Protein

MCA_03934_1

Length
2,049 amino acids

Browser: contigC:1532600-1539126-

RNA-seq: read pairs 1728, FPKM 10.4, percentile rank 26.6% (100% = highest expression)

Protein function

EGGNOG:0PHWPHistone-lysine N-methyltransferase
SGD closest match:S000003704SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific
CGD closest match:CAL0000174178SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific

Protein alignments

%idAln lengthE-value
MIA_03180_163.49%4413e-177MIA_03180_1
A0A0J9XK07_GEOCN54.86%3707e-125Similar to Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation OS=Geotrichum candidum GN=BN980_GECA20s01858g PE=4 SV=1
UniRef50_A0A0J9XK0754.86%3701e-121Similar to Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XK07_GEOCN
A0A060TD66_BLAAD55.93%2952e-106ARAD1D04708p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04708g PE=4 SV=1
W0TYN1_YARLI50.17%2996e-91YALI0D21684p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D21684g PE=4 SV=1
A0A1E3PHP4_9ASCO48.90%2272e-70SET domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46750 PE=4 SV=1
A0A1E4TFS7_9ASCO36.86%2939e-57Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2256 PE=4 SV=1
A0A167EAW9_9ASCO40.21%1897e-39Histone-lysine N-methyltransferase OS=Sugiyamaella lignohabitans GN=SET2 PE=3 SV=1
SET2_YEAST39.38%1933e-38Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SET2 PE=1 SV=2
SET2_CANAL36.79%2121e-35Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SET2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7616
Predicted cleavage: 28

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1800 2049

Detailed signature matches

  1. Domain IPR006560
    AWS domain
    1. SM00570 (shorttest3)
    2. PS51215 (AWS)
  2. Domain IPR001214
    SET domain
    1. PF00856 (SET)
    2. PS50280 (SET)
    3. SM00317 (set_7)
  3. Domain IPR003616
    Post-SET domain
    1. PS50868 (POST_SET)
    2. SM00508 (PostSET_3)
  4. SITE IPR017956
    AT hook, DNA-binding motif
    1. SM00384 (AT_hook_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:2.170.2...
  3. SSF82199 (SET domain)
  4. mobidb-lite (disord...)

Protein sequence

>MCA_03934_1
MPAKGTSKASVPAPQEPRRFLRVHSRLSACNELRNFFSTSPIPSFRHQYLEAYVRAIAQEYESEPERPPATKPTTPAESA
KPASSGTNKKKPLAAQSSTSSSSGSQQKSKATSTFTSKLEDYDDIDPSSIEETVYPTRKIYLTSGFYCDLRRKKNASKRF
TFPLPQPKKSTILTERQDFKLPYVVYNELPPAPLNWKNLKKNMWIDVEPPYSRAPRPKCTCTKSCDEDCLNRILQYECDE
HICPLGKEDCGNRAFQVLTKELQRGKRYANGFEVVWLGLRGYGLKSTRSYMPGELIIEYCGDVISPTEMQRRVTEHYSES
KNHYFLSLENGCVIDSGLRGSAARFANHSCRPNAEMQKWYVNGLPRIGLFASESIPAGTELTYDYNFDWFEGAKMQVCLC
GEPNCRGYIGKRTSRRPTPEEALQGDSQKKRPGRRKQSATKGRSTTVSSTSKEPPSTPSLSTTSTHIRTSRRPNSATENN
KSTSQNAKSDHTNNEEPQDTDSNYENDEQTTSNAVIKRPRGRPRSSAKSATEDSSSQIPSTPSPSPSPSPSIASETATSE
TAERVTRSKRKLLANNSDDVPITQRTRRRQSVASSKRSLSRTRNSFKRRKIISDDEKAEEDISEFEHSDDQTSKVKRINV
SEDEEMPETTKVKQALSKGKKIHTKMEITTSKSSKGDIESKIEAYNNEKESKIATKALNDVVDTFISSSTRNKSFKNNAS
SPLSPSFPTISAIDDTDNSDSEVMARQSSNFKSVNSISTVLSSPSKSQSSSGSLRRVSVASLTEPSPSLSTKNSKSHSNI
TLLLDSTNDSTDKDDSNKRRASISPGKSSSSFLSNLMNPVNAAQKPAETQNQHCPPSPLSRKPSVSSILNIEPSSTHRES
RSTISPSQHTSEVPTQYQQAAYPQQNAPTTTPVSNNQESGRKKSIVLDVSTDPEKYRLPHPVSGDTSWRREFMPPKDPHS
QDQQVQPVQNASELQKPSNTRQGPIQLAIPPLLLGLQNPNKNSLSSNQTSSVVSPVQAHPPPVQQQPVASSQPLISNAYN
PGPPQTIPPQVNSSYNPHLNPPGYAQYRHPNQHDAQIPQEEYDANKPIYSQPPTSPSQQIHMQLPLQQEKRFTHHHEPNT
PAMPPNHMQPHSSLPPIASTGLSQQALEPRYVMNPQAELHSPIEQRPHRIPGGNNQMGANYNYAYDMNRPSSNSVSPTLY
QNSPPSINQSPPERRFNNAPLPHSAYQAPSSIQQHISQQQPHSPYNLQKQSVQAPKSVPFTSPQAQYRLPPPPPPQQLSS
QLHPNNPLQIQDRSHPQEQQVVYPSQRPSHLEQGYVENSINWVRSNPSPASSESSANKRFNNRTVDSSVVLENVNTTKAR
LSISTLMSTDPQSSDLSQNMASSGTADMRREPTNVTDNASSSKSLASDKNKRGKHTLMTTPNQQGVKPRRGRPKLLNHNR
APKPLLKIAPDPNTQLPTGEGRASFRFTGANAPKTGFSDGSAPAPSSSMTPRVPILPVASQQGNNSQKVVAKQSIPINLK
KNNTPVQSSKSNSTEALSRTQFVAPASAQLESTTQQRGETTTKPTVSSTNPLSIKSITSRDITSSKSSSEPSSKSSSLPN
NNGEKKPLSASVQPNTENLPGETSKRRGRPKLSPVTGSKPRRGRPPNSGPAQRLTLAPLASRPPSSPPATPEMLARIGIK
STITRLPDSHPIVVTTPQTYKKTTPLISSPSALLSNSIRKTLSLATSGSPPQAIQATAPGSSKPLSKTPSLHKSNTGNTN
ESNNNTPVRPTSTTATSSYPVLKKPVSQSPSGLQPSLKRPSDATSSSKTPSTKKYKYSSENSPSNSKSGTEEANSTSKSH
SGSSSSSSSSVSPNVSEPPKKRGRPRTRQIGVMIGGTRNPNLTLVPSPMPPLQPLMAGNRGPIIGEGNGSVVLKHIRRMN
HDASLVPRSFASKLDNESSSSKGDGKRVISAGDSRKSINISQKSTTTISGGNNSNKSGGIKFINSSSSSSTTSSSPNTKS
NDASSSMGILNKSNEDGDNTGKSKPVVETSITNANNKNNSNNPIEAEVM

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003677 DNA binding
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

GO:0005634 nucleus