Protein

MIA_03145_1

Length
1,015 amino acids

Browser: contig04:333425-336473+

Protein function

EGGNOG:0PH8VHMG1)-reductase
SGD closest match:S000004540HMG13-hydroxy-3-methylglutaryl-coenzyme A reductase 1
CGD closest match:CAL0000177752HMG13-hydroxy-3-methylglutaryl coenzyme A reductase

Protein alignments

%idAln lengthE-value
MCA_01061_171.374%10480.0MCA_01061_1
A0A0J9XDC5_GEOCN66.112%10210.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Geotrichum candidum GN=BN980_GECA11s02551g PE=3 SV=1
A0A060TIU1_BLAAD58.942%10400.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D41008g PE=3 SV=1
A0A167E1N8_9ASCO57.555%10390.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Sugiyamaella lignohabitans GN=HMG1 PE=3 SV=1
A0A1E3PIB7_9ASCO55.005%10290.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83223 PE=3 SV=1
Q6C704_YARLI53.333%10200.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E04807g PE=3 SV=1
UniRef50_Q6C70453.333%10200.03-hydroxy-3-methylglutaryl coenzyme A reductase n=7 Tax=Saccharomycetales TaxID=4892 RepID=Q6C704_YARLI
HMDH1_YEAST46.054%10770.03-hydroxy-3-methylglutaryl-coenzyme A reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HMG1 PE=1 SV=1
A0A1D8PD39_CANAL72.176%4780.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HMG1 PE=3 SV=1
A0A1E4TCF7_9ASCO70.938%4370.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32696 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9463

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 1015

Detailed signature matches

  1. Family IPR002202
    Hydroxymethylglutaryl-CoA reductase, class I/II
    1. PF00368 (HMG-CoA_red)
    2. PS50065 (HMG_COA_RE...)
    3. PR00071 (HMGCOARDTASE)
  2. Family IPR004554
    Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
    1. TIGR00533
    2. cd00643 (HMG-CoA_re...)
  3. Domain IPR025583
    HMG-CoA reductase, N-terminal domain
    1. PF13323 (HPIH)
  4. Domain IPR000731
    Sterol-sensing domain
    1. PS50156 (SSD)
    2. PF12349 (Sterol-sen...)
  5. Domain IPR009029
    Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
    1. SSF56542 (Substrate...)
  6. Domain IPR023282
    Hydroxymethylglutaryl-CoA reductase, N-terminal
    1. G3DSA:1.10.32...
  7. Domain IPR009023
    Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
    1. G3DSA:3.30.70...
    2. SSF55035 (NAD-bindi...)
  8. Domain IPR023074
    Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
    1. G3DSA:3.90.77...
  9. SITE IPR023076
    Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
    1. PS00066 (HMG_COA_RE...)
    2. PS01192 (HMG_COA_RE...)
    3. PS00318 (HMG_COA_RE...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:1.20.16...
  3. NON_CYTOPLASM... (N...)
  4. SIGNAL_PEPTIDE (Sig...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)

Residue annotation

  1. tetramerization in...
  2. inhibitor binding ...
  3. catalytic residues...
  4. substrate binding ...
  5. NADP(H) binding si...

Protein sequence

>MIA_03145_1
MSTASSLFKPFMSLVVYISVHAAKRPIHTIVSIAALATTAYFSILDLSVGPANLDSFAVSYYHPGGPASNASEWVPVSSS
SEYPDAPHFASAKLVFAGLPSAQVPPVVPNTFDSDVNPHEKSLVVPYDELSQWLKDSAVLSGPDQEPWRLRQSFSWILWA
KWNFTRLLDLIHATETFDLAVIFIGYLAMYFTFISLYISMKHLGSKFWLATSVMLSSTFAFMFAFVTSFSLGVPVSLITL
SEGLPFLVATVGFGNKIKLTRATLKAVRSRPPGSSIEHVVSDVLSTQGTLMLRDYALEIIALLGGAYFGVNGLWQFCFLS
AWILFYDYILTATFYSAILSIKVEIGKIKQKESIRQALEEDGVSESVAESVAEASTDTPGTKSNLSITFFKIFMVSAFLF
LNFVQLSPSVFQAFSKKSSSSETLFNLVPFGDTGVVVTILPTLIFEHASLSARFDTVFHRVLNRLTETLADPLISKFILI
GLAISIGLNAYLFRAAQDPVVVKVVEKVVEVEKKVHVYLRKTDTPPSDRSSVGSSSSNDAGLELQIGKTIIEEDYEEVKL
RSLQESESYLKAGNAKLLNDEELVNLALAGKLPLYAYEKTLADNARAVNIRRAVVSRLSDTKKLESSKLPYLHFDYDRVF
GACCENVIGYIPLPVGVAGPLVIDGKEYFIPMATTEGCLVASTMRGCKAINAGGGVTTVLTHDGMTRGPCVQFPSLRRAG
EAKLWLDSEEGQRTIKKAFNSTSRFARLQTIKTAMAGTLLFVRFCTTTGDAMGMNMISKGVEYSLKYMAEQCGFEDMEEI
SVSGNYCSDKKPAAINWIEGRGKSIVAESLIPKAVVEKVLKSDVDALVELNISKNLVGSAMAGSIGGNNAQAANLVAAIY
LATGQDPAQVVESANCMTLMKNVNGDLHLTVSMPSIEVGTIGGGTILEAQGAMLDLLGVRGPHPTDPGSNARQLAKIVAS
GVMAAELSLCSALAAGHLVQSHMALNRSKAPTPNPGASSADIKRLTEGSQICIKS

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0050662 coenzyme binding

Cellular Component

GO:0016021 integral component of membrane