Protein

MIA_03180_1

Length
1,912 amino acids

Browser: contig04:468398-474417+

Protein function

EGGNOG:0PHWPHistone-lysine N-methyltransferase
SGD closest match:S000003704SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific
CGD closest match:CAL0000174178SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific

Protein alignments

%idAln lengthE-value
MCA_03934_164.387%4242.78e-177MCA_03934_1
A0A0J9XK07_GEOCN56.267%3592.87e-128Similar to Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation OS=Geotrichum candidum GN=BN980_GECA20s01858g PE=4 SV=1
UniRef50_A0A0J9XK0756.267%3595.87e-125Similar to Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XK07_GEOCN
A0A060TD66_BLAAD54.237%2955.02e-107ARAD1D04708p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04708g PE=4 SV=1
W0TYN1_YARLI41.975%4053.53e-89YALI0D21684p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D21684g PE=4 SV=1
A0A1E3PHP4_9ASCO51.351%2223.00e-72SET domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46750 PE=4 SV=1
A0A1E4TFS7_9ASCO34.653%3038.32e-52Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2256 PE=4 SV=1
SET2_YEAST35.193%2338.24e-39Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SET2 PE=1 SV=2
A0A167EAW9_9ASCO39.153%1892.83e-38Histone-lysine N-methyltransferase OS=Sugiyamaella lignohabitans GN=SET2 PE=3 SV=1
SET2_CANAL39.683%1896.92e-35Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SET2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9399
Predicted cleavage: 28

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1800 1912

Detailed signature matches

  1. Domain IPR006560
    AWS domain
    1. PS51215 (AWS)
  2. Domain IPR001214
    SET domain
    1. PF00856 (SET)
    2. PS50280 (SET)
    3. SM00317 (set_7)
  3. Domain IPR003616
    Post-SET domain
    1. PS50868 (POST_SET)
    2. SM00508 (PostSET_3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.170.2...
  2. SSF82199 (SET domain)
  3. mobidb-lite (disord...)

Protein sequence

>MIA_03180_1
MPPKGGKQSSLSKVPASRRVLRAHSRLSAAHDIHMFFAESPIPTFRHQVLEAYVRAIAQEYESEIEPGHENDSDLERKRS
AARPRKKTHVSTNSASDSASDSLIPLSKHLSNEDMDGSPVTLQHLTRKVYLRSGLFCEVQHRKKNTQKPFVFSLPVKTST
LLTDQQDFALPFAIYNSLPAGNPHWKNLKKNVWVDVDVPSFHGPRALCSCTKTCDEDCLNRMLQYECDEETCPFGKNDCG
NRAFQVLTKELQRGKRYSNGFEVAWLGLRGYGLKTTRPYAPGELIIEYCGDVISPTEMKRRMKEHYLDSKNHYFLSLENG
CVIDSGLKGSAARFANHSCSPNSEMQKWYVNGIPRIGLFASESIPPNTELTYDYNFDWFEGAKMQVCLCGEPNCRGYIGK
RTSRRPTPDDQPDETIKKRTNRRKNTTTDSAWKTPVLRAEESTEKEPTKISRPSSKTSSLTESKKSSKETTPKSDVDDSD
SSFADADGEDENPEEEEFETIAPKRTRSRAKYHRRIIEDSPVAPVERVTRSKRKLIDLTDANDATKSDTSPPPPPPPKRT
RASGSKSSPLTSIDDKKENISAAAKPEEPKVVSGAALSKHITLTYTSIDSRKTKSQAAESSATSNQPKDSATGTKTIRRV
SVADLTNNSPESPDQEAKPLQESKALLQGPEASQPVSNVDKPAPQTTFSASSSPLELPQEPKDSVVVESNQLLVTYSEPL
NSNRKLSSGSSRSSLADLMNPVEEEDKSRSMERSESSSASSFDFSKSSVSLATTYSSSSVTSGSNRRSSVSSILNHTSTV
DQSHSLSRTPSYDHQRLSQNLSNQMTTVVTHVPANSSPRSSWSSSGSPAFADPNVQDVPKNLPQLQSSPHYQGGGDPRNR
MPDSWRYDQNMENTYSHQQRPADISKKQSDFQLPVPQLISDMQRTKSTNPILYHGQQALRPPPPPSTFSSSASYIPQQQQ
KQHDSSTHGLPISGAKPLDRSYSYQPHHPPFNSPQKSIDGYNRIGSPELKSPIQHSNPLPTPPGLTPSNRAPYLPPSGLV
NPGPYNRIQQYPEINGVNNHPQVSTSPNHTSQAHLMRQTQLPQLPQIIHPPPPPLPRNPSDPHPMDKPMPPGHGSSAYLS
NHMAYRPMGPDSNPKESQMEFVPPNPQVNVRQIPEPILPSEILNSSKERLSISSLTSSNQSEDLAAIPVSKPDNGHSQPA
SINQSHLLNTENPESTQNKVNRTPRRGRPSLNKPIQPASGFAGIKPKRGRPKTNPTVVAAAAAAASASKTSAKVVAASAA
KQRNSDFRMVVSGPQNFQPSSAVDLASRNVINQVSAEQKSSQQPATTVSYESSIHEKPTFKPRESSISQLLIQPGTSAEK
TFVHSVSSPTIVPSEENERGFDQSRLGSQQRQPPLQHAKSVDSQQHFQPPRLNPYGPQHKQPQQQHYNPPFTHVSVPPVA
VPAPQVQLPTPQYLNPPPPPPPSYLEVPPTNSKNILSIQSLTNPDTNEEKLLTRLPSPGVSEKENLVTSHSFSQTTDRTK
AKTKAKGKGKSVRKSITPENLSPTSLAKATTSSEDDEALENSNSGSNSSSSNNSRRSSGDVKNNESSTSCSSSQSNESTT
SGESAPKKRGRPKLSTGGGKARRGRPPNSGPVQRLTLAPLALRTPVPLQAAPALLARIGTKTSPKPIESAALLSNKRPIA
PAPPSDPLKTRSLGTKAKSLESSSQTAGPSGLSSSSNGDSPGMKRPGSIVASTPSKKSTGKSKTRPILPSASVVQPIAPM
PASMTNPQAPVSVASGSARALSNLVSTSASFSSNNPLPAPRRRGRPRTKPFVPPPRGQLTTIAPNPQTPMNPNSRPQPNL
LWNRQLRKSDDSIPRTSNVGLNNISSNLLPTAAAAAAAAASTTPPGSTGSGTSENSGLRAQSTSQVNEQPPK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

GO:0005634 nucleus