region
1,673Q, 1,674M, 1,675T, 1,676R, 1,696D, 1,697G, 1,724T, 1,725R, 1,726S
CDD
cd00079 (HELICc)
ATP-binding site c...

1,732N

ATP-binding site
1,732N, 1,753Q, 1,757R, 1,760R
CDD
cd00079 (HELICc)

1,753Q

ATP-binding site
1,732N, 1,753Q, 1,757R, 1,760R
CDD
cd00079 (HELICc)

1,757R

ATP-binding site
1,732N, 1,753Q, 1,757R, 1,760R
CDD
cd00079 (HELICc)

1,760R

ATP-binding site
1,732N, 1,753Q, 1,757R, 1,760R
CDD
cd00079 (HELICc)

Protein sequence

>MIA_03199_1
MPSYSSNHPQSQEKQKLSSSSLPSSFSKTPVDAADIKPTASPPAVSSSNNNNDSSISTHIQSPDIIAHETPFSASPTPDT
GLDDHPSNTAISATDNDSQDEKPASIQQNSLKNGSHRLPKRAFSTSTAPVTYSKRRRVSSTSSSTPPAPLRRSSRRSTAS
QVDYSPQGLERQRTKLKNPQPLPPQHPSSHTQTVRTRRSSIKQEEQPIVSANETHPTRAQARGRKNSRSESLNGSAKHVN
GTKQQPPHSRRVGSTAASSSHSPTPEPATASNEQLELASRIQQKKQYLSEVYDRHDFRVRLLFHLEKFVSLVSFDPEVAK
QDHSSVFEEYRQKYDLWAKVEANDTSSRRSRASRRRTHLQKDALNIISPAHSPASSAIVEIKKEDEVAPRHTTRRSASAR
SESPPRSTPSTRKRGAPATSKPKVEHKTRSSAAANSENSTPPPQQQPQSLINHPQVGSKNISGLMSDYGLEDDDVIDVIG
GNASSSEGYISDDFDEILFLNSSSESSLEDPHVSSESEIELNNESEIEPSSTQQYTPHLKIKFSLPDATITHPGHIAVPR
FDSLDKYLHSFVSLDEDISEQQREEYIQDQAKLRNRIEEVKASGMYDIYLEHLMEHAPGSNSAGGSGGSNLTGNNSSSGG
GNNAGTGGIGTATSTALSSAPLTIKSASSLISKLRRTFQDPIRLTQQPSHQDHLVSQAVYFSKLLSNERRSHISKSKKVA
AMVEQYFKRLSNAEEKERKQEETRIRKLARKTALEVMRKWKIAEKVVLHRRAKKLEDEERQAGKKQLNMILEHSAQLLEA
RVSTNADASKKAVDEDEDDLMSASDADAEAEEVLEGHDEEEEDTPMEDALEETPDDEVSRLRNIPDDQLTVEELRQKYAA
LPDIKLNWDHSEEKEENENSDVEPENPIFEDEERVKKAIQMDKDVEASDSDHSTVMDSEEDDDDEMEDSELSQSEDEEEN
AASLSDLFKGDANETKASEVEEKDTEETKAKVKEPKEEETEEKKTKDMDKITLENDEAKTKDNPDKSTSELIKSSRPATS
SPQLPPTTELVKTPIPFLLRGSLREYQHYGLDWLVGLYNNNTNGILADEMGLGKTIQTISLISYLACEKHVWGPHLIVVP
TSVMLNWEMEFKRFAPGFKVLTYYGNPMQRKQKRQGWNKEDTWHVCITSYQLVLQDQNAFKRKKWHYMILDEAHNIKNFR
SQRWQSLLNFNTEHRLLLTGTPLQNNLIELWSLLYFLMPSSRASQTMPEGFANLRNFQEWFSRPVEKMVEGGNYVDEEVK
ETVSKLHQILRPFLLRRLKADVEKQMPAKYEHVVYCKLSKRQRFLYDDFMSRAQTRETLASGNFLSIINCLMQLRKVCNH
PDLFEVRPIVTSMAVNRSVVADFEIKDLLIRKRLVDDISESSQKNINLDFLNLKFTQNDFNRTTGEAIATSRWGNSKRPL
IQEILSDQQQEVTKLQETTPRDLSSINGHLQYMNLVEKQDELINLESVIYQSHNKCERKPMYGADLIEKLSSVVSRPRPA
RGYDWNKSNIISSMMLNYEEQEAVMSDVIERYAFVTPKVVCLDMPRQVLGPKISELLSTMPANEPVVAMDEASHLNLVLD
GKNNDVSLPQSLWMTPDLKAIQSQTLFHQTLVKLSIAFPDKRLLQFDCGKLQRLAALLHDLIANGHRALIFTQMTRVLDI
LEQFLNLHGWRYLRLDGATRIEQRQILTERFNQDPKIPIFILSTRSGGLGINLTGADTVIFYDSDWNPSMDKQCQDRCHR
IGQTRDVHIYRLVSEYTIESNILRKAQQKQMLDNVVIQEGEFTTDYFTKLSVRDMLGDESLGGHSDEAVLSNSSRNLETI
LAAAEDDEDAKAAAAAMKEISNLDEEDFGESQRQQQQKDRASSVGTEVARGSTRISTPASDEGLAPSTRDTSTTPGHATE
EQAEDEGEDQEEEEEEEDDEIEGINSIDDYMIRFIENGYYWD

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005524 ATP binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_03199_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component