MCA_03937_1
Browser: contigC:1562119-1564555+
RNA-seq: read pairs 5643, FPKM 88.7, percentile rank 76.9% (100% = highest expression)
Protein function
| KEGG: | K11788 | ADE5 | phosphoribosylamine--glycine ligase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 6.3.3.1] |
|---|---|---|---|
| EGGNOG: | 0PFAD | FG02506.1 | bifunctional purine biosynthetic protein |
| SGD closest match: | S000003203 | ADE5,7 | Bifunctional purine biosynthetic protein ADE5,7 |
| CGD closest match: | CAL0000199243 | ADE5,7 | Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03171_1 | 86.73% | 784 | 0.0 | MIA_03171_1 |
| A0A0J9XK13_GEOCN | 80.25% | 785 | 0.0 | Similar to Saccharomyces cerevisiae YGL234W ADE5,7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway OS=Geotrichum candidum GN=BN980_GECA24s01187g PE=3 SV=1 |
| A0A167CT56_9ASCO | 73.25% | 785 | 0.0 | Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase OS=Sugiyamaella lignohabitans GN=ADE5,7 PE=3 SV=1 |
| A0A1E3PQN2_9ASCO | 71.78% | 783 | 0.0 | Phosphoribosylformylglycinamidine cyclo-ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80913 PE=3 SV=1 |
| A0A060T238_BLAAD | 72.12% | 782 | 0.0 | ARAD1C25982p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25982g PE=3 SV=1 |
| PUR2_YARLI | 69.85% | 786 | 0.0 | Bifunctional purine biosynthetic protein ADE1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ADE1 PE=3 SV=1 |
| UniRef50_A0A1X2HH09 | 63.46% | 791 | 0.0 | Phosphoribosylglycinamide synthetase n=2 Tax=Syncephalastrum racemosum TaxID=13706 RepID=A0A1X2HH09_SYNRA |
| A0A1D8PE67_CANAL | 62.99% | 797 | 0.0 | Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE5,7 PE=3 SV=1 |
| A0A1E4TLY0_9ASCO | 61.73% | 784 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_92625 PE=3 SV=1 |
| PUR2_YEAST | 57.97% | 797 | 0.0 | Bifunctional purine biosynthetic protein ADE5,7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE5,7 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.2415
Protein family membership
- Phosphoribosylglycinamide synthetase (IPR000115)
- Phosphoribosylformylglycinamidine cyclo-ligase (IPR004733)
Domains and repeats
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Domain
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Domain
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Domain
Detailed signature matches
no IPR
Residue annotation
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dimerization inter...
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putative ATP bindi...
Protein sequence
>MCA_03937_1 MSEPLTILLVGNGGREHALAWRLSQSPSVKTIYVAPGNGGTASGLEKVQNIDIGSGDFDKLVEFALKNNVNLVVPGPEQP LVDGISTYFKKVGIPTFGPSAKAAVMEGSKTFSKDFMAKHNIPTAEFQNFTDYEKAKQYIAQVNHNVVIKASGLAAGKGV LIPQTKEEAYAALKEVMEDKAFGDAGDEVVIEEFLEGDELSILAFSDGYTLVDLPPAQDHKRIGENDTGLNTGGMGAYAP APIATPQLLKDIRENILQPTIDGMRKDGFPFVGILFTGIMLTSNGPKVLEYNVRFGDPETQTVLPLLSKDTDLAQVMLAC AEGRLDSVNIKVAPGFGATVVMSAAGYPESYKKGDKITIGEISENNYIFHAGTAVKDGAIVTAGGRVIASSAVAPTLEEA LKLAYEGVDKVNFEGKYFRRDIAHRGLRDLKAMKNQGITYAQAGVDVDEGNRFVEKIKASVRATARPGADAEIGGFGGLF DLKAAGYEDALLVGATDGVGTKLIIAQSTNIHDTVGIDLVAMSVNDLIVQGAEPLFFLDYYASGHLDSKNAADFVAGVSE GCIQSGCALIGGETAEMPGLYKAGDYDCNGTCVGAVERNKILPRIDEFAEGDIVLGIASSGFHSNGFSLVRKIVEHAGLT YSDKAPWDESTTVGKSLLTPTRIYVKSLLPVIKKGLILGLANITGGGLVENVPRVLPKHLNANVDVTSYKLPELFKWFGK AGKVPFNDLGKTLNMGIGMVVIVKPENAATVTEELVKGGETVYTIGKLEKGEQKCVLTNLEKWLD
GO term prediction
Biological Process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009113 purine nucleobase biosynthetic process
Molecular Function
GO:0003824 catalytic activity
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm