Protein

MIA_03142_1

Length
315 amino acids

Browser: contig04:328867-329815-

Protein function

EGGNOG:0PJAQLIA1Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor (By similarity)
SGD closest match:S000003831LIA1Deoxyhypusine hydroxylase
CGD closest match:CAL0000183521LIA1Deoxyhypusine hydroxylase

Protein alignments

%idAln lengthE-value
MCA_01056_181.962%3160.0MCA_01056_1
A0A0J9XE94_GEOCN80.449%3120.0Deoxyhypusine hydroxylase OS=Geotrichum candidum GN=LIA1 PE=3 SV=1
A0A167EQG7_9ASCO74.038%3123.79e-168Deoxyhypusine hydroxylase OS=Sugiyamaella lignohabitans GN=LIA1 PE=3 SV=1
A0A060T668_BLAAD71.609%3173.61e-164Deoxyhypusine hydroxylase OS=Blastobotrys adeninivorans GN=LIA1 PE=3 SV=1
A0A1E3PRI6_9ASCO72.517%3021.13e-155Deoxyhypusine hydroxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=LIA1 PE=3 SV=1
DOHH_YARLI69.307%3037.10e-153Deoxyhypusine hydroxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LIA1 PE=3 SV=1
UniRef50_Q6CHJ769.307%3031.65e-149Deoxyhypusine hydroxylase n=5 Tax=Dikarya TaxID=451864 RepID=DOHH_YARLI
DOHH_CANAL66.340%3062.88e-143Deoxyhypusine hydroxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LIA1 PE=3 SV=1
A0A1E4THL6_9ASCO58.360%3172.17e-121Deoxyhypusine hydroxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=LIA1 PE=3 SV=1
DOHH_YEAST57.692%3124.76e-116Deoxyhypusine hydroxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LIA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0197

Protein family membership

Domains and repeats

  1. Domain
  2. Repeat
1 50 100 150 200 250 315

Detailed signature matches

  1. Family IPR027517
    Deoxyhypusine hydroxylase
    1. MF_03101 (Deoxyhypu...)
  2. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  3. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  4. Repeat IPR004155
    PBS lyase HEAT-like repeat
    1. SM00567 (EZ_HEAT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF13646 (HEAT_2)

Protein sequence

>MIA_03142_1
MDELRQVENQGESLDDLRTVLLNISGDVPLAHRFRALFNLKGLGHEGNNKAIDIIAEGFGDESELLKHELAYVLGQTKNL
YSATPLRSVLGDAQQPAMVRHEAAEALGALGDKDSLDILKQYMDDPLEVIRQTCELAIERIAWENSEAAKRENLEKSAFT
SIDPAPPLPSEISEISKLKELLNNQEESLFKRYRAMFRLRDIATTEAVLALASGFNDPSALFRHEIAYVFGQLCDPASVP
ALITVLSNEKEEGMVRHEAAEALGSIATDDVLPILNKFAKDNERVVRESALVALDMYEFENSDQIDYTVVPPVSN

GO term prediction

Biological Process

GO:0008612 peptidyl-lysine modification to peptidyl-hypusine

Molecular Function

GO:0005488 binding
GO:0019135 deoxyhypusine monooxygenase activity

Cellular Component

None predicted.