MIA_03171_1
Browser: contig04:441015-443453+
Protein function
| EGGNOG: | 0PFAD | FG02506.1 | bifunctional purine biosynthetic protein |
|---|---|---|---|
| SGD closest match: | S000003203 | ADE5,7 | Bifunctional purine biosynthetic protein ADE5,7 |
| CGD closest match: | CAL0000199243 | ADE5,7 | Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_03937_1 | 86.73% | 784 | 0.0 | MCA_03937_1 |
| A0A0J9XK13_GEOCN | 81.53% | 785 | 0.0 | Similar to Saccharomyces cerevisiae YGL234W ADE5,7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway OS=Geotrichum candidum GN=BN980_GECA24s01187g PE=3 SV=1 |
| A0A167CT56_9ASCO | 72.97% | 788 | 0.0 | Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase OS=Sugiyamaella lignohabitans GN=ADE5,7 PE=3 SV=1 |
| A0A1E3PQN2_9ASCO | 70.90% | 787 | 0.0 | Phosphoribosylformylglycinamidine cyclo-ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80913 PE=3 SV=1 |
| A0A060T238_BLAAD | 71.05% | 784 | 0.0 | ARAD1C25982p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25982g PE=3 SV=1 |
| PUR2_YARLI | 68.48% | 790 | 0.0 | Bifunctional purine biosynthetic protein ADE1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ADE1 PE=3 SV=1 |
| UniRef50_A0A1C7NQ99 | 62.37% | 792 | 0.0 | Bifunctional purine biosynthetic protein ADE1 n=7 Tax=Opisthokonta TaxID=33154 RepID=A0A1C7NQ99_9FUNG |
| A0A1D8PE67_CANAL | 62.08% | 799 | 0.0 | Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE5,7 PE=3 SV=1 |
| A0A1E4TLY0_9ASCO | 61.75% | 787 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_92625 PE=3 SV=1 |
| PUR2_YEAST | 57.50% | 800 | 0.0 | Bifunctional purine biosynthetic protein ADE5,7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE5,7 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1594
Predicted cleavage: 18
Protein family membership
- Phosphoribosylglycinamide synthetase (IPR000115)
- Phosphoribosylformylglycinamidine cyclo-ligase (IPR004733)
Domains and repeats
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Domain
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Domain
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Domain
Detailed signature matches
no IPR
Residue annotation
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dimerization inter...
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putative ATP bindi...
Protein sequence
>MIA_03171_1 MSDSSLTILLVGNGGREHALAWRLAQSPSVKTIYVAPGNGGTANGLNKVQNIDISSGDFPKLVEFAQKNDVNLVVPGPEQ PLVDGIETYFRKVGIPTFGPSAKAAVMEGSKTFSKDFMAKHNIPTAEFQNFTDYEKAKAYIASVNHNVVIKASGLAAGKG VLIPQNKEEAYAALKEVMEDRAFGDAGDEVVIEEFLEGDELSILAFSDGYTIVDLPPAQDHKRIGEGDTGLNTGGMGAYA PAPIATPKILDEIRETILKPTIAGMRKDGFPFVGILFTGIMLTKNGPKTLEYNVRFGDPETQTVLPLLSKDTDLAQIFLA CAEGRLDSVDIKISPGYAATVVMSAAGYPESYKKGDVITVGDISENNYIFHAGTAIKDGKVVTAGGRVIASSATAPTLEG ALKLAYEGVDKVNFEGKYFRRDIAHRGLRDLKLLGSAQYGITYAQAGVDVDEGNRFVEQIKASVRSTKRPGADAEIGGFG GIFDLKAAGYEDALLVGATDGVGTKLIIAQSTGIHNTVGIDLVAMSVNDLIVQGAEPLFFLDYFACGKLDSKTAADFVSG VSEGCVQSACALIGGETAEMPGLYSEGDYDCNGTCVGAVERTKVLPNLDAFAPGDVVLGLASSGVHSNGFSLIRKILEVS NLSYSDKAPWTSENKTVGESLLTPTRIYVKSLLPVIKKDLILGLANITGGGLIENVPRVLPKHLNATIDVTSYQVPELFK WFANAGKVPVADLGKTLNMGIGMIVIVKPENVAAVTEELTKGGETVFEIGKLEAGEQKCILTNIDNWIN
GO term prediction
Biological Process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009113 purine nucleobase biosynthetic process
Molecular Function
GO:0003824 catalytic activity
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm