Protein

MCA_01061_1

Length
1,089 amino acids

Gene name: HMG1

Description: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Browser: contigA:3376731-3380001+

RNA-seq: read pairs 3770, FPKM 42.7, percentile rank 61.9% (100% = highest expression)

Protein function

Annotation:HMG13-hydroxy-3-methylglutaryl-coenzyme A reductase 1
KEGG:K00021HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
EGGNOG:0PH8VHMG1)-reductase
SGD closest match:S000004540HMG13-hydroxy-3-methylglutaryl-coenzyme A reductase 1
CGD closest match:CAL0000177752HMG13-hydroxy-3-methylglutaryl coenzyme A reductase

Protein alignments

%idAln lengthE-value
MIA_03145_171.28%10480.0MIA_03145_1
A0A0J9XDC5_GEOCN66.09%10440.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Geotrichum candidum GN=BN980_GECA11s02551g PE=3 SV=1
A0A060TIU1_BLAAD57.14%10640.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D41008g PE=3 SV=1
A0A1E3PIB7_9ASCO55.14%10500.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83223 PE=3 SV=1
A0A167E1N8_9ASCO55.14%10610.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Sugiyamaella lignohabitans GN=HMG1 PE=3 SV=1
Q6C704_YARLI52.88%10420.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E04807g PE=3 SV=1
UniRef50_Q6C70452.88%10420.03-hydroxy-3-methylglutaryl coenzyme A reductase n=7 Tax=Saccharomycetales TaxID=4892 RepID=Q6C704_YARLI
HMDH1_YEAST45.34%10740.03-hydroxy-3-methylglutaryl-coenzyme A reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HMG1 PE=1 SV=1
A0A1D8PD39_CANAL71.25%4730.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HMG1 PE=3 SV=1
A0A1E4TCF7_9ASCO71.14%4400.03-hydroxy-3-methylglutaryl coenzyme A reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32696 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8421

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 1000 1089

Detailed signature matches

  1. Family IPR002202
    Hydroxymethylglutaryl-CoA reductase, class I/II
    1. PF00368 (HMG-CoA_red)
    2. PS50065 (HMG_COA_RE...)
    3. PR00071 (HMGCOARDTASE)
  2. Family IPR004554
    Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
    1. TIGR00533
    2. cd00643 (HMG-CoA_re...)
  3. Domain IPR025583
    HMG-CoA reductase, N-terminal domain
    1. PF13323 (HPIH)
  4. Domain IPR000731
    Sterol-sensing domain
    1. PF12349 (Sterol-sen...)
    2. PS50156 (SSD)
  5. Domain IPR009029
    Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
    1. SSF56542 (Substrate...)
  6. Domain IPR023282
    Hydroxymethylglutaryl-CoA reductase, N-terminal
    1. G3DSA:1.10.32...
  7. Domain IPR009023
    Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
    1. G3DSA:3.30.70...
    2. SSF55035 (NAD-bindi...)
  8. Domain IPR023074
    Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
    1. G3DSA:3.90.77...
  9. SITE IPR023076
    Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
    1. PS00066 (HMG_COA_RE...)
    2. PS01192 (HMG_COA_RE...)
    3. PS00318 (HMG_COA_RE...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:1.20.16...
  3. NON_CYTOPLASM... (N...)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)
  6. mobidb-lite (disord...)

Residue annotation

  1. tetramerization in...
  2. inhibitor binding ...
  3. catalytic residues...
  4. substrate binding ...
  5. NADP(H) binding si...

Protein sequence

>MCA_01061_1
MSTINHQVANGSISKSYKFSKASSTASTKPSSKSSSSSSFESTPALLKPLLSFVIFLTLNAAKRPIHTIVSIAVLATTAH
LSILNLSVPNYIDSLSASYYHEGGDSWSNNSAEWIQVSDPETSYPSAVHFAGAKLVFAGYPNSQLPEIPFGIDTENQYEK
NLLIPYEKLNEWIESVSEITVKSLTADGKESEEVWRLRKSFSWIVWAKWNFSRLLDLIHDAETFDLIVILIGYLAMHYTF
ISLYLSMKRLGSKFWLATSVLLSSTFAFLLAYVTSFYLGVAVPIVTLSEGLPFLVATIGFGDKIRLTKGTLRALQSKSPG
TSIENVVSEVICQQGVTMLRNYAVECLALFGGAMFGVNGLWQFCFLGAITLIYDYFITATFYSAILSIKVEIGKIKQKEI
LRQALEEDGISSSVAESVATDSSEKTAMSKKTNFSITIFKVLMVSAFLMLNLVQLASPVPIFQSFKFFNSSASTATTSGS
LSENLIRLVPHSEQGAVVTILPAFIFEHASLSDRFDSVFHRFMRRWTETIGDPFISKFVVIGLVISIGLNAYLFNAARDP
VVVKVVEKIIEVEKKVPVYVSNSETPFSESGDSSENNSDTEGLELRIGSSYTRKTTEYTNESESGESNPEAKSLRSVDES
LVFMKAGKTKLLNNEEIVNLSLAGKLPLYALEKHLEDTTRAVAVRRAVVSRLSNTKKLEGSKLPFLHYDYDRVLGACCEN
VIGYVPLPIGVAGPLIIDGKEYFIPMATTEGCLVASTMRGCKAMNASGGVTTVLTHDGMTRGPCVQFPNLARAGEAKLWL
DSEEGQRTIKKAFNSTSRFARLQHIKTAMAGTLLFIRFCTTTGDAMGMNMISKGVEHSLKFMAEECGFEDMQEISVSGNY
CADKKPAAINWIEGRGKSVVAEAIVTKDVVERVLKSDVDALVELNISKNLVGSAMAGSIGGNNAQAANLVAAIFLATGQD
PAQVMESANCITLMKNVNGNLHISVSMPSIEVGTIGGGTILEPQGAMLDLLGVRGPHPTNPGDNARQLAKIVAGGVMAAE
LSLCSALAAGHLVQSHMALNRSKAPTPNPGASSANIQRLTEGSKICIKS

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0050662 coenzyme binding

Cellular Component

GO:0016021 integral component of membrane