Protein

MCA_01056_1

Length
316 amino acids

Gene name: LIA1

Description: Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation

Browser: contigA:3366615-3367566-

RNA-seq: read pairs 830, FPKM 32.4, percentile rank 54.8% (100% = highest expression)

Protein function

Annotation:LIA1Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation
KEGG:K06072DOHH deoxyhypusine monooxygenase [EC:1.14.99.29]
EGGNOG:0PJAQLIA1Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor (By similarity)
SGD closest match:S000003831LIA1Deoxyhypusine hydroxylase
CGD closest match:CAL0000183521LIA1Deoxyhypusine hydroxylase

Protein alignments

%idAln lengthE-value
MIA_03142_181.96%3160.0MIA_03142_1
A0A0J9XE94_GEOCN79.55%3131e-180Deoxyhypusine hydroxylase OS=Geotrichum candidum GN=LIA1 PE=3 SV=1
A0A060T668_BLAAD72.01%3182e-163Deoxyhypusine hydroxylase OS=Blastobotrys adeninivorans GN=LIA1 PE=3 SV=1
A0A167EQG7_9ASCO72.20%3135e-161Deoxyhypusine hydroxylase OS=Sugiyamaella lignohabitans GN=LIA1 PE=3 SV=1
DOHH_YARLI70.39%3044e-153Deoxyhypusine hydroxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LIA1 PE=3 SV=1
UniRef50_Q6CHJ770.39%3041e-149Deoxyhypusine hydroxylase n=5 Tax=Dikarya TaxID=451864 RepID=DOHH_YARLI
A0A1E3PRI6_9ASCO68.65%3033e-144Deoxyhypusine hydroxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=LIA1 PE=3 SV=1
DOHH_CANAL66.99%3061e-141Deoxyhypusine hydroxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LIA1 PE=3 SV=1
A0A1E4THL6_9ASCO60.00%3151e-124Deoxyhypusine hydroxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=LIA1 PE=3 SV=1
DOHH_YEAST59.21%3042e-114Deoxyhypusine hydroxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LIA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0524

Protein family membership

Domains and repeats

  1. Domain
  2. Repeat
1 50 100 150 200 250 316

Detailed signature matches

  1. Family IPR027517
    Deoxyhypusine hydroxylase
    1. MF_03101 (Deoxyhypu...)
  2. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  3. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  4. Repeat IPR004155
    PBS lyase HEAT-like repeat
    1. SM00567 (EZ_HEAT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF13646 (HEAT_2)

Protein sequence

>MCA_01056_1
MDELRHVENQGEDLNSLRDILLNVSGNTPLAHRFRALFNLKNLGHEGNNRAIDIIAEGFKDESDLLKHELAYVLGQTKNL
YAIDALQAVLKDDKNQTPIVRHEAAEALGAIGDKRSLDILKTYLNDPLEVIRQTCELAIERIEWENSEAAKTEKIETSAF
TSIDPAPPLPSDISEIPKLQEILNDQSKSLFMRYRAMFRLRDIATKEAVLALATGFDDPSALFRHEIAYVFGQLCDPASV
PSLIKVLSNETEEGMVRHEAAEALGSIATDEVLPILNKFSQDEQRVVRESALVALDMYEFENSDQVDYTVVPPVTN

GO term prediction

Biological Process

GO:0008612 peptidyl-lysine modification to peptidyl-hypusine

Molecular Function

GO:0005488 binding
GO:0019135 deoxyhypusine monooxygenase activity

Cellular Component

None predicted.