MCA_02918_1

Protein

Length

2,095 amino acids

Gene name: SWR1

Description: Helicase SWR1

Browser: contigB:2774517-2780940-

RNA-seq: read pairs 1955, FPKM 11.5, percentile rank 28.4% (100% = highest expression)

Protein function

Annotation:		SWR1	Helicase SWR1
KEGG:	K11681	SWR1	helicase SWR1 [EC:3.6.4.12]
EGGNOG:	0PGN8	SWR1	Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling
SGD closest match:	S000002742	SWR1	Helicase SWR1
CGD closest match:	CAL0000190429	SWR1	Helicase SWR1

Protein alignments

	%id	Aln length
MIA_03199_1	74.79%	952	MIA_03199_1
A0A167ERA9_9ASCO	58.50%	988	Chromatin-remodeling protein SWR1 OS=Sugiyamaella lignohabitans GN=SWR1 PE=4 SV=1
UniRef50_A0A167ERA9	58.50%	988	Chromatin-remodeling protein SWR1 n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A167ERA9_9ASCO
SWR1_YARLI	56.89%	951	Helicase SWR1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SWR1 PE=3 SV=1
A0A1E4THK7_9ASCO	57.73%	809	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_121715 PE=4 SV=1
A0A0J9X4J6_GEOCN	72.26%	530	Similar to Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex OS=Geotrichum candidum GN=BN980_GECA03s00582g PE=4 SV=1
A0A060SXZ3_BLAAD	64.65%	529	ARAD1A08426p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A08426g PE=4 SV=1
A0A1E3PTU2_9ASCO	59.52%	578	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20676 PE=4 SV=1
SWR1_CANAL	54.93%	537	Helicase SWR1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SWR1 PE=3 SV=2
SWR1_YEAST	55.84%	539	Helicase SWR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWR1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0062

Protein family membership

None predicted.

Domains and repeats

Domain
724 - 796
Helicase/SANT-associated domain (IPR014012)
1,160 - 1,361
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
1,779 - 1,932
Helicase, C-terminal (IPR001650)
Domain
1,149 - 1,398
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,400 - 1,468
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,770 - 1,948
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Domain
1,177 - 1,464
SNF2-related, N-terminal domain (IPR000330)

1 200 400 600 800 1000 1200 1400 1600 1800 2095

Detailed signature matches

IPR014012

Helicase/SANT-associated domain
1. PS51204 (HSA)
  
  724 - 796
  
  PROSITE profiles
  PS51204 (HSA)
2. PF07529 (HSA)
  
  738 - 795
  
  Pfam
  PF07529 (HSA)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,149 - 1,398
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,770 - 1,948
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,400 - 1,468
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  1,176 - 1,341
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  1,160 - 1,361
  
  SMART
  SM00487 (ultradead3)
IPR000330

SNF2-related, N-terminal domain
1. PF00176 (SNF2_N)
  
  1,177 - 1,464
  
  Pfam
  PF00176 (SNF2_N)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  1,779 - 1,932
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  1,808 - 1,891
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  1,779 - 1,891
  
  Pfam
  PF00271 (Helicase_C)
IPR002464

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
1. PS00690 (DEAH_ATP_H...)
  
  1,287 - 1,296
  
  PROSITE patterns
  PS00690 (DEAH_ATP_HELICASE)

no IPR

Unintegrated signatures

Coil

2,049 - 2,075

COILS
Coil (Coil)

264 - 288

COILS
Coil (Coil)

633 - 653

COILS
Coil (Coil)

1,707 - 1,727

COILS
Coil (Coil)

1,969 - 1,989

COILS
Coil (Coil)

777 - 797

COILS
Coil (Coil)
G3DSA:3.40.50...

1,165 - 1,399

GENE3D
G3DSA:3.40.50.10810 (G3DSA:3.40.50.10810)
G3DSA:3.40.50...

1,769 - 1,929

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd00046 (DEXDc)

1,184 - 1,323

CDD
cd00046 (DEXDc)
cd00079 (HELICc)

1,768 - 1,899

CDD
cd00079 (HELICc)
mobidb-lite (disord...)

666 - 703

MobiDB Lite
mobidb-lite (disorder_prediction)

855 - 965

MobiDB Lite
mobidb-lite (disorder_prediction)

977 - 1,143

MobiDB Lite
mobidb-lite (disorder_prediction)

550 - 587

MobiDB Lite
mobidb-lite (disorder_prediction)

1,995 - 2,082

MobiDB Lite
mobidb-lite (disorder_prediction)

378 - 520

MobiDB Lite
mobidb-lite (disorder_prediction)

329 - 359

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 256

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,192G

ATP binding site
1,192G, 1,193L, 1,194G, 1,195K, 1,196T
CDD
cd00046 (DEXDc)

1,193L

ATP binding site
1,192G, 1,193L, 1,194G, 1,195K, 1,196T
CDD
cd00046 (DEXDc)

1,194G

ATP binding site
1,192G, 1,193L, 1,194G, 1,195K, 1,196T
CDD
cd00046 (DEXDc)

1,195K

ATP binding site
1,192G, 1,193L, 1,194G, 1,195K, 1,196T
CDD
cd00046 (DEXDc)

1,196T

ATP binding site
1,192G, 1,193L, 1,194G, 1,195K, 1,196T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

1,292D

putative Mg++ binding site
1,292D, 1,293E, 1,294A, 1,295H
CDD
cd00046 (DEXDc)

1,293E

putative Mg++ binding site
1,292D, 1,293E, 1,294A, 1,295H
CDD
cd00046 (DEXDc)

1,294A

putative Mg++ binding site
1,292D, 1,293E, 1,294A, 1,295H
CDD
cd00046 (DEXDc)

1,295H

putative Mg++ binding site
1,292D, 1,293E, 1,294A, 1,295H
CDD
cd00046 (DEXDc)
nucleotide binding...

1,802Q

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,803M

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,804T

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,805R

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,825D

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,826G

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,853T

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,854R

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)

1,855S

nucleotide binding region
1,802Q, 1,803M, 1,804T, 1,805R, 1,825D, 1,826G, 1,853T, 1,854R, 1,855S
CDD
cd00079 (HELICc)
ATP-binding site c...

1,861N

ATP-binding site
1,861N, 1,882Q, 1,886R, 1,889R
CDD
cd00079 (HELICc)

1,882Q

ATP-binding site
1,861N, 1,882Q, 1,886R, 1,889R
CDD
cd00079 (HELICc)

1,886R

ATP-binding site
1,861N, 1,882Q, 1,886R, 1,889R
CDD
cd00079 (HELICc)

1,889R

ATP-binding site
1,861N, 1,882Q, 1,886R, 1,889R
CDD
cd00079 (HELICc)

Protein sequence

>MCA_02918_1
MPSQNNTNNSHSKNNDISNKSSETPTDIKTPIVQSSKENSKTQSTTTDKMLDTTQEQDIDVQSSKQENNRQEAIEVNGSD
DELSSLSDIDQQSVTSQQDEDETKQETDINENPNKRQSSVSEDDSKKISLRSSTRHKRDLSISKSSESASKRRKLNDLAA
TPLRRSSRKSTTNINYSPHSVDSKSKKTNSRETPTSKSTSRSSNVITVDDETPHSATRSRRQSNLHHNESTTTPSRKPTR
SVSMSPQPQTASSNTEAVAIDPEQQELLDQIQEKKQELAEIYNRHDDRVRLLFHLEKFVSLISFDPQVAKADHSNVFEEY
QTKYDLWSKIDTDGPSTRSSRPGRSRSTRRQAHIHQQDIFNILNNLNGTSKAPITISRNASEEPSNTPAPVVQSKTPQTN
GKAKSTPSKTTHTSASSTTSTPARSSRRSRTSIKVEEPAPATNSKSTRKSTAADETALPSKRSQRSVVSSKNITYSTYKR
LKSRSKRSRSRASSTESEALSGNEADHEHENTDEGSDDDVKLIDTLRDISSSEGFESDDFDAVLYLNSDDEKHRSKQSES
SDNDLSSMEEDDEEVKTEPSERSHTPRIRVKFSVPPPTVTHPRHLAVPQFGGSLDKFLSSFVSLDEDITEEQQDQIVQQQ
AHLRNRIEELKANGMYDLYVQRLSLNGNDKDKDKHHNEAREQTPKKEESNADKDAEQSSDSDDNVHFITASSSAQLPSLL
RKGFQDPFLLQQQPLYIDHFVAQAKFFSKLLSEERRKHISRSKKLSSMVEMFFKRRLNAEERERKMEEKRVRQLARKTIL
EVMKKWKIAEKVVQHRRAKLLEDEERQAGKQQLNMILEHSAQLLEARVVALNKGASADKDESEQPNGQENDDDELFSDVN
DSDDRMDLDSSSRQETPQVEPANDGEEPSDIEEKPDDEEGKQSVIDGSPALDKDSLSQQLSDEEDDSKTDETSNKYRNIP
DDQLTVEQLREKYSALPDVKLDFDHSEDEDKEEEDDVIFEDEEKVKKAMAMDNDVDFSESDHSTVMDSEESSDEDMDDES
EGNDVGLAALLDASDNNKEEEKAEPSSSLEPAKEKESKSEPEKEESPTESKTKSTPEPEELKSKSTTPAPGSIANKPERN
SSSPAPNNETALTTTEKSAPTQGFSSAAVDVVKTPIPFLLRGSLREYQHYGLDWLASLYNSNTNGILADEMGLGKTIQTI
ALISYLACEKHVWGPHLIVVPTSVMLNWEMEFKRFAPGFKVLTYYGNPIQRKEKRRGWNKEDTWHVCITSYQLVLQDQNA
FKRKKWHYMILDEAHNVKNFRSQRWQSLLNFNTKHRLLLTGTPLQNNLVELWSLLYFLMPSQRSSDSMPEGFANLRNFQE
WFSKPVEKMVEGGDYVDAEVKETISKLHIILRPYLLRRLKADVEKQMPAKYEHVVYCKLSKRQRFLYDDFMSRAQTRETL
ASGNFLSIINCLMQLRKVCNHPDLFEVRPIVTSLALNKSVVSDFEPKDFLLRKRLVGEIDESFENSLNLDFMNFRFTQNE
SKIGKNESISTQKWGGSKTPLIQEILEHQTQEVVKGRATTKRDLSSINGHLQYMSLLEKEDDLVKLESTIYQSQFKCNRS
PVYGKELIQKLSSIAQAPSTNTGRNYDWASSDVLDSMKLSYEEREEAVSEVIDRYAFVTPKVVCLDIPRIVLGPSISELL
SVTPVPDKPLNERENEIFIGSTGNDGIVDLTNDKEASKDNANQSEELGRPLSLKDINDESKKIMEDLRYIKSQSLFHKSL
VKLSIAFPDKRLLQFDCGKLQRLANLLHDLISNGHRALIFTQMTRVLDILEQFLNLHGYRYLRLDGATRIEQRQILTERF
NHDPKIPIFILSTRSGGLGINLTGADTVIFYDSDWNPSMDKQCQDRCHRIGQTRDVHIYRLVSEYTIESNILRKAQQKQM
LDNVVIQEGEFTTDYFTKLSVRDMLGDDSLGGYANETVLDTNGGKGKNLERLLAEAEDADDAKAAAAAMKEVSNLDAEDF
GDQQSSTKKRRASSAPGVAVNGKTRHETPLDEQRPSSTENRSVTPMTEYSNQDNAQEEFEEEDEEEEEEDDEEDDGINSV
DDYMIRFIENGYYWD

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005524 ATP binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_02918_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component